CAS: 80-35-3; 4-Amino-N-(6-Methoxypyridazin-3-yl)Benzenesulfonamide

该化合物是一种合成抗微生物剂,其抗微生物剂具有广泛的抗克阴性细菌活动特征,通过迅速抑制细菌生长和复制,对哺乳动物细胞代谢作用最小,为治疗细菌感染提供了有效解决办法,其独特的药代基因特征使得能够有针对性地交付.

结构式图片

欧盟法规

ECHA物质ECHA物质C&L通报REACH预注册

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CAS号127-75-3 4'-(6-methoxypy... | CAS号80-32-0 磺胺氯哒嗪 | CAS号124-41-4 甲醇钠 | CAS号127-75-3 4'-(6-methoxypy... | CAS号3568-43-2 N-(4-aminopheny...

合成工艺路线路线简述

  • 合成目标产物 Sulfamethoxypyridazine 主要起始原料 3-Amino-6-Methoxypyridazine And N-Acetylsulfanilyl Chloride
  • (文献来源)合成步骤主要原料 3-Amino-6-Methoxypyridazine 和 N-Acetylsulfanilyl Chloride
N-[4-[(6-甲氧基哒嗪-3-基)氨基磺酰基]苯基]乙酰胺置于sodium Hydroxide体系中,化学反应生成 磺胺甲氧哒嗪
参考文献:3-Sulfanilamido-6-Alkoxypyridazines And Related Compounds
标题:3-Sulfanilamido-6-Alkoxypyridazines And Related Compounds
摘要:
DOI:10.1021/ja01537A060

海关参考信息

专利信息


专利号:US-2008096242-A1
优先权日:2004-09-01
标 题 :Enhanced Substrate Conversion Efficiency Of Fermentation Processes
发明人:SANDERS JOHAN P M; WEUSTHUIS RUUD A; MOOIBROEK ANDREAS
权利人:AGROTECHNOLOGY AND FOOD INNOVA
摘要:The present invention relates to the field of fermentation technology. In particular the invention relates to fermentation processes for the production of a first and a second fermentation product by a single production organism wherein the first product is in a more reduced state than the substrate and the second fermentation product is in a more oxidised state than the substrate yet in a less oxidised state than the final oxidation product CO 2 , such that the concurrent synthesis of the first and second product in the organism allows recycling of reducing power and can be performed under (partially) anaerobic conditions. The invention also relates to such processes in which the first and second fermentation products are capable of forming a(n) (insoluble) complex or salt.

专利号:US-9439423-B2
优先权日:2007-10-29
标 题 :Antiparasitic agent for fish and method of controlling proliferation of fish parasites
发明人:KAWANO FUMI; HIRAZAWA NORITAKA
权利人:KAWANO FUMI; HIRAZAWA NORITAKA; NIPPON SUISAN KAISHA LTD
摘要:An antiparasitic agent for fish includes an inhibitor of folate synthesis and/or an inhibitor of folate activation as the active substance(s). A combination preparation composed of an inhibitor of folate synthesis and an inhibitor of folate activation is disclosed. Sulfonamide is disclosed as suitable for the inhibitor of folate synthesis. A dihydrofolate reductase inhibitor, a folate antagonist are disclosed as suitable inhibitors of folate activation. The antiparasitic agent is able to exterminate fish parasites via oral administration. It is effective against fish parasites belonging to the ciliate group.

专利号:US-9265777-B2
优先权日:2009-04-27
标题 :Antiparasitic agent for fish and method of controlling proliferation of fish parasites
发明人:KAWANO FUMI; HIRAZAWA NORITAKA
权利人:KAWANO FUMI; HIRAZAWA NORITAKA; NIPPON SUISAN KAISHA LTD
摘要:A method of controlling proliferation of fish parasites comprising the administration of 1 to 50 mg/kg fish body weight/day of an inhibitor of folate synthesis and/or an inhibitor of folate activation to fish continuously for 1 to 2 weeks. Using a combination preparation composed of an inhibitor of folate synthesis and an inhibitor of folate activation is preferable, and a sulfonamide is preferable for the inhibitor of folate synthesis. A dihydrofolate reductase inhibitor, a folate antagonist, etc., can be used as the inhibitor of folate activation. The antiparasitic agent is able to exterminate fish parasites via oral administration. It is particularly effective against parasites belonging to the ciliate group among fish parasites.

专利号:US-6103865-A
优先权日:1998-08-03
标 题 :PH-sensitive polymer containing sulfonamide and its synthesis method
发明人:BAE YOU HAN; PARK SANG YEOB
权利人:KWANGJU INST SCI & TECH
摘要:There are disclosed pH-sensitive polymers containing sulfonamide groups, which can be changed in physical properties, such as swellability and solubility, depending on pH and which can be applied for a drug-delivery system, bio-material, sensor, etc, and a preparation method therefor. The pH-sensitive polymers are prepared by introduction of sulfonamide groups, various in pKa, to hydrophilic groups of polymers either through coupling to the hydrophilic groups, such as acrylamide, N,N-dimethylacrylamide, acrylic acid, N-isopropylacrylamide, etc, of polymers or copolymerization with other polymerizable monomers. These pH-sensitive polymers may have a structure of linear polymer, grafted copolymer, hydrogel or interpenetrating network polymer.

专利号:US-2007021349-A1
优先权日:2005-04-28
标题:Orthogonally protected bifunctional amino acid
发明人:SRINIVASAN ANANTH; LUYT LEONARD G
权利人:SRINIVASAN ANANTH; LUYT LEONARD G
摘要:The present invention concerns novel orthogonally protected amino acids, there production and use for the synthesis of binding compounds usable in the diagnosis and treatment of proliferative diseases, in particular tumor diseases.

专利号:US-2025064840-A1
优先权日:2021-12-16
标 题 :Drug delivery systems based on endoperoxides useful in diagnosis and therapy, and methods thereof
发明人:SILVA MAGALHAES DIOGO; MOREIRA RUI; LOPES FRANCISCA; RODRIGUES CECILIA; MARQUES VANDA
权利人:FACULDADE DE FARMACIA DA UNIV DE LISBOA
摘要:The present invention relates to novel drug delivery systems based on endoperoxide moieties such as 1,2,4,5-tetraoxanes, namely compounds of formula I, appropriately modified to release active pharmaceutical ingredients (API) in the presence of higher levels of Fe (II), in a subject, whereinIron metabolism dysregulation occurs in diseases such as malaria and cancer. Therefore, the present invention also relates to biomarkers comprising said compounds of formula I.Another aspect, the present invention relates to a process of synthesis of compounds of formula I and respective intermediaries.Further, the present invention also relates to a process for labelling, detection, and identification of tumours in a tissue sample.The present invention is thus applicable to the medical and pharmacological areas, in related to particular the ones cancer detection and treatment, and malaria treatment.
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主要参考文献


1: Rajendiran N, Venkatesh G, Mohandass T. Fabrication of 2D nanosheet through self assembly behavior of sulfamethoxypyridazine inclusion complexes with α- and β-cyclodextrins. Spectrochim Acta A Mol Biomol Spectrosc. 2014 Apr 5;123:158-66. doi: 10.1016/j.saa.2013.12.053. Epub 2013 Dec 18. doi: 10.1016/j.jhazmat.2012.10.059. Epub 2012 Nov 3. Russian. doi: 10.1021/jf904338f. French.
9: RYSSING E. [Protracted antibacterial prophylaxis with sulfamethoxypyridazine (Lederkyn) in children with asthma]. Ugeskr Laeger. 1959 Nov 12;121:1768-70. Danish. Review. Czech. Epub 2007 Jul 28. French. Italian.

合成参考文献


摘要:Arzneimittel-Forschung. Drug Research., 10(612), 1960 []
摘要:S72 | NTUPHTW | Pharmaceutically Active Substances from National Taiwan University | DOI:10.5281/zenodo.3955664
摘要:SHETH UK, KULKARNI BS, KAMATH PG. Sulfamethoxypyridazine, a new long-acting sulfonamide; a study of blood levels in adults with different dose schedules. Antibiotic Med Clin Ther (New York). 1958 Oct;5(10):604–8.
摘要:BLANCHARD AJ, MERTENS GA. Hypersensitivity myocarditis occurring with sulfamethoxypyridazine therapy. Can Med Assoc J. 1958 Oct 15;79(8):627–30.
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