CAS: 13745-17-0; 4-Bromo-1H-Pyrazole-3-Carboxylic Acid

相似化合物

5932-34-3 81190-89-8 288246-16-2

上下游产品

吡唑-3-甲酸 1H-Pyrazole-3-Carboxylic Acid 1621-91-6

4-溴-1-苯基磺酰基吡唑-5-羧酸置于氢氧化钾体系中,用 甲醇 用作溶剂,化学反应 1.0H,以60%的收率获得4-溴-1H-吡唑-3-甲酸
参考文献:Heinisch,Gottfried; Holzer,Wolfgang; Pock,Sabine,Journal Of The Chemical Society. Perkin Transactions I,1990,# 7,P. 1829-1834
标题:Heinisch,Gottfried; Holzer,Wolfgang; Pock,Sabine,Journal Of The Chemical Society. Perkin Transactions I,1990,# 7,P. 1829-1834

专利信息

专利号:EP-2607355-A1
优先权日:2011-12-23
标 题:Synthesis of triazolopyrimidine compounds
权利人:LEK PHARMACEUTICALS
摘要:The present invention relates to the field of organic synthesis and describes the synthesis of specific intermediates suitable for the preparation of triazolopyrimidine compounds such as ticagrelor.

专利号:EP-2666771-A1
优先权日:2012-05-24
标题 :Synthesis of Aminocyclopentanetriol Derivatives
发明人：STERK DAMJAN; CASAR ZDENKO
权利人:LEK PHARMACEUTICALS
摘要:The present invention relates to the field of organic synthesis and describes the synthesis of specific intermediates suitable for the preparation of triazolopyrimidine compounds such as ticagrelor. nThe present invention provides in particular a process for the preparation of a compound of formula Vn ncomprising: na) providing a compound of formula IVn n, and nb) reducing the compound of formula IV with activated zinc in the presence of copper to give the compound of formula V.

专利号:US-9278972-B2
优先权日:2011-12-23
标题 :Synthesis of triazolopyrimidine compounds
发明人：MARAS NENAD; GAZIC SMILOVIC IVANA; STERK DAMJAN
权利人:LEK PHARMACEUTICALS
摘要:The present invention relates to the field of organic synthesis and describes the synthesis of specific intermediates suitable for the preparation of triazolopyrimidine compounds such as ticagrelor.

专利号:US-7001625-B2
优先权日:2001-07-30
标 题:Solid phase synthesis of salts of organic acids including butyric acid
发明人：VAN DYCK STEFAAN; ADAMS CLIFFORD; MEEUSEN ANDRE; VAN CAMPENHOUT LEEN
权利人:KEMIN IND INC
摘要:A process for the solid-phase synthesis of salts of organic acids in a granular, free-flowing, and dust-free form particularly suited for use as animal feed additives. A mixture of liquid organic acids, including butyric acid, is applied to an inert, absorbent carrier. A solid base is then added during stirring. The acid is slowly released from the carrier preventing the fast reactions that lead to the formation of clumps. The exothermic reaction releases heat which assists in reducing the moisture content of the product. The addition of butyric acid results in a product which has an improved effect on animal growth over the animal feed additive without the addition of butyric acid.

专利号:US-6986909-B2
优先权日:2001-07-30
标 题 :Solid phase synthesis of salts of organic acid
发明人：VAN DYCK STEFAAN
权利人:KEMIN IND INC
摘要:A process for the solid-phase synthesis of salts of organic acids in a granular, free-flowing, and dust-free form particularly suited for use as animal feed additives. A liquid organic acid is applied to an inert, absorbent carrier. A solid base is then added during stirring. The acid is slowly released from the carrier preventing the fast reactions that lead to the formation of clumps. The exothermic reaction releases heat which assists in reducing the moisture content of the product.

专利号:US-2008255359-A1
优先权日:2005-09-28
标题:Novel Chemical Process For the Synthesis of Quinoline Compounds
发明人：WADE CHARLES EDWARD
权利人:WADE CHARLES EDWARD
摘要:Disclosed is a novel, simplified and economic process for making 3-phenylsulphonyl quinolines with an amine group at position 8 of the quinoline ring system, including 3-phenylsulfonyl-8-piperazin-1-yl-quinoline in particular, in the absence of a palladium catalyst. Also disclosed is the crystallization of polymorphic forms of 3-phenylsulfonyl-8-piperazin-1-yl-quinoline.