CAS: 2448-45-5; ((Benzyloxy)Carbonyl)-D-Phenylalanine

该化合物是D-苯麻尼的一种受保护衍生物,广泛用于peptide合成和制药研究;苯氧基碳基(Z)组是一个有效的防雷运动,在合成程序期间加强稳定性,同时允许在温和条件下有选择地取消保护;其个性D配置对于构建对抗性纯化peptide和研究立体相互作用特别宝贵.Z-D-Phe在普通有机溶剂中表现出高度溶性,便于将其纳入复杂的合成途径;该化合物经常用于固相聚聚丙基苯并用作生物活性peptide类的合成(SPS)和建筑构件.其一贯的纯度和可靠性表现使需要精确控制peptide结构的研究人员更愿意选择.

结构式图片

相似化合物

3588-57-6 1161-13-3 13734-34-4

上下游产品

CAS号673-06-3 D-苯丙氨酸 | CAS号501-53-1 氯甲酸苄酯 | CAS号2578-85-0 Z-D-苯丙氨酸 | CAS号565234-20-0 benzyl (2S,3R,5... | CAS号247259-40-1 N-Cbz-O-benzyl ... | CAS号247050-08-4 benzyl N-[(2S)-... | CAS号565234-16-4 (2S,3R)-benzyl ... | CAS号565234-15-3 benzyl (2S,3R,6... | CAS号64-17-5 乙醇 | CAS号3588-57-6 CBZ-DL-苯丙氨酸 | CAS号17350-84-4 2-甲基-D-苯丙氨酸 | CAS号673-06-3 D-苯丙氨酸 | CAS号23239-35-2 a-甲基-L-苯丙氨酸 | CAS号2578-85-0 Z-D-苯丙氨酸 | CAS号63219-70-5 N-cbz-d-苯丙氨醛 | CAS号58607-69-5 D-苯丙氨酰-D-苯丙氨酸 | CAS号58970-76-6 乌苯美司 | CAS号58917-85-4 N-苄氧羰基-D-苯丙氨醇 | CAS号3397-36-2 Z-D-苯丙氨酸N-羟基琥珀酰亚胺酯 | CAS号153223-21-3 (4R,5S,6S,7R)-4...

合成工艺路线路线简述

    N-Cbz-D-苯丙氨醛置于chromium(Vi) Oxide,硫酸体系中,用 水,丙酮 用作溶剂,化学反应生成N-苄氧羰基-D-苯丙氨酸
    参考文献:Asymmetric Carbon To Nitrogen Bond Formation Using Optically-Active Allylic Selenides: A New General Method For The Synthesis Of N-Protected Optically-Active .Alpha.-Amino Acids
    标题:Asymmetric Carbon To Nitrogen Bond Formation Using Optically-Active Allylic Selenides: A New General Method For The Synthesis Of N-Protected Optically-Active .Alpha.-Amino Acids
    摘要:
    Doi:10.1021/jo00203A037

    海关参考信息

    专利信息


    专利号:US-5116741-A
    优先权日:1988-04-12
    标题 :Biosynthetic uses of thermostable proteases
    发明人:BRYAN PHILIP N; PANTOLIANO MICHAEL W; ROLLENCE MICHELE L; WONG CHI H
    权利人:GENEX CORP
    摘要:The invention relates to the novel use of mutants of subtilisin in organic syntheses reactions in non-native environments. Especially the invention relates to methods for the use of mutant subtilisins in organic solvents for the catalysis of reactions involving ester formation and cleavage, including acylations and deacylations, and amidations and deamidations. The methods provide novel strategies which are useful in the synthesis of deoxynucleosides, dideoxynucleosides, peptides, sugars and the like.

    专利号:US-5499193-A
    优先权日:1991-04-17
    标题:Automated synthesis apparatus and method of controlling the apparatus
    发明人:SUGAWARA TOHRU; KATO SHINJI
    权利人:TAKEDA CHEMICAL INDUSTRIES LTD
    摘要:An automatic synthesizing apparatus for continuously effecting automatically by a controlling apparatus all the operations including the supplying of samples into reaction vessel and so on, reaction processing of the contents within the reaction vessels, PH adjustment, extraction/dehydration processing, purification of the contents, and further analysis of the reaction condition so as to produce the target compounds. Many basic unit operation procedures are made and stored so that programs for effecting the operation controlling of the automatic synthesizing apparatus may be extremely easily made. The innumerable syntheses programs in the chemical experiments may be effected simply by the inputting of the operation names of the unit operation procedures in the operational orders when the synthesis order programs may be made for each target compound.

    专利号:EP-0510487-B1
    优先权日:1991-04-17
    标题:Automated synthesis apparatus and method of controlling the apparatus
    发明人:SUGAWARA TOHRU; KATO SHINJI
    权利人:TAKEDA CHEMICAL INDUSTRIES LTD
    摘要:An automatic synthesizing apparatus (I,II) for continuously effecting automatically by a controlling apparatus (II) all the operations including the supplying of samples into reaction vessel and so on, reaction processing of the contents within the reaction vessels (12), PH adjustment (13), extraction/dehydration processing (14), purification (16) of the contents, further analysis (15) of the reaction condition so as to produce the target compounds. Many basic unit operation procedures are made, stored so that programs for effecting the operation controlling of the automatic synthesizing apparatus may be extremely easily made. The innumerable syntheses programs in the chemical experiments may be effected simply by the inputting of the operation names of the unit operation procedures in the operational orders when the synthesis order programs may be made for each target compound.

    专利号:CN-102686601-A
    优先权日:2009-11-16
    标 题 :Synthesis of Ac-Arg-cyclo(Cys-D-Ala-His-D-Phe-Arg-Trp-Cys)-NH2

    专利号:WO-9209620-A1
    优先权日:1990-11-30
    标题 :Solution phase process for synthesis of peptide
    发明人:STEVENSON DAVID
    权利人:SMITHKLINE BEECHAM CORP
    摘要:A solution phase process for preparing L-His-D-Trp-L-Ala-L-Trp-D-Phe-L-Lys-NH2, a peptide which has pituitary growth hormone releasing activity, is described.

    专利号:EP-0564587-A4
    优先权日:1990-11-30
    标 题:Solution phase process for synthesis of peptide
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    ✅ COA系统入驻 | 共享模式

    主要参考文献

    参考标题:Solid-Phase Synthesis Of C-Terminal Peptide Aldehydes From Amino Acetals Anchored To A Backbone Amide Linker (Bal) Handle
    作者:Fanny Guillaumie,Joseph C Kappel,Nicholas M Kelly,George Barany,Knud J Jensen |发布日期:2000.8
    摘要:Peptide Aldehydes Were Synthesized, Starting From Amino Acetals, By A Solid-Phase Backbone Amide Linker (Bal) Strategy.

    合成参考文献


    参考文献:10.1021/jm00027a027
    摘要:Ye QZ, Johnson LL, Nordan I, Hupe D, Hupe L. A recombinant human stromelysin catalytic domain identifying tryptophan derivatives as human stromelysin inhibitors. J Med Chem. 1994 Jan 07;37(1):206–9. doi: 10.1021/jm00027a027.
    参考文献:10.1007/s10529-005-0018-8
    摘要:Salam SM, Kagawa K, Kawashiro K. Alpha-chymotrypsin-catalyzed peptide synthesis using N-protected D-amino acid carbamoylmethyl esters as acyl donors. Biotechnol Lett. 2005 Aug;27(16):1199–203. doi: 10.1007/s10529-005-0018-8.
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