CAS: 18952-87-9; 1-Isopropyl-1H-Pyrazole

相似化合物

15754-60-6 2817-71-2 313350-82-2

上下游产品

CAS号288-13-1 吡唑 | CAS号75-26-3 2-溴丙烷 | CAS号313350-82-2 1-异丙基-4-碘吡唑 | CAS号839714-33-9 1-异丙基吡唑-5-硼酸

吡唑,2-溴丙烷置于四丁基溴化铵,Sodium Hydroxide体系中,用 水,二甲基亚砜 用作溶剂,化学反应 8.0H,以90%的收率获得1-异丙基吡唑
参考文献:一个实用的体素合成器
标题:一个实用的体素合成器
摘要:由市售化学品吡唑,2-氯烟酸和二甲氧基苯开发了一种改进的实用合成体素(1) .关键中间体 (2-[1-Isopropyl-1 H-Pyrazol-5-Yl]Pyridin-3-yl) 甲醇(8)经 4 个步骤(包括还原和交叉偶联缩合)以 45% 的收率制备.2,6-二羟基苯甲醛 ( 24 ) 经 2 个步骤以 68% 的收率制备.最后,从这个收敛的合成路线通过 8 个步骤获得1,总产率为 25%,纯度为 99.2%,20 克规模.
Doi:10.1002/jhet.4535

专利信息

专利号:US-8188113-B2
优先权日:2006-09-14
标 题 :Dihydropyridopyrimidinyl, dihydronaphthyidinyl and related compounds useful as kinase inhibitors for the treatment of proliferative diseases
发明人：FLYNN DANIEL L; PETILLO PETER A; KAUFMAN MICHAEL D; PATT WILLIAM C
权利人:FLYNN DANIEL L; PETILLO PETER A; KAUFMAN MICHAEL D; PATT WILLIAM C; DECIPHERA PHARMACEUTICALS INC
摘要:The present invention relates to novel dihydropyridopyrimidinyl, dihydronaphthyridinyl, and related compounds which are kinase inhibitors and modulator useful for the treatment of various diseases. More particularly, the invention is concerned with such compounds, kinase/compound adducts, methods of treating diseases, and methods of synthesis of the compounds. Preferably, the compounds are useful for the modulation of kinase activity of Raf kinases and disease polymorphs thereof. Compounds of the present invention find utility in the treatment of mammalian cancers and especially human cancers including but not limited to malignant melanoma, colorectal cancer, ovarian cancer, papillary thyroid carcinoma, non small cell lung cancer, and mesothelioma. Compounds of the present invention also find utility in the treatment of rheumatoid arthritis and retinopathies including diabetic retinal neuropathy and macular degeneration.

专利号:US-10300471-B2
优先权日:2013-10-08
标题 :Ruthenium-catalyzed synthesis of biaryl compounds in water
发明人：KOOHANG ALI AIDEN; MEHTA ANITA
权利人:CHICAGO DISCOVERY SOLUTIONS LLC
摘要:Using a [RuCl 2 (arene)] 2 complex and a formate source, a directed ortho C—H insertion and aryl-aryl coupling sequence in water provides biaryl compounds useful in the preparation of biologically active molecules and intermediates. Reactions may be conducted in the ambient atmosphere. Ruthenium catalysts prepared from [RuCl 2 (arene)] 2 and a formate source may be prepared in situ or isolated for later use.

专利号:US-12054833-B2
优先权日:2020-07-29
标 题:Catalyst for synthesizing organic carbonate and method of producing thereof, electrode for synthesizing organic carbonate, cell for synthesizing organic carbonate, method of producing organic carbonate, and synthesis system
发明人：FUJINUMA NAOHIRO
权利人:SEKISUI CHEMICAL CO LTD
摘要:An organic carbonate synthesis catalyst for electrochemically synthesizing an organic carbonate from carbon monoxide, comprises: an active particle containing a metal element; and a porous carbon supporting the active particle.

专利号:US-2024239768-A1
优先权日:2021-04-27
标题 :Method for preparing xanthine oxidase inhibitor
发明人：RYU IN AE; LEE JU YOUNG; YOON JOO YONG; LEE SEOK JU; PARK AH BYEOL; KIM KI DAE; JEONG HUI RAK
权利人:LG CHEMICAL LTD
摘要:The present invention relates to a novel preparation method that can be advantageously utilized for the synthesis of a xanthine oxidase inhibitor of Chemical Formula 1.

专利号:US-12215435-B2
优先权日:2021-09-09
标 题 :Electrochemical cell, method for producing carbonyl compound, and synthesis system
发明人：FUJINUMA NAOHIRO
权利人:SEKISUI CHEMICAL CO LTD
摘要:The electrochemical cell is an electrochemical cell which electrochemically synthesizes at least one carbonyl compound selected from the group consisting of organic carbonates and organic oxalates from carbon monoxide, and has an electrolyte solution containing a redox species and a catalyst, and an electrode.

专利号:US-12336981-B2
优先权日:2010-09-03
标题 :Compounds and compositions for the inhibition of NAMPT
发明人：BAIR KENNETH W; BAUMEISTER TIMM R; BUCKMELTER ALEXANDRE J; CLODFELTER KARL H; DRAGOVICH Peter; GOSSELIN FRANCIS; HAN BINGSONG; LIN JIAN; REYNOLDS DOMINIC J; ROTH BRUCE; SMITH CHASE C; WANG ZHONGGUO; YUEN PO-WAI; ZHENG XIAOZHANG
权利人:VALO HEALTH INC; GENENTECH INC
摘要:The present invention relates to compounds and compositions for the inhibition of NAMPT, their synthesis, applications, and antidotes. An illustrative compound of the invention is shown below: