CAS: 7517-19-3; H-Leu-Ome.Hcl

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L-亮氨酸置于氯化亚砜体系中,化学反应生成 L-亮氨酸甲酯盐酸盐
参考文献:用非编码α-氨基异丁酸的模型肽进行β-转角开放的研究
标题:用非编码α-氨基异丁酸的模型肽进行β-转角开放的研究
摘要:单晶x射线衍射研究表明,在三个末端受保护的模型三肽i-Iii中,Boc-Ile-Aib-Xx-Ome(肽i中的xx :Val;ii:Leu;iii:Phe)具有非中心位置编码的氨基酸aib(aib:α-氨基异丁酸),肽段i对β-Turn显示构象偏好,肽段ii形成水合的β-Turn,代表溶剂介导的中间体,用于β-Turn和β-Strand之间的相互转化和肽iii采用完全展开的β链状结构.通过改变第三残基的空间体积xx(3),已分离出与β-转角和β-链之间的结构互变有关的各种构象.溶液相中的肽构象已通过溶剂依赖性NMR滴定和cd光谱法进行了探测.扫描电子显微镜(sem)的形态学研究表明,在三种肽中,只有肽iii可以形成固态的丝状原纤维.
DOI:10.1016/j.Tet.2007.07.075

专利信息

专利号:WO-2023030277-A1
优先权日:2021-08-30
标 题:Method for fully liquid-phase synthesis of grnh nonapeptide amide analog
发明人：SUN PENGCHENG; PAN JING; WU JUNYONG; TANG YONGBO; Du Yixiong; GUO LIN
权利人:HUNAN MICRO PEPTIDE BIOMEDICAL CO LTD
摘要:Provided is a method for fully liquid-phase synthesis of a GRnH nonapeptide amide analog, which belongs to the technical field of medicine synthesis. The method comprises respectively synthesizing a 'Trp-Ser-Tyr' fragment, an 'R-Leu' fragment, a 'Pyr-His' fragment and 'Arg-Pro-Hunan T', wherein, R = D-Ala (alarelin), D-Leu (leuprorelin), D-Trp (deslorelin) and D-His (histrelin), and obtaining the GRnH nonapeptide amide analog with high yield and high purity by means of a '3 +2 +2 +2' fragment condensation method. The synthesis method is environmentally friendly, mild, and free of any highly toxic and poisonable reagents. The cost is greatly reduced and the synthesis method is very suitable for large-scale production.

专利号:US-9206222-B2
优先权日:2009-06-29
标题:Solid phase peptide synthesis of peptide alcohols
发明人：CAUSSIL-AMBLARD MURIEL; MARTINEZ JEAN; TAILHADES JULIEN
权利人:CAUSSIL-AMBLARD MURIEL; MARTINEZ JEAN; TAILHADES JULIEN; CENTRE NAT RECH SCIENT
摘要:The present invention relates to the synthesis of depsipeptides on solid phase support. Said depsipeptides are then implicated in a solution phase O—N acyl shift enabling to obtain the corresponding peptide alcohols.

专利号:US-4351762-A
优先权日:1981-03-10
标题:Rapid, quantitative peptide synthesis using mixed anhydrides
发明人：VERLANDER MICHAEL S; FULLER WILLIAM D; GOODMAN MURRAY
权利人:BIORESEARCH INC
摘要:In the synthesis of a polypeptide chain wherein an N alpha -urethane-protected amino acid mixed anhydride is coupled with an amino-unprotected second amino acid, the improvement comprising conducting said coupling at room temperature or above. This method provides rapid, essentially quantitative reactions without the necessity for reduced temperatures. The method is particularly useful in the solid-phase synthesis of peptides where shortened coupling cycles and improved yields of substantially pure products are obtained.

专利号:US-8710220-B2
优先权日:2009-12-10
标题 :Synthesis of 8-amino boron dipyrromethenes having blue fluorescence
发明人：PE A CABRERA EDUARDO; AZAEL CÉSAR FERNANDO; FLORES JUAN ORLANDO
权利人:PE A CABRERA EDUARDO; AZAEL CÉSAR FERNANDO; FLORES JUAN ORLANDO; UNIV GUANAJUATO
摘要:A family of six 8-amino boron dipyrromethenes having Formulas 1, 2, 3, 4, 6, and 7 has been prepared. The presence of the amine group alters the emission properties of the boron dipyrromethene, such that these compounds are characterized by unexpected blue fluorescence, providing for potential use as lasers. The compound having formula 1 has very high quantum yield. The 8-amino boron dipyrromethenes are prepared in a straightforward, high yield synthesis by substituting an amine group for the thiomethyl group at the 8 position in 8-thiomethyl boron dipyrromethene. The compounds having Formulas 6 and 7 may be used to incorporate peptides and proteins, thus providing biomolecules marked with fluorescent fragments.

专利号:US-8217142-B2
优先权日:1996-07-17
标题 :Liquid phase peptide synthesis of KL-4 pulmonary surfactant
发明人：ABDEL-MAGID AHMED F; EGGMANN URS; MARYANOFF CYNTHIA ANNE; THALER ADRIAN; VILLANI FRANK J
权利人:ABDEL-MAGID AHMED F; EGGMANN URS; MARYANOFF CYNTHIA ANNE; THALER ADRIAN; VILLANI FRANK J; ORTHO PHARMA CORP
摘要:The invention relates to improved liquid phase processes for the preparation of the 21 residue protein component, (Lys-Leu 4 ) 4 -Lys, of the pulmonary surfactant KL-4. These process are amenable to large scale synthesis and one process employs a method of saponifying an ester which reduces the inherent racemization of the α-carbon.

专利号:US-2024182642-A1
优先权日:2022-11-23
标 题:Green synthesis of amino acid based poly(ester urea)s
发明人：OLSEN BRADLEY DAVID; FRANSEN KATHARINA
权利人:MASSACHUSETTS INST TECHNOLOGY
摘要:Disclosed are methods of synthesizing poly(ester urea)s.