CAS: 22446-37-3; Methyl 2-(2-Hydroxyphenyl)Acetate

该化合物是一种有机化合物,其特征为酯性功能组,产自盐酸和醋酸,其特点是附于一个苯环的氢氧基(-OH)组,具有芳香特性,该化合物一般是无色的,可粉色黄色液体,具有舒适,甜和薄荷芳香,通常与冬季绿色有关,在乙醇和乙醇等有机溶剂中溶解,但由于其疏水特性,水溶性有限. 甲基(2-羟基苯)乙酸盐用于各种用途,包括用作调味剂,香味成分和其他化学化合物的合成,此外,该混合物还展示了潜在的生物活动,包括抗炎和厌食性特性,引起药物研究的兴趣.安全数据表明,尽管一般认为低浓度为安全,但应当谨慎处理,以避免皮肤和眼刺激.

结构式图片

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

CAS号614-75-5 邻羟基苯乙酸 | CAS号67-56-1 甲醇 | CAS号553-86-6 苯并呋喃酮 | CAS号75-36-5 乙酰氯 | CAS号845786-35-8 methyl 2-(2-(2-... | CAS号70340-04-4 (2-羟基苄基)三苯基溴化磷 | CAS号79-22-1 氯甲酸甲酯 | CAS号7440-44-0 活性炭 | CAS号2065-23-8 苯氧乙酸甲酯 | CAS号93-25-4 2-甲氧基苯乙酸 | CAS号103-82-2 苯乙酸 | CAS号25563-02-4 2-苯氧基苯乙酸 | CAS号27798-60-3 2-甲氧基苯基乙酸甲酯 | CAS号34645-84-6 芬氯酸 | CAS号86308-89-6 3-[2-(2,4-Dichl... | CAS号40525-65-3 2-(2-(苄氧基)苯基)乙酸甲酯 | CAS号114077-60-0 (E)-methyl 2-[2...

合成工艺路线路线简述

    苯乙酸甲酯置于[rhcl2(P-Cymene)]2,[双(三氟乙酰氧基)碘]苯体系中,用 1,2-二氯乙烷 用作溶剂,化学反应 16.0H,以52%的收率获得2-羟基苯乙酸甲酯
    参考文献:弱配位对钌(ii / Iv)催化的远端ch加氧的见解.
    标题:弱配位对钌(ii / Iv)催化的远端ch加氧的见解.
    摘要:芳基乙酰胺和烷基苯基乙酰基酯的ch羟基化反应通过使用通用钌(ii / Iv)催化挑战远端弱o-配位而实现的.钌(II)催化的芳基乙酰胺的ch氧化通过ch活化,钌(ii / Iv)的氧化和还原性消除进行,从而提供了经济地获取有价值的酚的方法.所述p-Cymene-钌(ii / Iv)歧管,通过详细的实验和dft计算性研究确定.
    Doi:10.1002/chem.202003062

    海关参考信息

    专利信息


    专利号:US-6812320-B2
    优先权日:2002-03-25
    标题:Method for copolyestercarbonate synthesis
    发明人:SILVA JAMES MANIO; DARDARIS DAVID MICHEL; O'NEIL GREGORY ALLEN; SYBERT PAUL DEAN; SU ZHAOHUI
    权利人:GEN ELECTRIC
    摘要:Thermally stable block copolyestercarbonates comprising chain members derived from at least one dihydroxy-substituted aromatic hydrocarbon moiety and at least one aromatic dicarboxylic acid moiety, said polymer being substantially free of anhydride linkages linking at least two mers of the polyester chain segments, are prepared by a method comprising the steps of: (a) preparing a hydroxy-terminated polyester intermediate comprising structural units derived from at least one dihydroxy-substituted aromatic hydrocarbon moiety and at least one aromatic dicarboxylic acid moiety; and (b) conducting a reaction of the polyester intermediate with phosgene in a reaction mixture comprising water, a substantially water-immiscible organic solvent, and a base, wherein base and phosgene are added simultaneously to the reaction mixture at a substantially constant molar ratio of base to phosgene for a time period of at least about 60% of the total amount of phosgene added.

    专利号:RU-2024511-C1
    优先权日:1986-04-17
    标 题 :Method of synthesis of e-isomers of acrylic acid derivatives

    专利号:JP-2005521765-A
    优先权日:2002-03-25
    标题 :Synthesis of copolyestercarbonate

    专利号:ES-2290440-T3
    优先权日:2002-03-25
    标题 :METHOD FOR SYNTHESIS OF COPOLIESTERCARBONATES.

    专利号:US-6090805-A
    优先权日:1997-06-18
    标 题 :Tocolytic oxytocin receptor antagonists
    发明人:WILLIAMS PETER D; SPARKS MICHELLE A; BELL IAN; PERLOW DEBRA S; STAUFFER KENNETH; FREIDINGER ROGER M
    权利人:MERCK & CO INC
    摘要:This invention relates to certain novel benzoxazinone compounds and derivatives thereof, their synthesis, and their use as oxytocin receptor antagonists. One application of these compounds is in the treatment of preterm labor in mammals, especially humans. The ability of the compounds to relax uterine contractions in mammals also makes them useful for treating dysmenorrhea and stopping labor prior to cesarean delivery.

    专利号:US-5968938-A
    优先权日:1997-06-18
    标 题 :Piperazine oxytocin receptor antagonists
    发明人:WILLIAMS PETER D; SPARKS MICHELLE A; BELL IAN; GUARE JR JAMES P; FREIDINGER ROGER M
    权利人:MERCK & CO INC
    摘要:This invention relates to certain novel piperazine compounds and derivatives thereof, their synthesis, and their use as oxytocin receptor antagonists. One application of these compounds is in the treatment of preterm labor in mammals, especially humans. The ability of the compounds to relax uterine contractions in mammals also makes them useful for treating dysmenorrhea and stopping labor prior to cesarean delivery.
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    合成参考文献


    参考文献:10.1016/j.ejmech.2008.04.019
    摘要:Lv P, Xiao Z, Fang R, Li H, Zhu H, Liu C. Synthesis, characterization and structure–activity relationship analysis of novel depsides as potential antibacterials. European Journal of Medicinal Chemistry. 2009 Apr;44(4):1779–87. doi: 10.1016/j.ejmech.2008.04.019.
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