CAS: 51105-90-9; Methyl 1H-Pyrazole-4-Carboxylate

相似化合物

181997-36-4 37718-11-9 1197230-88-8

上下游产品

CAS号37718-11-9 1H-吡唑-4-甲酸 | CAS号875554-08-8 methyl 1-trityl... | CAS号80981-24-4 N-ethyl-N-(meth... | CAS号80981-26-6 N-(ethylcarbamo... | CAS号124-41-4 甲醇钠 | CAS号80981-23-3 4-ureid°Carbony... | CAS号186581-53-3 重氮甲烷 | CAS号922-67-8 甲基丙烯酸酯 | CAS号29097-00-5 3-氨基吡唑-4-甲酸甲酯 | CAS号4634-13-3 6-苯基烟酸甲酯 | CAS号64074-29-9 甲基 2-苯基嘧啶-5-羧酸酯 | CAS号5571-03-9 2-甲基嘧啶-5-羧酸甲酯

1H-吡唑-4-甲酸置于盐酸体系中,用 甲醇,水 作为反应溶剂,以79.6%的收率获得产物吡唑-4-羧酸甲酯
参考文献:Metallacarborane Chelates
标题:Metallacarborane Chelates
摘要:金属卡巴烷螯合抗体化合物可用于放射免疫检测和放射疗法.这些化合物的化学式为##str1##其中x是金属或该金属的放射性同位素,Y是具有旋转抗性的有机螯合桥基团,Z是抗体连接基团,Ab是抗体.还公开了金属卡巴烷螯合和卡巴烷螯合化合物,这些化合物可用于制备最终用于放射免疫检测和放射疗法的金属卡巴烷螯合-抗体化合物.

专利信息

专利号:US-2024239799-A1
优先权日:2021-04-02
标 题:(s)-1-(5-((pyridin-3-yl)thio)pyrazin-2-yl)-4'h,6'h-spiro[piperidine-4,5'-pyrrolo [1,2-b]pyrazol]-4'-amine derivatives and similar compounds as shp2 inhibitors for the treatment of e.g. cancer
发明人：DI FABIO ROMANO; MONTALBETTI CHRISTIAN; PETROCCHI ALESSIA; GRILLO ALESSANDRO; RANDAZZO PIETRO; ROSSETTI ILARIA; CIAMMAICHELLA ALINA
权利人:C N C C S S C A R L COLLEZIONE NAZ DEI COMPOSTI CHIMICI E CENTRO SCREENING; IRBM S P A
摘要:The present invention relates to compounds of formula (I). The compounds of the formula (I) are e.g. (S)-1-(5-((pyridin-3-yl)thio) pyrazin-2-yl)-41H,6′H-spiro[piperidine-4,5′-pyrrolo[1,2-b]pyrazol]-41-amine derivatives and similar compounds. The present invention also relates to the compounds of formula (I) for use as Src homology phosphotyrosine phosphatase 2 (SHP2) inhibitors in methods of treatment of e.g. cancer, cardiovascular diseases, immunological disorders, autoimmune disorders, fibrosis, ocular disorders, systemic lupus erythematosus, diabetes, neutropenia, and combinations thereof. The present invention also relates to pharmaceutical compositions containing said compounds and to their methods of synthesis.

专利号:US-2008200475-A1
优先权日:2005-03-28
标题:4-Piperazinothieno[2,3-D] Pyrimidine Compounds As Platelet Aggregation Inhibitors
发明人：ENNIS MICHAEL DALTON; KORTUM STEVEN WADE; TENBRINK RUTH ELIZABETH
权利人:PFIZER
摘要:Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I: (I) wherein A 1 , A 2 , A 3 , A 4 , A 5 , A 6 , A 7 , A 8 , X 4 , X 6 , R 2a , R x , R 4 , R 5 , and R 6 are as defined in the detailed description of the invention. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

专利号:US-9744173-B2
优先权日:2014-04-10
标题 :2-amino 6-methyl-4,4a,5,6-tetrahydropyrano[3,4-d][1,3]thiazin-8a(8H)-yl-1,3-thiazol-4-yl amides
发明人：BRODNEY MICHAEL AARON; BECK ELIZABETH MARY; BUTLER CHRISTOPHER RYAN; ZHANG LEI; O'NEILL BRIAN THOMAS; BARREIRO GABRIELA; LACHAPELLE ERIK ALPHIE; ROGERS BRUCE NELSEN
权利人:PFIZER
摘要:The present invention is directed to compounds, tautomers and pharmaceutically acceptable salts of the compounds which are disclosed, wherein the compounds have the structure of Formula I, n nand the variable R 1 is as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

专利号:KR-20130061129-A
优先权日:2010-03-29
标 题 :Synthesis method of pyrazole through coupling of carboxylic acid derivative and enamine