CAS: 146954-74-7; 1-((2R,3R,4R,5R)-5-((Bis(4-Methoxyphenyl)(Phenyl)Methoxy)Methyl)-3-Fluoro-4-Hydroxytetrahydrofuran-2-yl)Pyrimidine-2,4(1H,3H)-Dione

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23669-79-6 103285-22-9 81246-79-9

上下游产品

CAS号40615-36-9 4,4'-二甲氧基三苯基氯甲烷 | CAS号146954-75-8 DMT-2′Fluoro-dU...

三氯化苄置于aluminum (III) Chloride,Copper(II) Nitrate体系中,用 二氯甲烷 用作溶剂,化学反应 6.0H,反应生成5'-O-[双(4-甲氧基苯基)(苯基)甲基]-2'-脱氧-2'-氟尿苷
参考文献:硝酸铜 (II) 催化区域选择性保护伯醇与核苷和碳水化合物中的 4,4'-二甲氧基三苯甲基和 2,7-二甲基-9-苯基呫吨-9-基
标题:硝酸铜 (II) 催化区域选择性保护伯醇与核苷和碳水化合物中的 4,4'-二甲氧基三苯甲基和 2,7-二甲基-9-苯基呫吨-9-基
摘要:摘要 在作为路易斯酸催化剂的硝酸铜 (II) 存在下,使用二甲氧基三苯甲醇 (Dmtr-Oh) 或二甲基苯甲醇 (Dmpx-Oh) 实现了核苷和碳水化合物类似物中伯羟基的区域选择性保护.观测到优异的选择性保护伯羟基而不是仲羟基,而糖苷键不受影响.通过脂肪族无环和环状二醇的 Dmtr 和 Dmpx 保护进一步举例说明了该方法的实用性.
Doi:10.1080/15257770.2018.1460480

专利信息

专利号:US-10730904-B2
优先权日:2012-11-14
标 题:Method for liquid-phase synthesis of nucleic acid
发明人：NONOGAWA MITSURU; NAGATA TOSHIAKI; SAITO HIDEKI; YASUMA TSUNEO
权利人:TAKEDA PHARMACEUTICALS CO
摘要:In this method, an oligonucleotide represented by formula (II) [wherein Y 1 , Q, Base, r and r′ are each as defined in claim 1 ] is prepared by using, as a synthesis unit, a novel nucleoside monomer compound represented by formula (I) [wherein X, R 1 , Y, Base, Z, Ar, R 2 , R 3 and n are each as defined in claim 1 ]. The novel nucleoside monomer compound is a nucleoside, the base moiety of which is substituted with an aromatic-hydrocarbon-ring-carbonyl or -thiocarbonyl group having at least one hydrophobic group. The method can dispense with column-chromatographic purification in every reaction, and enables base elongation not only in the 3′-direction but also in the 5′-direction, thus attaining efficient liquid-phase mass synthesis of an oligonucleotide.

专利号:US-2019135852-A1
优先权日:2012-11-14
标题 :Method for liquid-phase synthesis of nucleic acid

专利号:EP-2921499-A1
优先权日:2012-11-14
标 题 :Method for liquid-phase synthesis of nucleic acid

专利号:EP-2921499-B1
优先权日:2012-11-14
标 题 :Method for liquid-phase synthesis of nucleic acids

专利号:JP-6218333-B2
优先权日:2012-11-14
标 题 :Method for liquid phase synthesis of nucleic acids

专利号:CN-104918949-B
优先权日:2012-11-14
标 题 :Solution-phase Synthesis of Nucleic Acids