合成目标产物 Methyl Isonicotinate 主要起始原料 Isonicotinic Acid And Methanol
(文献来源)合成步骤主要原料 Isonicotinic Acid 和 Methanol
异烟酸置于氯化亚砜体系中,化学反应 0.34H,反应生成异烟酸甲酯 参考文献: Process For The Preparation Of 3-(4-Pyridinyl)-Propanol And Intermediates Useful In Its Synthesis[fr] Procédé De Préparation De 3-(4-Pyridinyl)-Propanol Et Intermédiaires Utilisés Dans Sa Synthèse 标题: Process For The Preparation Of 3-(4-Pyridinyl)-Propanol And Intermediates Useful In Its Synthesis[fr] Procédé De Préparation De 3-(4-Pyridinyl)-Propanol Et Intermédiaires Utilisés Dans Sa Synthèse 摘要:一种制备3-(4-吡啶基)-丙醇或其盐以及在其合成中有用的中间体的方法.
专利号:US-5702928-A 优先权日:1994-07-18 标题 :Process for producing optically active triazole compounds and method of racemizing optically active triazole compounds 发明人:KAWADA NAOKI; YAMAZAKI NORITSUGU; IMOTO TAKAFUMI; IKURA KIYOSHI 权利人:DAICEL CHEM 摘要:PCT No. PCT/JP95/01416 Sec. 371 Date May 24, 1996 Sec. 102(e) Date May 24, 1996 PCT Filed Jul. 17, 1995 PCT Pub. No. WO96/02664 PCT Pub. Date Feb. 1, 1996A process for the asymmetric synthesis of a compound represented by general formula (II-R) easily at a low cost by using a lipase, and a process for producing a compound to be utilized in the above synthesis. (II-R)
专利号:US-4965397-A 优先权日:1989-01-23 标题:Novel dibasic acid salts and their synthesis 发明人:SCHACHT ETIENNE; CROMMEN JAN 权利人:ETHYL CORP 摘要:The protecting group, Z, of protected alpha-amino acid esters of the formula n n Z--NH--CH(R.sub.2)COOCH(R)COOR.sub.1 n n is removed in the presence of a dibasic acid such as oxalic acid. This results in the formation of a new type of salt of an amino acid ester which may be represented by the formula ##STR1## In the above Q is a divalent hydrocarbyl residue of a dibasic acid, R is a hydrogen atom or hydrocarbyl group, R 1 is a hydrocarbyl group, R 2 is a hydrogen atom or hydrocarbyl group, and p is zero or one, preferably zero. When p is zero, the salts are oxalate salts. When p is one, the salts are salts of other dibasic acids. The salts (II) are useful as reactants in the synthesis of amino-acid substituted phosphazene polymers.
专利号:US-8877935-B2 优先权日:2010-06-08 标 题:One-pot process for the synthesis of dalfampridine 发明人:GARAVAGLIA FABIO; BAROZZA ALESSANDRO; ROLETTO JACOPO; PAISSONI PAOLO 权利人:GARAVAGLIA FABIO; BAROZZA ALESSANDRO; ROLETTO JACOPO; PAISSONI PAOLO; PROCOS SPA 摘要:A process for the preparation of Dalfampridine (1), 4-aminopyridine, starting from 4-pyridinecarbonitrile using a one-pot procedure. n n n n n n n n n n Said process is carried out with no need for isolating intermediates and is particularly advantageous as far as environment, yields, productivity and purity of the resulting product are concerned, both in the reaction mixture and in the isolated crystal.
专利号:US-7309799-B2 优先权日:2004-06-01 标 题:Methods for the synthesis of milnacipran and congeners thereof 发明人:BUCHWALD STEPHEN L; SWAGER TIMOTHY M; RARIY ROMAN V 权利人:COLLEGIUM PHARMACEUTICAL INC 摘要:One aspect of the present invention relates to methods for synthesizing milnacipran or congeners thereof. Another aspect of the present invention relates to asymmetric methods for synthesizing enantiomerically enriched milnacipran or congeners thereof. The present invention also relates to methods for synthesizing intermediates useful in the non-asymmetric or asymmetric methods for synthesizing enantiomerically enriched milnacipran or congeners thereof.
专利号:US-2003072716-A1 优先权日:2001-06-22 标 题:Renewable, carbohydrate based CO2-philes 发明人:POOVATHINTHODIYIL RAVEENDRAN; WALLEN SCOTT L 摘要:A composition is disclosed comprising a carbohydrate-based material a dispersed in carbon dioxide. A general method for synthesizing inexpensive, renewable, non-toxic, non-fluorous, carbohydrate based CO 2 -philes is disclosed. These CO 2 -philes are soluble in carbon dioxide. Methods of making the composition are also disclosed. The methods and composition are useful in a variety of applications and can utilize gaseous, liquid and supercritical carbon dioxide. The methods and compositions are useful in the synthesis of surfactants and metal chelates for CO 2 , as a sizing substrate, in CO 2 -based coating processes, for impregnation and plasticizing cellulosic and non-cellulosic materials, in pharmaceutical applications, such as crystallization, dispersion and encapsulation of bioactive molecules in solid systems, in the densification of CO 2 , in the synthesis of biodegradable polymers in CO 2 , and for carbon dioxide removal, to name just a few.
专利号:WO-2011138250-A1 优先权日:2010-05-03 标题 :Process for the preparation of 3-(4-pyridinyl)-propanol and intermediates useful in its synthesis 发明人:ATTOLINO EMANUELE; DE MARCO ALESSANDRO; ALLEGRINI PIETRO 权利人:DIPHARMA FRANCIS SRL; ATTOLINO EMANUELE; DE MARCO ALESSANDRO; ALLEGRINI PIETRO 摘要:A process for the preparation of 3-(4-pyridinyl)-propanol or a salt thereof and intermediates useful in its synthesis.
摘要:Kwiecień, H., Science of Synthesis Knowledge Updates, (2014) 4, 165. 摘要:Spitzner, D., Science of Synthesis Knowledge Updates, (2016) 1, 161. 摘要:Mourad, A. K.; Czekelius, C., Science of Synthesis Knowledge Updates, (2011) 3, 88. 摘要:Atodiresei, I.; Rueping, M., Science of Synthesis Knowledge Updates, (2017) 1, 392. 摘要:R. W. Green and H. K. Tong. J. Am. Chem. Soc. 78, 4896 (1956).