CAS: 70982-53-5; L-Vinylglycine

相似化合物

75266-38-5 105763-41-5 1025434-04-1

上下游产品

CAS号75-11-6 二碘甲烷 | CAS号183671-34-3 Lajoie's serine... | CAS号1779-49-3 甲基三苯基溴化膦 | CAS号91028-39-6 (S)-2-((叔丁氧羰基)氨... | CAS号75266-39-6 (S)-2-[(benzylo... | CAS号335170-39-3 benzyl ((1S,2S)... | CAS号91028-44-3 3-Butenoic acid... | CAS号67-21-0 DL-乙硫氨酸 | CAS号59-51-8 DL-蛋氨酸 | CAS号600-18-0 2-丁酮酸 | CAS号1492-24-6 L-2-氨基丁酸

N-Acetyl-2-Aminobut-3-Enoic Acid 反应 2.0H,反应生成 L-乙烯基甘氨酸
参考文献:Syntheses Of Optically Active,Protected And Unprotected Vinylglycines.
标题:Syntheses Of Optically Active,Protected And Unprotected Vinylglycines.
摘要:乙烯基甘氨酸(2)在酸性条件下会发生消旋化.通过酶水解 N-乙酰乙烯基甘氨酸 (5),然后重结晶,从 2-Hcl 中得到了光学纯度为 2 的乙烯基甘氨酸.(在酸性条件下,(S)-N-(甲氧羰基)乙烯基甘氨酸(6)的构型非常不稳定,因此无法从 2 中得到光学纯的 6.另一方面,从(S)-高丝氨酸合成了构型稳定的(S)-N-(9-苯基芴-9-基)乙烯基甘氨酸甲酯(9).
DOI:10.1248/cpb.42.1927

专利信息

专利号:WO-9726002-A1
优先权日:1996-01-17
标 题:Synthesis of conformationally restricted amino acids, peptides and peptidomimetics by catalytic ring closing metathesis
发明人：GRUBBS ROBERT H; MILLER J SCOTT; BLACKWELL HELEN E
权利人:CALIFORNIA INST OF TECHN
摘要:A method for synthesizing conformationally restricted amino acids, peptides, and peptidomimetics by ring closing metathesis. The method includes the steps of synthesizing a peptide precursor containing first and second unsaturated C-C bonds and contacting the peptide precursor with an RCM catalyst to yield a conformationally restricted peptide. Suitable peptide precursors may contain two or more unsaturated C-C bonds. These bonds may be olefinic bonds and may be contained in first and second alkenyl groups which may be allyl groups. The RCM catalyst may be a Ruthenium or Osmium carbene complex catalyst and more specifically, a Ruthenium or Osmium carbene complex catalyst that includes a Ruthenium or Osmium metal center that is in a +2 oxidation state, has an electron count of 16, and is pentacoordinated. The method may be carried out using solid-phase-peptide-synthesis techniques. In this embodiment, the precursor, which is anchored to a solid support, is contacted with an RCM catalyst and the product is then cleaved from the solid support to yield a conformationally restricted peptide.

专利号:US-2024209029-A1
优先权日:2021-04-21
标题:Adiponectin glycopeptides and compositions and methods of use thereof
发明人：WANG YU; LI XUECHEN; XU AIMIN; WU HONGXIANG; ZHANG YIWEI; LI YUANXIN
权利人:UNIV HONG KONG
摘要:An improved method for the chemical synthesis of glycosylated peptides has been developed. The method uses stereoselective glycan synthesis and chemical peptide ligation to produce glycopeptides at lower-cost and with higher efficiency/yield compared to conventional methods. In particular, a method for the large-scale, chemical synthesis of hydroxylated amino acid building blocks and glycosylated amino acids suitable for solid phase peptide synthesis (SPPS) are disclosed. SPPS-based methods using the glycosylated amino acids to chemically synthesize adiponectin-like peptides are also described. In vivo studies show that the adiponectin mimicking glycopeptides exhibit significant anticancer, anti-obesity and insulin sensitizing effects. Pharmaceutical compositions of the synthetic glycopeptides and methods of use thereof in treating diseases associated with deficient adiponectin are also described.

专利号:WO-2008098280-A1
优先权日:2007-02-16
标题:Methods for the synthesis of dicarba bridges in growth hormone peptides
发明人：ROBINSON ANDREA JANE; VAN LIEROP BIANCA; WHELAN AMANDA
权利人:POLYCHIP PHARMACEUTICALS PTY; UNIV MONASH; ROBINSON ANDREA JANE; VAN LIEROP BIANCA; WHELAN AMANDA
摘要:The invention relates to peptides comprising the carboxy terminal sequence of a growth hormone or an analogue of such a peptide in which the disulfide bridge is replaced by a dicarba bridge. Compositions containing such dicarba bridged peptides and method of treating obesity in an animal such as a human comprising administration of such dicarba bridged peptides are also disclosed.

专利号:US-6069272-A
优先权日:1992-03-09
标 题:Simplified method for the production of vinyl glycine (2-aminobut-3-enoic acid) and a convenient resolution of a derivative
发明人：CROUT DAVID HERBERT GEORGE; HALLINAN KEITH OLIVER
权利人:HOECHST AG
摘要:The invention relates to a three-step synthesis of vinyl glycine (1) using a cheap, commercially available starting material (3-butenenitrile (2)) and using cheap, simple reagents. Also disclosed is a convenient optical resolution of the N-tert.butyloxycarbonyl derivative by papain-catalyzed enantioselective esterification in a two-phase system.

专利号:US-8580998-B2
优先权日:2008-12-11
标题 :Preparation of alkenes by mild thermolysis of sulfoxides
发明人：LONG TIMOTHY EDWARD; PATEL SRAVAN KUMAR
权利人:LONG TIMOTHY EDWARD; PATEL SRAVAN KUMAR; UNIV GEORGIA
摘要:Embodiments of this disclosure, among others, encompass methods for generating alkenes under mild thermolytic conditions that can provide almost total conversion of a precursor compound to an alkene without isomerization or the need to chromatographically purify the final product By selectively blocking the amino and carboxy groups of the derivatized amino acid, the methods of the disclosure provide for the synthesis of a peptide having the vinylglycine moiety at either the carboxy or the amino terminus of the peptide The mild conditions for the thermolytic removal of an o-NO 2 -phenyl substituted aryl group ensure that there is minimal if any damage to thermally sensitive conjugates such as a peptide bearing the vinylglycine The methods of the present disclosure have practical applications for the preparation of unsaturated compounds under mild, thermolytic conditions.

专利号:US-7393954-B2
优先权日:2002-12-12
标题:Process for the production of pentostatin aglycone and pentostatin
发明人：NADJI SOURENA; SMOOT JAMES; SAMPATH UMASHANKER
权利人:RELIABLE BIOPHARMACEUTICAL COR
摘要:A novel, scaleable and improved process for preparing pentostatin and its analogs is disclosed. The method comprises the diastereospecific synthesis of the nucleobase from commercially available L-Dialkyl tartarates.