CAS: 14267-92-6; 5-Chloro-1-Pentyne

相似化合物

51908-64-6 10297-06-0 18804-36-9

上下游产品

CAS号5390-04-5 4-戊炔-1-醇 | CAS号1066-26-8 乙炔化钠,二甲苯溶液 | CAS号109-70-6 1-溴-3-氯丙烷 | CAS号74-86-2 乙炔 | CAS号7664-41-7 氨 | CAS号37490-32-7 (E)-(5-氯戊-1-烯-1-基)硼酸 | CAS号543-59-9 氯代正戊烷 | CAS号4224-62-8 6-氯己酸 | CAS号143903-04-2 8-iodo°Cta-2,4-diene | CAS号18690-56-7 2-(1-苄-2-甲基-1H-... | CAS号96-48-0 γ-丁内酯 | CAS号77758-51-1 5-己炔酸甲酯 | CAS号5891-21-4 5-氯-2-戊酮 | CAS号20074-80-0 5-氯戊醛 | CAS号209414-27-7 (S)-1-(2-氨基-5-氯...

4-戊炔-1-醇置于n,N'-二甲基硫脲,N-氯代丁二酰亚胺体系中,用 二氯甲烷 用作溶剂,化学反应 1.0H,以72%的收率获得5-氯戊炔
参考文献:硫脲介导的醇卤化反应.
标题:硫脲介导的醇卤化反应.
摘要:提出了在亚化学计量的硫脲添加剂的存在下加速的在温和条件下醇的卤化.硫脲的添加量决定了反应的途径,该途径可能与所需的卤化反应不同,在没有硫脲的情况下朝着醇的氧化,或者在使用过量的硫脲时朝着原料的回收.溴化和氯化对于伯醇,仲醇,叔醇和苄醇都非常有效,并且可以耐受各种官能团.详细的电子顺磁共振(epr)研究,同位素标记和其他对照实验表明,基于自由基的机理.反应是在环境条件下进行的,使用的试剂普遍存在且价格便宜,具有广泛的应用范围,并且可以实现高度原子经济,
Doi:10.1021/acs.Joc.0C01431

专利信息

专利号:US-2023312617-A1
优先权日:2020-07-25
标题 :Process for synthesis of organosilicon compounds from halosilanes
发明人：DOLAI SUKANTA; BHAT SHREEDHAR; TARAFDAR GOURAV
权利人:MOMENTIVE PERFORMANCE MAT INC
摘要:A process for synthesis of an organosilicon compound is provided herein. Also, novel organosilicon compounds prepared by the present process is provided herein. The process comprises the reaction of a halosilane with an organofunctional alkyl halide in the presence of a metal catalyst, a promoter, and an optional co-catalyst. The process provides an efficient synthetic route to produce organosilicon compounds. The process also allows synthesis of organosilicon compounds with a plurality of different functional groups.

专利号:US-2025026768-A1
优先权日:2023-06-30
标题:Method for the synthesis of axially chiral organoboron compounds
发明人：PING YIFAN; CHE CHI-MING
权利人:LABORATORY FOR SYNTHETIC CHEMISTRY AND CHEMICAL BIOLOGY LTD
摘要:A highly efficient and atroposelective Rh-catalyzed [2+2+2] cycloaddition for the synthesis of axially chiral aryboron compounds is developed. The reactions of diynes and alkynylborons smoothly occur in an atom-economical manner, affording a variety of C—B atropisomers in excellent yields and enantioselectivities. The protocol features mild conditions, broad substrate scope, and good functional tolerance. The obtained C—B atropisomers show powerful synthetic applications in terms of producing novel chiral phosphine ligands.

专利号:US-6028237-A
优先权日:1996-12-16
标题:Synthesis of cyclopropylacetylene
发明人：PARSONS JR RODNEY LAWRENCE
权利人:DU PONT PHARM CO
摘要:The present invention relates generally to novel methods for the synthesis of cyclopropylacetylene which is a reagent in the asymmetric synthesis of (S)-6-chloro-4-cyclopropylethynyl-4-trifluoromethyl-1,4-dihydro-2H-3,1-benzoxazin-2-one which is a useful human immunodeficiency virus (HIV) reverse transcriptase inhibitor.

专利号:US-5698741-A
优先权日:1995-05-25
标题 :Asymmetric synthesis of (-)6-chloro-4-cyclopropyl-ethynyl-4-trifluoromethyl-1,4-dihydro-2H-3,1-benzoxazin-2-one
发明人：THOMPSON ANDREW S; CORLEY EDWARD G; GRABOWSKI EDWARD J J; YASUDA NOBUYOSHI
权利人:MERCK & CO INC
摘要:An improved synthesis of a highly potent HIV reverse transcription inhibitor is disclosed, involving an acetylide and a trifluoromethyl ketone which produces a chiral product in the presence of a chiral amino alcohol.

专利号:US-5663467-A
优先权日:1995-01-23
标题:Synthesis of cyclopropylacetylene
发明人：THOMPSON ANDREW S; CORLEY EDWARD G; HUNTINGTON MARTHA
权利人:MERCK & CO INC
摘要:An improved synthesis of cyclopropylacetylene involving cyclization of 5-halo-1-pentyne in strong base is disclosed, and is useful for preparing compounds with a cyclopropylethynyl substituent, such as an intermediate for a highly potent HIV reverse transcriptase inhibitor or other pharmaceutically active compounds.

专利号:WO-9804535-A1
优先权日:1996-07-26
标 题 :A practical synthesis of benzoxazinones useful as hiv reverse transcriptase inhibitors
发明人：PIERCE MICHAEL ERNEST; RADESCA LILIAN ALICIA
权利人:DU PONT MERCK PHARMA
摘要:The present invention describes novel methods for the synthesis of benzoxazinone compounds which are useful as human immunodeficiency virus (HIV) reverse transcriptase inhibitors. The benzoxazinone of formula (VI-a) is particularly effective in the treatment of HIV.