专利号:RU-2418798-C2 优先权日:2005-08-31 标 题 :Synthesis methods and intermediate compounds during synthesis of stereoisomeric compounds, suitable for treating gastrointestinal disorders and central nervous system disorders
专利号:US-4234744-A 优先权日:1978-12-18 标 题 :Process for the production of aminoacid hydrochlorides/or diaminoacid dihydrochlorides 发明人:EFFENBERGER FRANZ; DRAUZ KARLHEINZ 权利人:DEGUSSA 摘要:Aminoacid hydrochlorides or diaminoacid dihydrochlorides are produced by first reacting a halocarboxylic acid ester with an alkali metal cyanate in the presence of an alcohol to form the corresponding mono- or diurethane and then saponifying this to the corresponding mono- or dihydrochloride. The new process is relatively versatile in its use and above all opens up an elegant synthesis route for lysine.
专利号:US-4288453-A 优先权日:1977-10-07 标 题 :Derivatives of arylalkanoic acids, compositions and use 发明人:VINCENT MICHEL; DUHAULT JACQUES; BOULLANGER MICHELLE; REMOND GEORGES 权利人:SCIENCE UNION & CIE 摘要:There are now described some novel alpha-[1-aryl-2,2,2-trifluoroethoxy (or-ethylthio)]alkanoic acids that are useful for reducing triglycerides and cholesterol levels in the blood of animals. The percentage reduction in test rats has been observed to be from 20 to 65 for triglycerides and from 15 to 50 for cholesterol. A representative compound of the invention is alpha-(2,2,2-trifluoro-1-phenyl-1-ethoxy)butyric acid. Most of the compounds have an LD 50 greater than 800 mg/kg, intraperitoneally, in male mice. n A method of use, compositions, and a process for synthesis are also described.
专利号:KR-101351454-B1 优先权日:2005-08-31 标题:Methods and synthesis of stereoisomer compounds useful for the treatment of gastrointestinal and central nervous system disorders
专利号:CN-1858042-A 优先权日:2006-06-09 标 题:Synthesis of 2-butyl-3-(4-hydroxy-3,5-diiodobenzoyl)benzofuran
参考标题:Attempted Generation Of Azacyclopropenones A New Route To Nitriles 作者:A. Hassner,R.J. Isbister,R.B. Greenwald,J.T. Klug,E.C. Taylor |发布日期:1969.1 摘要:A Synthesis Of The Unknown Azacyclopropenone (Azirinone) System Was Attempted Via α-Azido Ketenes. Treatment Of α-Azido Acid Chlorides With Triethylamine, In An Attempt To Generate α-Azido Ketenes, Led In Good Yield To Nitriles Containing One Less Carbon. At −60° It Was Possible To Trap The α-Azido Ketene 7C With Benzalaniline To Form A β-Lactam. The Formation Of Nitriles Most Likely Proceeds By Intermediacy
合成参考文献
摘要:Gobec, S.; Urleb, U., Science of Synthesis, (2004) 16, 872. 摘要:Braverman, S.; Cherkinsky, M.; Birsa, M. L., Science of Synthesis, (2005) 18, 108. 摘要:Aitken, R. A.; Aitken, K. M., Science of Synthesis, (2010) 41, 29.