CAS: 69304-37-6; 1,3-Dichloro-1,1,3,3-Tetraisopropyldisiloxane

上下游产品

CAS号18043-71-5 1,1,3,3-四异丙基二硅氧烷 | CAS号18173-84-7 hydroxy-di(prop... | CAS号18043-71-5 1,1,3,3-四异丙基二硅氧烷 | CAS号69304-42-3 (+)-3',5'-O-(1,... | CAS号148437-94-9 O6-苄基-N2,3-乙烯桥-... | CAS号148437-93-8 O6-Benzyl-N2,3-... | CAS号80545-44-4 2,4(1H,3H)-Pyri...

1,1,3,3-Tetraisopropyldisiloxane置于氯体系中,用 二氯甲烷 作为反应溶剂,以61 G的收率获得产物1,3二氯-1,1,3,3-四异丙基二硅氧烷
参考文献:手性羟甲基:2'-脱氧核糖核苷的前手性c-5'质子的1H NMR归属
标题:手性羟甲基:2'-脱氧核糖核苷的前手性c-5'质子的1H NMR归属
摘要:2'-脱氧腺苷,2'-脱氧胞苷,2'-脱氧鸟苷和2'-脱氧尿苷在c-5'处通过立体选择性氘化制备,并用于在2H2O中获得的300 Mhz 1H NMR光谱中分配前手性c-5'质子.在所有情况下,发现更多屏蔽的 C-5' 质子是 Pro-R 质子.从这些分配中,C-4'-c-5' 旋转异构体群体使用三种先前发表的基于自旋耦合的方法确定,3J(H-4',H-5'R) 和 3J(H-4',H ‐5'S),并评估了与这些方法相关的错误.讨论了碱基结构,呋喃糖和 N-糖苷键构象对核苷中羟甲基旋转异构体相对种群的影响.
DOI:10.1002/mrc.1260280409

专利信息

专利号:US-6639059-B1
优先权日:1999-03-24
标 题 :Synthesis of [2.2.1]bicyclo nucleosides
发明人：KOCHKINE ALEXEI; FENSHOLDT JEF; PFUNDHELLER HENRIK M
权利人:EXIQON AS
摘要:A synthesis of [2.2.1]bicyclo nucleosides which is shorter and provides higher overall yields proceeds via the key intermediate of the general formula III, wherein R4 and R5 are, for instance, sulfonates and R7 is, for instance, a halogen or an acetate. From compounds of the general formula II, such as 3-O-aryl-4-C-hydroxymethyl-1,2-O-isopropylidene-alpha-D-ribofuranose, intermediates of the general formula III are suitable for coupling with silylated nucleobases. Upon one-pot base-induced ring-closure and desulfonation of the formed [2.2.1]bicyclo nucleoside, a short route to each the LNA (Locked Nucleic Acid) derivatives of adenosine, cytosine, uridine, thymidine and guanidine is demonstrated. The use of the 5'-sulfonated ring-closed intermediate also allows for synthesis of 5'-amino- and thio-LNAs.

专利号:US-9334273-B1
优先权日:2014-03-05
标题:Efficient and stereoselective synthesis of 2′-fluoro-6′-methylene-carbocyclic adenosine (FMCA)
发明人：CHU DAVID C K; SINGH UMA S
权利人:UNIV GEORGIA
摘要:The invention provides a new convergent approach for the synthesis of 2′-fluoro-6′-methylene-carbocyclic adenosine (FMCA) from a readily available starting material (Vince lactam) in fourteen steps. An efficient and practical methodology for stereospecific preparation of a versatile carbocyclic key intermediate, D -2′-fluoro-6′-methylene cyclopentanol by diazotization, elimination, stereoselective epoxidation, fluorination and oxidative reduction of the Vince lactam in twelve steps is also provided.

专利号:EP-0948511-B1
优先权日:1996-12-24
标 题:Chemical synthesis of nucleosides analogs and their incorporation into polynucleotides
发明人：KARPEISKY ALEXANDER; BEIGELMAN LEONID; MATULIC-ADAMIC JASENKA
权利人:SIRNA THERAPEUTICS INC
摘要:Novel nucleosides, process for chemical synthesis of nucleosides and incorporation of the nucleosides into polynucleotides are disclosed. Also described are polynucleotides, such as antisense, TFO and nucleic acid catalysts with one or more modifications, such as 2'-O-amino, L-nucleotides and the others.

专利号:US-5324831-A
优先权日:1988-04-06
标题:Phosphoramidite reagent for chemical synthesis of modified DNA
发明人：MARQUEZ VICTOR E; GODDARD AMANDA J
权利人:US HEALTH
摘要:5,6-dihydro-5-azacytidine phosphoramidite is useful in the synthesis of oligonucleotides and DNA containing dihydro-5-aza- and 5-azacytosine bases. The modified oligonucleotides which contain 5-azacytosine residues at specific sites can be used to determine the mechanism of selective gene activation and the relationship existing between the presence of the triazine base and inhibition of DNA methylation.

专利号:US-6972330-B2
优先权日:1996-02-13
标题:Chemical synthesis of methoxy nucleosides
发明人：BEIGELMAN LEONID; HAEBERLI PETER; KARPEISKY ALEXANDER; SWEEDLER DAVID
权利人:SIRNA THERAPEUTICS INC
摘要:Process for chemical synthesis of methoxy nucleosides.

专利号:US-7342003-B2
优先权日:2001-10-25
标 题 :Synthesis of 2-aralkyloxyadenosines, 2-alkoxyadenosines, and their analogs
发明人：MOORMAN ALLAN R; SCANNELL MICHAEL; BALASUBRAMANIAN THIAGARAJAN; OUTCALT RUSSELL; LEUNG EDWARD
权利人:KING PHARMACEUTICALS RES & DEV
摘要:Provided is a method for the synthesis of an aralkyloxyadenosine or an alkoxyadenosine. The method includes protecting the hydroxyl sugar groups with a protecting group to produce a protected halogenated adenosine. The protected halogenated adenosine is alkoxylated, and the hydroxyl sugar groups of the protected halogenated adenosine are deprotected to provide the aralkyloxyadenosine or alkoxyadenosine.