CAS: 2757-23-5; S-Chloro Chloromethanethioate

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CAS号594-42-3 全氯甲硫醇 | CAS号87463-08-9 dichloromethoxy... | CAS号87463-09-0 2,2-dichloroeth... | CAS号85963-74-2 2,2,4,4-tetrach... | CAS号4524-93-0 环戊基甲酰氯 | CAS号42252-34-6 N-乙基甲基氨基甲酰氯 | CAS号502-55-6 二黄原酸 | CAS号100244-68-6 [ethoxy(thi°Car... | CAS号105-58-8 碳酸二乙酯 | CAS号407-25-0 三氟乙酸酐(TFAH) | CAS号21597-13-7 4-benzyl-1,2,4-... | CAS号463-58-1 羰基硫 | CAS号110991-37-2 3-p-nitrophenyl...

三氯硫氯甲烷置于硫酸,水体系中,用65%的收率获得氯羰基亚磺酰氯
参考文献:氯羰基亚磺酰氯制备 1,1-二甲基-3-芳基脲的改进方法
标题:氯羰基亚磺酰氯制备 1,1-二甲基-3-芳基脲的改进方法
摘要:摘要 报道了一种制备具有除草特性的芳基脲的简便方法.该方法分为两个步骤:(1) 芳胺与氯代羰基亚磺酰氯在非极性溶剂存在下反应生成芳基羰基亚磺酰氯;(2) 与二甲胺在相转移催化剂的催化下进行两相反应生成相应的芳基羰基亚磺酰氯.尿素.图形概要
Doi:10.1080/00397911.2010.530374

专利信息

专利号:US-12162849-B2
优先权日:2018-12-21
标题 :Synthesis of 3-methyl-1,2,4-thiadiazole-5-carbohydrazide or of the methyl-d3 deuterated form thereof
发明人：HOVEYDA HAMID; DUTHEUIL GUILLAUME
权利人:OGEDA SA
摘要:The present invention relates to a method of synthesis of compound (I), wherein R1 represents methyl or methyl-d3, thus corresponding to 3-methyl-1,2,4-thiadiazole-5-carbohydrazide or to the methyl-d3 deuterated form thereof. These compounds are useful as key intermediates in the synthesis of pharmaceutical compounds, especially fezolinetant and deuterated fezolinetant.

专利号:US-9475814-B2
优先权日:2011-10-03
标题:Chiral N-acyl-5,6,7(8-substituted)-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazines as selective NK-3 receptor antagonists, pharmaceutical composition, methods for use in NK-3 receptor mediated disorders and chiral synthesis thereof
发明人：HOVEYDA HAMID R; DUTHEUIL GUILLAUME; FRASER GRAEME L; ROY MARIE-ODILE; EL BOUSMAQUI MOHAMED; BATT FREDERIC
权利人:EUROSCREEN SA
摘要:The present invention relates to novel compounds of Formula I and their use in therapeutic treatments. The invention further relates to a novel chiral synthesis of 5,6,7,(8-substituted)-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazines using N-sp3 protective groups. The invention also provides intermediates for use in the synthesis of compounds of Formula I.

专利号:US-2014303363-A1
优先权日:2011-12-09
标题 :Preparation and Use of Isolactosamine and Intermediates therefor
发明人：HEDEROS MARKUS; RISINGER CHRISTIAN; BOUTET JULIEN; DEKANY GYULA
权利人:GLYCOM AS
摘要:The invention relates to providing isolactosamine (Galβ1-3GlcNH 2 , formula 1) and salts thereof in the form of either anomer or mixture thereof, as well as hydrates or solvates of the free base and salts thereof. The synthesis of isolactosamine and its use in the synthesis of lacto-N-biose containing oligosaccharides are also disclosed.

专利号:US-8431693-B2
优先权日:2004-04-05
标题:Process for desilylation of oligonucleotides
发明人：MANOHARAN MUTHIAH; JUNG MICHAEL F; RAJEEV KALLANTHOTTATHIL G; PANDEY RAJENDRA K; WANG GANG
权利人:MANOHARAN MUTHIAH; JUNG MICHAEL F; RAJEEV KALLANTHOTTATHIL G; PANDEY RAJENDRA K; WANG GANG; ALNYLAM PHARMACEUTICALS INC
摘要:The present invention relates to processes and reagents for oligonucleotide synthesis and purification. One aspect of the present invention relates to compounds useful for activating phosphoramidites in oligonucleotide synthesis. Another aspect of the present invention relates to a method of preparing oligonucleotides via the phosphoramidite method using an activator of the invention. Another aspect of the present invention relates to sulfur-transfer agents. In a preferred embodiment, the sulfur-transfer agent is a 3-amino-1,2,4-dithiazolidine-5-one. Another aspect of the present invention relates to a method of preparing a phosphorothioate by treating a phosphite with a sulfur-transfer reagent of the invention. In a preferred embodiment, the sulfur-transfer agent is a 3-amino-1,2,4-dithiazolidine-5-one. Another aspect of the present invention relates to compounds that scavenge acrylonitrile produced during the deprotection of phosphate groups bearing ethylnitrile protecting groups. In a preferred embodiment, the acrylonitrile scavenger is a polymer-bound thiol. Another aspect of the present invention relates to agents used to oxidize a phosphite to a phosphate. In a preferred embodiment, the oxidizing agent is sodium chlorite, chloroamine, or pyridine-N-oxide. Another aspect of the present invention relates to methods of purifying an oligonucleotide by annealing a first single-stranded oligonucleotide and second single-stranded oligonucleotide to form a double-stranded oligonucleotide; and subjecting the double-stranded oligonucleotide to chromatographic purification. In a preferred embodiment, the chromatographic purification is high-performance liquid chromatography.

专利号:US-6500944-B2
优先权日:1997-07-16
标题:Sulfurizing reagent: 3-aryl-1,2,4-dithiazoline-5-ones
发明人：ROY SAROJ K; TANG JIN-YAN
权利人:AVECIA BIOTECHNOLOGY INC
摘要:The invention relates to the chemical synthesis of oligonucleotides and to chemical entities useful in such synthesis. More particularly, the invention relates to sulfurization of the internucleotide linkages of oligonucleotides. The invention provides a process to synthesize new sulfur transfer reagents and a process for their use in sulfurizing oligonucleotides. The sulfur transfer reagents according to the invention are inexpensive to make, stable in storage and in solution, and highly efficient in sulfurization.

专利号:WO-2020128003-A1
优先权日:2018-12-21
标 题 :SYNTHESIS OF 3-METHYL-1,2,4-THIADIAZOLE-5-CARBOHYDRAZIDE OR OF THE METHYL-d3 DEUTERATED FORM THEREOF