CAS: 85068-33-3; 3,5-Bis(Trifluoromethyl)Phenylacetic Acid

上下游产品

CAS号328-70-1 1,3-双(三氟甲基)-5-溴苯 | CAS号108-59-8 丙二酸二甲酯 | CAS号725-89-3 3,5-双(三氟甲基)苯甲酸 | CAS号785-56-8 3,5-双(三氟甲基)苯甲酰氯 | CAS号174083-39-7 3,5-双三氟甲基苯乙酰氯 | CAS号144632-97-3 2-(3, 5-双(三氟甲基)... | CAS号93427-28-2 2-(3,5-双(三氟甲基)苯基)乙醇

3,5-双三氟甲基苯乙炔置于正丁基锂,Oxone||potassium Monopersulfate Triple Salt,水体系中,用 四氢呋喃,正己烷,丙酮 作为反应溶剂,化学反应 15.0H,反应生成 3,5-双(三氟甲基)苯乙酸
参考文献:炔基硼酸酯氧化成羧酸,酯和酰胺.
标题:炔基硼酸酯氧化成羧酸,酯和酰胺.
摘要:已经开发了一种通用有效的方案,用于通过直接从末端炔烃反应生成的炔基硼酸酯的氧化来合成羧酸,酯和酰胺.该协议代表c(sp)-B键氧化的第一个例子.该方法显示出广泛的底物范围,包括芳基和烷基炔烃,并且具有出色的官能团耐受性.水,伯醇和仲醇以及胺是适合这种转化的亲核试剂.值得注意的是,氨基酸和肽可用作亲核试剂,为合成和修饰肽提供了一种有效的方法.药物分子的制备进一步强调了该方法的实用性.
DOI:10.1002/anie.202000988

专利信息

专利号:US-6664282-B2
优先权日:1999-09-17
标 题:Synthesis of [3,5,7]-1H-imidazo [1,5-a]imidazol-2 (3H)- one compounds
发明人：ELABDELLAOUI HASSAN M; OSTRESH JOHN M; HOUGHTEN RICHARD A
权利人:TORREY PINES INST
摘要:Individual substituted [3,5,7]-1H-imidazo[1,5-a]imidazol-2(3H)-one compounds and their pharmaceutically-acceptable salts are disclosed, as are libraries of such compounds. Methods of preparing and using the libraries of compounds as well as individual compounds of the libraries are also disclosed.

专利号:US-5856107-A
优先权日:1997-02-04
标 题 :Combinatorial libraries of imidazol-pyrido-indole and imidazol-pyrido-benzothiophene derivatives, methods of making the libraries and compounds therein
发明人：OSTRESH JOHN M; HOUGHTEN RICHARD A
权利人:TREGA BIOSCIENCES INC
摘要:The invention provides a rapid approach for combinatorial synthesis and screening of libraries of imidazol-pyrido-indole and imidazol-pyrido-benzothiophene compounds. The present invention further provides methods of preparing the libraries and the individual compounds made by the combinatorial synthesis.

专利号:US-5786448-A
优先权日:1996-11-07
标题:Combinatorial libraries of cyclic urea and cyclic thiourea derivatives and compounds therein
发明人：NEFZI ADEL; OSTRESH JOHN M; HOUGHTEN RICHARD
权利人:TREGA BIOSCIENCES INC
摘要:The invention provides a rapid approach for combinatorial synthesis and screening of libraries of cyclic urea and cyclic thiourea compounds. The present invention further provides the compounds made by the combinatorial synthesis.

专利号:US-6531470-B1
优先权日:1998-01-23
标题:Oxazolidinone combinatorial libraries, compositions and methods of preparation
发明人：GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V; NI ZHI-JIE; GORDON ERIC
权利人:UPJOHN CO
摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.

专利号:US-6809202-B2
优先权日:1996-11-07
标 题 :Diketodiazacyclic compounds, diazacyclic compounds and combinatorial libraries thereof
发明人：NEFZI ADEL; OSTRESH JOHN M; HOUGHTEN RICHARD A
权利人:TORREY PINES INST
摘要:The synthesis of individual di- and tri-substituted-1,4-diazacyclic compounds having 6- to 8-atoms in the cyclic ring, their corresponding 1,6-diketo-2,5-diazacyclic compounds and similar 1,4-diazacyclic ring compounds having one ring carbonyl gorup and 6-8 atoms in the ring is disclosed, as are libraries of such compounds. Methods of preparing and using the libraries of compounds as well as individual compounds of the libraries are also disclosed.

专利号:US-6562844-B2
优先权日:1998-01-23
标 题:Oxazolidinone combinatorial libraries, compositions and methods of preparation
发明人：GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V; NI ZHI-JIE; GORDON ERIC
权利人:UPJOHN CO
摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.