专利号:US-5827794-A 优先权日:1994-02-22 标 题 :Supported highly-polar liquid phase chiral sulfonated binap catalyst for asymmetric synthesis of optically active compounds 发明人:DAVIS MARK E; WAN KAM TO 权利人:CALIFORNIA INST OF TECHN 摘要:The present invention relates to water soluble chiral sulfonated 2,2'-bis(diphenylphosphino)-1,1'-binaphthyl and its use as organometallic catalysts for asymmetric synthesis of optically active compounds. Asymmetric reactions of the present invention include those reactions in which organometallic catalysts are commonly used. Such reactions include, but are not limited to, reduction and isomerization reactions on unsaturated substrates and carbon--carbon bond forming reactions. Examples of such reactions include, but are not limited to, hydrogenation, hydroboration, hydrosilylation, hydride reduction, hydroformylation, alkylation, allylic alkylation, arylation, alkenylation, epoxidation, hydrocyanation, disilylation, cyclization and isomerization reactions. n The catalysts of the present invention provide the advantage of functioning in the presence of water without loss in enantioselectivity relative to the nonsulfonated BINAP catalyst in an organic solvent. As a result, the catalysts of the present invention may be employed in water, water miscible solvents, in aqueous--organic two phase solvent systems and in supported aqueous phase catalysts in organic solvents without loss in enantioselectivity. Further, the catalysts of the present invention may also be effectively employed in highly polar solvents such as primary alcohols and ethylene glycol. n The present invention also relates to a method for conducting asymmetric reactions on prochiral unsaturated bonds contained within a compound using the water soluble chiral sulfonated 2,2'-bis(diphenylphosphino)-1,1'-binaphthyl organometallic catalysts of the present invention.
专利号:US-9982072-B2 优先权日:2013-10-30 标 题 :Synthesis of acetal compounds 发明人:LOCCUFIER JOHAN 权利人:AGFA GRAPHICS NV; AGFA NV 摘要:A process for the preparation of optionally asymmetric acetal compounds includes reacting a compound containing a hydroxyl group with a vinylether compound in the presence of a zwitterionic catalyst including at least one basic nitrogen containing structural fragment and at least one sulfonic acid group in its structure, with the proviso that a molar ratio of the basic nitrogen to sulfonic acid is 1:1.
专利号:US-5763624-A 优先权日:1995-06-08 标 题 :Process for the synthesis of 1-pyridiniumpropane-3-sulphonate 发明人:MINISCI FRANCESCO; FONTANA FRANCESCA; SERRI ANNA; BAIMA ROBERTO 权利人:GALVANEVET SPA 摘要:1-pyridiniumpropane-3-sulphonate is obtained by reacting 1-allylpyridinium chloride (3) and alkaline bisulfite, in an aqueous solution, in the presence of radical initiators, such as oxygen, hydrogen peroxide, peroxides, alkylhydroperoxides and alkaline or ammonium persulfates.
专利号:US-2409806-A 优先权日:1941-12-08 标 题:Synthesis of nicotinic compounds 发明人:WILLIAM SHIVE; GLENN RICHARD A 权利人:PITTSBURGH COKE & CHEMICAL CO
专利号:US-6004965-A 优先权日:1994-12-20 标题 :Sulfonamides 发明人:BREU VOLKER; BURRI KASPAR; CASSAL JEAN-MARIE; CLOZEL MARTINE; HIRTH GEORGES; LOEFFLER BERND-MICHAEL; MUELLER MARCEL; NEIDHART WERNER; RAMUZ HENRI 权利人:HOFFMANN LA ROCHE 摘要:Compounds of the formula: ##STR1## where A, B, R 1 -R 8 are as described herein are endothelin inhibitors that can be used in treating diseases associated with endothelin, such as high blood pressure. Chemical synthesis of these compounds and pharmaceutical compositions containing these compounds are also useful.
专利号:US-7511113-B2 优先权日:2002-04-26 标题:Oligomeric hydroxy arylether phthalonitiles and synthesis thereof 发明人:KELLER TEDDY M; DOMINGUEZ DAWN D 权利人:US NAVY 摘要:An aromatic ether oligomer or polyaromatic ether comprising the formula:n n O—Ar n ;n nwherein Ar is an independently selected divalent aromatic radical; formed by reacting a dihydroxyaromatic with a dihaloaromatic; and wherein the reaction is performed in the presence of a copper compound and cesium carbonate. The polyaromatic ether is formed when neither the dihydroxyaromatic nor the dihaloaromatic is present in an excess amount. The aromatic ether oligomer is formed by using an excess of either dihydroxyaromatic or dihaloaromatic. A phthalonitrile monomer comprising the formula:n n nformed by reacting a 3- or 4-nitrophthalonitrile with a hydroxy-terminated aromatic ether oligomer. A thermoset formed by curing the phthalonitrile monomer. Processes for forming all the above.
摘要:Schafer, E. W., Jr., W. A. Bowles Jr., and J. Hurlbut. 1983. The acute oral toxicity and repellency and hazard potential of 998 chemicals to one or more species of wild and domestic birds. Archives of Environmental Contamination and Toxicology 12:355-382. 摘要:Schafer, E.W., Jr., et al. 1982. Effects of 77 chemicals on reproduction in male and female coturnix quail. Ecotox. Environ. Safety 6:149-156 摘要:R.F. Evans and H.C. Brown. J. Org. Chem. 27, 3127 (1962). 摘要:Kleemann A., Kutscher B., Reichert D., Bossart M., Pharmaceutical Substances, Thieme [Online], Stuttgart, (2025). 参考文献:10.1107/s1600536810029119 摘要:Nirmalram JS, Thomas Muthiah P. Hydrogen-bonding patterns in pyrimethaminium pyridine-3-sulfonate. Acta Crystallogr Sect E Struct Rep Online. 2010 Jul 24;66(Pt 8):o2121–2.