CAS: 68837-59-2; 4-Bromo-2-Methylbenzoic Acid

上下游产品

CAS号67832-11-5 4-溴-2-甲基苯甲腈 | CAS号106-44-5 对甲酚 | CAS号583-75-5 4-溴-2-甲基苯胺 | CAS号10087-24-8 4-methyl-4-trib... | CAS号109-72-8 正丁基锂 | CAS号615-59-8 2,5-二溴甲苯 | CAS号583-71-1 3,4-二甲基溴苯 | CAS号7697-37-2 硝酸 | CAS号220389-34-4 4-溴-2-甲基苯甲酸乙酯 | CAS号1975-53-7 4-氰基-2-甲基苯甲酸 | CAS号215800-05-8 2-(4-溴-2-甲氧基苯基)乙腈 | CAS号21900-45-8 4-溴-2-甲基苯甲酰氯 | CAS号24078-12-4 4-溴-2-甲基苯甲醛 | CAS号99548-55-7 4-溴-2-甲基苯甲酸甲酯 | CAS号868066-91-5 5-溴-2-甲基异二氢吲哚-1-酮 | CAS号86-90-8 4-溴邻苯二甲酸酐 | CAS号64169-34-2 5-溴苯酞 | CAS号6968-28-1 4-溴邻苯二甲酸

4-溴-2-甲基苯腈置于potassium Hydroxide体系中,用 水 作为反应溶剂,以60%的收率获得产物4-溴-2-甲基苯甲酸
参考文献:发现和开发新型水杨酸合酶(mbti)呋喃类抑制剂作为抗结核药
标题:发现和开发新型水杨酸合酶(mbti)呋喃类抑制剂作为抗结核药
摘要:我们报告针对结核分枝杆菌水杨酸合酶(mbti)的新呋喃衍生物的虚拟筛选,合成和生物学评估.应用基于受体的虚拟筛选程序筛选enamine数据库,鉴定出具有非常好酶抑制活性的两种化合物i和iii.考虑到最具活性的化合物i作为开发新型mbti抑制剂的起点,我们获得了基于呋喃支架的新衍生物.在此类sar中,化合物1A成为迄今为止报道的最有效的mbti抑制剂(k I = 5.3μm).此外,化合物1A表现出有希望的抗 分枝杆菌活性(mic 99 = 156μm),这可能与分枝杆菌素的生物合成抑制有关.
DOI:10.1016/j.Ejmech.2018.06.033

专利信息

专利号:WO-2021249877-A1
优先权日:2020-06-08
标 题 :Intermediates and processes for the preparation of tolvaptan and its derivatives
发明人：VIGO DANIELE; CAPUTO FRANCESCO; COLOMBO FRANCESCO
权利人:CAMBREX PROFARMACO MILANO S R L
摘要:The present invention relates to new intermediates for the synthesis of Tolvaptan and of its derivatives and a process for its preparation involving said intermediates.

专利号:US-2024400552-A1
优先权日:2016-11-11
标题 :Heterocyclic modulators of lipid synthesis
发明人：BUCKLEY DOUGLAS I; DUKE GREGORY; WAGMAN ALLAN S; EVANCHIK MARC; MCDOWELL ROBERT S
权利人:SAGIMET BIOSCIENCES INC
摘要:Compounds that are fatty acid synthesis modulators are provided. The compounds may be used to treat disorders characterized by dysregulation of the fatty acid synthase function by modulating the function and/or the fatty acid synthase pathway. Methods are provided for treating such disorders including viral infections, such as hepatitis C infection, cancer and metabolic disorders, such as non-alcoholic steatohepatitis (NASH).

专利号:US-11622968-B2
优先权日:2011-03-08
标 题:Heterocyclic modulators of lipid synthesis
发明人：BUCKLEY DOUGLAS; DUKE GREGORY; WAGMAN ALLAN S; EVANCHIK MARC; MCDOWELL ROBERT S
权利人:SAGIMET BIOSCIENCES INC
摘要:Compounds that are fatty acid synthesis modulators are provided. The compounds may be used to treat disorders characterized by disregulation of the fatty acid synthase function by modulating the function and/or the fatty acid synthase pathway. Methods are provided for treating such disorders including viral infections, such as hepatitis C infection, cancer and metabolic disorders, such as non-alcoholic steatohepatitis (NASH).

专利号:US-10226449-B2
优先权日:2013-12-20
标 题:Heterocyclic modulators of lipid synthesis and combinations thereof
发明人：HEUER TIMOTHY SEAN; OSLOB JOHAN D; MCDOWELL ROBERT S; JOHNSON RUSSELL; YANG HANBIAO; EVANCHIK MARC; ZAHARIA CRISTIANA A; CAI HAIYING; HU LILY W; DUKE GREGORY; OHOL-GUPTA YAMINI; O'FARRELL MARIE
权利人:3 V BIOSCIENCES INC
摘要:Heterocyclic modulators of lipid synthesis are provided as well as pharmaceutically acceptable salts thereof; pharmaceutical compositions comprising such compounds; and methods of treating conditions characterized by dysregulation of a fatty acid synthase pathway by the administration of such compounds and combinations of such compounds and other therapeutic agents.

专利号:US-11034690-B2
优先权日:2016-11-11
标 题:Heterocyclic modulators of lipid synthesis
发明人：BUCKLEY DOUGLAS I; DUKE GREGORY; WAGMAN ALLAN S; EVANCHIK MARC; MCDOWELL ROBERT S
权利人:SAGIMET BIOSCIENCES INC; SAGINIET BIOSCIENCES INC
摘要:Compounds that are fatty acid synthesis modulators are provided. The compounds may be used to treat disorders characterized by disregulation of the fatty acid synthase function by modulating the function and/or the fatty acid synthase pathway. Methods are provided for treating such disorders including viral infections, such as hepatitis C infection, cancer and metabolic disorders, such as non-alcoholic steatohepatitis (NASH).

专利号:US-9428502-B2
优先权日:2012-07-03
标题:Heterocyclic modulators of lipid synthesis
发明人：OSLOB JOHAN D; MCDOWELL ROBERT S; JOHNSON RUSSELL; YANG HANBIAO; EVANCHIK MARC; ZAHARIA CRISTIANA A; CAI HAIYING; HU LILY W; WAGMAN ALLAN S
权利人:3-V BIOSCIENCES INC
摘要:Heterocyclic modulators of lipid synthesis are provided as well as pharmaceutically acceptable salts thereof; pharmaceutical compositions comprising such compounds; and methods of treating conditions characterized by disregulation of a fatty acid synthase pathway by the administration of such compounds.