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16689-35-3 7400-27-3 221024-42-6欧盟法规
ECHA物质C&L通报REACH预注册上下游产品
1-isopropylhydrazinecarboxylic acid tert-butyl ester tert-butyl 2-(isopropyl)hydrazinecarboxylate 1-(isopropyl)-2-tert-butoxycarbonylhydrazine acetate tert-butyl isopropylidenecarbazate3)2Z-Leu-HN-NH-CH(CH3)2 2)-HN-NH-CH(CH3)2Z-Glu(NH2)-HN-NH-CH(CH3)2 2-甲基-2-丙基2-异亚丙基肼羧酸酯置于甲醇,Sodium Cyanoborohydride,盐酸体系中,用 四氢呋喃,水 用作溶剂,化学反应 3.17H,反应生成异丙基肼盐酸盐
参考文献: Protein Kinase Inhibitors[fr] Inhibiteurs De Protéine Kinases
标题: Protein Kinase Inhibitors[fr] Inhibiteurs De Protéine Kinases
摘要:本发明涉及一种新型的蛋白激酶抑制剂家族.具体而言,本发明涉及tec和src蛋白激酶家族成员的抑制剂.
专利信息
专利号:US-8283476-B2
优先权日:2007-06-26
标 题:Transition metal catalyzed synthesis of 2H-indazoles
发明人:HALLAND NIS; NAZARE MARC; LINDENSCHMIDT ANDREAS; ALONSO JORGE; RKYEK OMAR; URMANN MATTHIAS
权利人:HALLAND NIS; NAZARE MARC; LINDENSCHMIDT ANDREAS; ALONSO JORGE; RKYEK OMAR; URMANN MATTHIAS; SANOFI SA
摘要:The present invention relates to a process for the regioselective synthesis of compounds of the formula I, n nwherein R0; R1; R2; R3; R4; R5; A1; A2; A3; A4, Q and J have the meanings indicated in the claims. The present invention provides a direct transition metal catalyzed process to a wide variety of multifunctional 2H-indazoles or 2H-azaindazoles of the formula (I) from 2-halo-phenylacetylenes or (2-sulfonato)phenylacetylenes and monosubstituted hydrazines.
专利号:WO-2021224280-A1
优先权日:2020-05-05
标题:Synthesis of a sickle cell disease agent and intermediates thereof
发明人:JUDGE THOMAS; SCHROEDER MEL C; KOPEL LUCAS C; EKLOV BRIAN M
权利人:DIPHARMA FRANCIS SRL
摘要:New processes for preparing 2-hydroxy-6-((2-(1-isopropyl-1H-pyrazol-5- yl)pyridin-3-yl)methoxy)benzaldehyde, an agent developed for the treatment of sickle cell disease, and intermediates thereof, are provided herein.
专利号:US-9919064-B2
优先权日:2012-08-10
标 题 :Compositions, methods, and systems for the synthesis and use of imaging agents
发明人:CESATI RICHARD R; RADEKE HEIKE S; PANDEY SURESH K; PUROHIT AJAY; ROBINSON SIMON P
权利人:LANTHEUS MEDICAL IMAGING INC
摘要:The present invention provides compounds with imaging moieties for imaging a subject. The present invention also relates to systems, compositions, and methods for the synthesis and use of imaging agents, or precursors thereof. An imaging agent precursor may be converted to an imaging agent using the methods described herein. In some cases, a composition or plurality of imaging agents is enriched in 18 F. In some cases, an imaging agent may be used to image an area of interest in a subject, including, but not limited to, the heart, cardiovascular system, cardiac vessels, brain, and other organs.
专利号:US-9938278-B2
优先权日:2014-12-17
标题 :FXR (NR1H4) modulating compounds
发明人:GEGE CHRISTIAN; KREMOSER CLAUS; KINZEL OLAF; BLOMGREN PETER A; CURRIE KEVIN S; KROPF JEFFREY E; SCHMITT AARON C; WATKINS WILLIAM J; XU JIANJUN
权利人:GILEAD SCIENCES INC
摘要:The present invention relates to compounds which bind to the NR1H4 receptor (FXR) and act as agonists of FXR. The invention further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding of said nuclear receptor by said compounds and to a process for the synthesis of said compounds.
专利号:US-2010234601-A1
优先权日:2007-06-26
标 题 :Transition metal catalyzed synthesis of 2H-indazoles
专利号:WO-2009000411-A1
优先权日:2007-06-26
标 题 :A transition metal catalyzed synthesis of 2h-indazoles