CAS: 2137-18-0; (8R,9S,10R,13S,14S,17R)-17-Acetyl-17-Hydroxy-13-Methyl-1,2,6,7,8,9,10,11,12,14,15,16-Dodecahydrocyclopenta[a]Phenanthren-3-One

上下游产品

CAS号1624-58-4 17α-hydroxy-3-m... | CAS号67519-64-6 16α,17α-epoxy-1... | CAS号111979-17-0 16α,17-epoxy-3-... | CAS号31981-44-9 19-去甲-3,20-二酮-孕... | CAS号1253-28-7 己酸各司孕甾醇

美雌醇置于盐酸,氨,Sodium Methylate,Sodium,对甲苯磺酸,三乙胺,原甲酸三甲酯体系中,用 四氢呋喃,甲醇,乙醇,二氯甲烷,水,叔丁醇 用作溶剂,化学反应 6.33H,反应生成孕诺酮
参考文献:醋酸去甲孕甾醇的改进合成方法
标题:醋酸去甲孕甾醇的改进合成方法
摘要:口服避孕药(ocs)是合成类固醇或孕激素,在结构上与睾丸激素或孕激素有关.已经合成了许多孕激素并批准用于°C,激素替代疗法(hrt)或某些妇科疾病的治疗.醋酸诺美孕酮(nomac)是新批准的°C,并已在许多国家迅速接受oc或hrt.Nomac的合成仍然具有挑战性且成本很高.我们开发了一种新颖且经过改进的合成nomac的方法,共11个步骤,并且在不使用危险试剂的情况下总体收率非常好.
Doi:10.1021/op4003533

专利信息

专利号:US-9562067-B2
优先权日:2013-12-16
标题:Process for the production of 19-norpregn-4-en-3,20-dione-17α-ol(gestonorone) and intermediates therefor
发明人：Csörgei János; HORVÃ?TH ANITA; SÃ?NTA CSABA; Mahó Sándor; BÉNI ZOLTÃ?N; Horváth János
权利人:RICHTER GEDEON NYRT
摘要:The present invention relates to a new stereoselective process for the synthesis of 17(α)-17-acetyl-17-hydroxy-estr-4-en-3-one of formula (I), as well as to the new intermediates of the process. The 17(α)-17-acetyl-17-hydroxy-estr-4-en-3-one (gestonorone) is an important intermediate in the synthesis of the active ingredients having progestogen activity—such as gestonorone capronate and nomegestroi acetate. Formulas (I), (II) and (III).

专利号:BR-112016013759-B1
优先权日:2013-12-16
标 题:PROCESS FOR SYNTHESIS OF A COMPOUND, AND, COMPOUND

专利号:US-3517034-A
优先权日:1968-03-05
标题 :Synthesis of 4-oxa steroids
发明人：KRAKOWER GERALD W
权利人:SQUIBB & SONS INC

专利号:BR-112016013759-A2
优先权日:2013-12-16
标 题 :PROCESS FOR THE SYNTHESIS OF A COMPOUND AND COMPOUND

专利号:JP-2017501159-A
优先权日:2013-12-16
标题 :19-norpregna-4-ene-3,20-dione-17. α. -Synthesis method of all (guest norone) and intermediates thereof

专利号:JP-6453337-B2
优先权日:2013-12-16
标题:19-norpregna-4-ene-3,20-dione-17. α. -Synthesis method of all (guest norone) and intermediates thereof