CAS: 115-41-3; Catechol Violet Indicator (4.0-7.0)

上下游产品

CAS号120-80-9 邻苯二酚 | CAS号81-08-3 2-磺基苯甲酸酐

2-磺基苯甲酸酐,邻苯二酚 以 磷酸 用作溶剂,以29%的收率获得儿茶酚紫
参考文献:Solvent-Free Synthesis Of Sulfonephthaleins,Sulfonefluoresceins And Fluoresceins Under Microwave Irradiation
标题:Solvent-Free Synthesis Of Sulfonephthaleins,Sulfonefluoresceins And Fluoresceins Under Microwave Irradiation
摘要:报道了一种高效的无溶剂合成磺酮邻苯二甲酸酯,磺酮荧光素和荧光素的方法,在微波辐射下进行.
Doi:10.1135/cccc20021779

专利信息

专利号:US-12007376-B2
优先权日:2014-02-26
标题 :Method for determining a concentration of a synthesis component in a radiopharmaceutical sample
发明人：LEBEDEV ARTEM Y; ELIZAROV ARKADIJ M
权利人:TRACE ABILITY INC
摘要:A method for determining a concentration of a synthesis component in a radiopharmaceutical sample comprises providing an indicator, a metal or a metal complex, contacting the radiopharmaceutical sample with the indicator, metal or metal complex for a period of time sufficient to obtain an interaction, measuring an optical characteristic of the interacted components, and determining a concentration of the synthesis component in the radiopharmaceutical sample based on the measured optical characteristic.

专利号:US-2024208898-A1
优先权日:2021-03-25
标 题 :Enamine n-oxides: synthesis and application to hypoxia-responsive prodrugs and imaging agents
发明人：KIM JUSTIN; KANG DAHYE; CHEUNG SHELDON T
权利人:DANA FARBER CANCER INST INC
摘要:Disclosed are compounds and pharmaceutically acceptable salts and stereoisomers thereof that are suitable for diagnosis and the treatment of diseases and disorders characterized by, associate with or which exhibit tissue hypoxia, such as, for example, solid tumors. Also disclosed are pharmaceutical compositions containing same, and methods of making and using the compounds.

专利号:WO-2024263911-A9
优先权日:2023-06-22
标题 :Methods for the synthesis and linearization of peptidomimetic macrocycles
发明人：KIM JUSTIN; FOWLER ELAINE
权利人:DANA FARBER CANCER INST INC
摘要:Disclosed are methodologies for the macrocyclization and linearization of peptides.

专利号:US-8962279-B2
优先权日:2009-12-30
标题:Solid-phase chelators and electronic biosensors
发明人：LIU DAVID J; SU XING; WU KAI
权利人:LIU DAVID J; SU XING; WU KAI; INTEL CORP
摘要:Methods for sequencing nucleic acids are presented. Sequencing is accomplished through the chemical amplification of the products of DNA synthesis and the detection of the chemically amplified products. In embodiments of the invention, a substrate is provided having a plurality of molecules of DNA to be sequenced attached and a plurality of molecules capable of chelating pyrophosphate ions attached, the DNA molecules to be sequenced are primed, and a next complementary nucleotide is incorporated and excised a plurality of times leading to the buildup of pyrophosphate ions locally around the DNA molecule to be sequenced. Pyrophosphate ions are captured by the substrate-attached chelators and electronically detected to determine the identity of the next complementary nucleic acid in the DNA molecule to be sequenced. Additionally, devices and methods are provided for detecting biomolecules through the detection of pyrophosphate ions.

专利号:US-2025069787-A1
优先权日:2021-11-25
标 题:Method for preparing acid resistant magnetic particles and acid resistant magnetic particles
发明人：SILVESTRE MARTIN EDUARDO; EISOLD SABINE; HEINDL DIETER; PETERS KRISTINA
权利人:ROCHE DIAGNOSTICS OPERATIONS INC
摘要:In a first aspect, the invention relates to a method for preparing a magnetic bead comprising at least one magnetic particle (M) and a silica coating, wherein the silica coating comprises at least two silica layers, the method comprising steps (a) to (d), wherein at least one of steps (b), (c) and (d) is/are done under sonication, wherein sonication is done with an amplitude (peak-to-peak) in the range of from 50 to 250 μm. A second aspect of the invention is related to a magnetic bead comprising (i) at least one magnetic particle (M) and (ii) a silica coating, wherein the silica coating comprises at least two silica layers; wherein the magnetic bead is stable against 7.5 M hydrochlorid acid and has a metal (cation) leaching rate in 7.5 M hydrochloric acid in the range of from 0.1 to 10%, wherein the metal (cation) leaching is determined according to a complex formation of Fe2+ with bathophenanthroline according to Reference Example 8.2. In a third aspect, the invention relates to a functionalized magnetic bead comprising at least one, magnetic bead according to the second aspect, wherein an outer silica layer is functionalized with at least one group selected from the group consisting of amino group, azide group, alkyne group, carboxyl group, thiol group, epoxy group, aryl group and alkyl group. A fourth aspect of the invention is directed to a process for functionalizing a magnetic bead according to the second aspect comprising at least one magnetic particle (M) and a silica coating, wherein the silica coating comprises at least two silica layers. A fifth aspect of the invention is related to a method for preparing magnetic Fe3O4 supra particles and a sixth aspect relates to the use of a magnetic bead according to the second aspect or of a functionalized according to the fourth aspect for immobilization of acid stable biocatalysts or for solid-phase organic synthesis using acid-stable linker.

专利号:US-9671558-B2
优先权日:2009-06-30
标题 :Chemically induced optical signals and DNA sequencing
发明人：SU XING; WANG LIMING; LIU JIANQUAN; WU KAI
权利人:SU XING; WANG LIMING; LIU JIANQUAN; WU KAI; INTEL CORP
摘要:Methods for sequencing nucleic acids are presented. Sequencing is accomplished through the chemical amplification of the products of DNA synthesis and the detection of the chemically amplified products. In embodiments of the invention, a substrate is provided having a plurality of molecules of DNA to be sequenced attached and a plurality of molecules capable of chelating pyrophosphate ions attached, the DNA molecules to be sequenced are primed, and a next complementary nucleotide is incorporated and excised a plurality of times leading to the buildup of pyrophosphate ions locally around the DNA molecule to be sequenced. Pyrophosphate ions are captured by the substrate-attached chelators and optically detected to determine the identity of the next complementary nucleic acid in the DNA molecule to be sequenced.