CAS: 1302-78-9; Bentonite

专利信息

专利号:US-12221452-B2
优先权日:2017-10-04
标题:Synthesis of cantharidin
发明人：DAVIDSON MATTHEW GENE; EKLOV BRIAN MATTHEW; WUTS PETER; LOERTSCHER BRAD MELVIN; SCHOW STEVEN R
权利人:VERRICA PHARMACEUTICALS INC
摘要:The invention provides synthetic methods for the preparation of cantharidin and analogs thereof. In one aspect, the invention provides an improved Diels-Alder cycloaddition to generate a key intermediate en route to cantharidin and analogs thereof. In certain embodiments, the new Diels-Alder reaction involves reacting Compound (2) in the presence of furan, and in the absence of acid or increased pressure, in an aprotic polar solvent with slight warming, to yield Compound (1) in favorable yield and exo-endo ratio. In another aspect, the invention also provides a new Diels-Alder reaction between compounds of Formula (III) and furan to yield compounds of Formula (IV), which can then be transformed into cantharidin or analogs thereof. In yet another aspect, the invention describes a new palladium-mediated carbonylation providing another key intermediate en route to cantharidin and analogs thereof. In addition to synthetic methods, present invention also provides compounds (i.e., intermediates) useful in the synthesis of cantharidin and analogs thereof. Compounds provided herein may have biological activity, and therefore may be used in the treatment of diseases or conditions (e.g., infectious diseases and skin conditions).

专利号:WO-2004089946-A1
优先权日:2003-04-07
标题:Microwave synthesis of mycophenolate
发明人：ADHIKARY LAXMI; SURYANARAYAN SHRIKUMAR
权利人:BIOCON LTD; ADHIKARY LAXMI; SURYANARAYAN SHRIKUMAR
摘要:A process for synthesis of a compound of formula (I) using microwave irradiation.

专利号:US-11738092-B2
优先权日:2019-12-04
标题:Methods and compositions for synthesis of therapeutic nanoparticles
发明人：WYENT EMILY A; BLUMENFELD CARL M; LAMM ROBERT J
权利人:DANTARI INC
摘要:Improved methods and reactants for the chemical synthesis of therapeutic nanoparticles are provided. The nanoparticles comprise a polymeric core, to which is attached one or more homing molecules and one or more therapeutic agents. Improvements in speed, yield and purity are attained using the methods disclosed herein.

专利号:US-5780689-A
优先权日:1991-07-10
标题 :Superacidic catalysts for the synthesis of methyl-tert-butyl ether (MTBE)
发明人：MAO RAYMOND LE VAN
权利人:QUEBECOISE D INITIATIVES PETRO
摘要:In accordance with the present invention, there is now provided a novel selective catalyst useful for the synthesis of methyl-tert-butyl ether (MTBE) or ethyl-tert-butyl ether (ETBE) prepared by reacting isobutene with methanol or ethanol, respectively. More specifically, the catalyst of the present invention comprises from about 0.5 to about 7% by weight of triflic acid (trifluoro-methanesulfonic acid, CF3SO3H, hereafter referred to as TFA) incorporated onto an acid form Y zeolite.

专利号:WO-9522512-A1
优先权日:1994-02-16
标题:Method for joining ceramic and metal-ceramic heating elements to electrical terminals by micropyretic synthesis, compositions for electrical terminals and heaters comprising the same
发明人：SEKHAR JAINAGESH A; ZHU NAIPING
权利人:UNIV CINCINNATI
摘要:A method for joining a ceramic or metal ceramic electrical heating element (1) to an electrical terminal (2) is disclosed, the heating element having been manufactured using micropyretic synthesis, the method for joining comprising the steps of preparing the electrical terminal by blending a combustible mixture and fashioning the mixture into a desired wet and uncombusted shape for the terminal, attaching the terminal to the element, drying the terminal portion of the terminal-element attachment and combusting the terminal portion of said terminal-element attachment by ignition at a temperature between about 150 °C and 1800 °C. An electrical terminal is disclosed, the terminal having been formed by micropyretic synthesis of a specific combustible composition. A heating element assembly for a heater is disclosed comprising a first and a second ceramic or metal ceramic electrical terminals, a plurality of ceramic or metal ceramic heating elements and a plurality of ceramic or metal ceramic coolers (3) which are used to connect said plurality of heating elements to each other.

专利号:US-11634334-B2
优先权日:2019-09-30
标题:Method of synthesizing an aluminosilicate molecular sieve by a crystal seed-assisted method
发明人：ZHENG TAO; LIU HAIYAN; LIU ZHICHANG; MENG XIANGHAI; ZHANG RUI; XU CHUNMING
权利人:UNIV CHINA PETROLEUM BEIJING
摘要:The present disclosure provides a method of synthesizing an aluminosilicate molecular sieve by a crystal seed-assisted method, a natural aluminosilicate clay mineral treated and activated by an alkali is used as a crystal seed for synthesis of the aluminosilicate molecular sieve, and the target molecular sieve product is synthesized by hydrothermal crystallization, wherein the synthesis process does not require addition of conventional crystal seeds of a molecular sieve or use of any organic template agent, thus the synthesized product does not require a calcination process to remove the template agent. The method of synthesizing an aluminosilicate molecular sieve by a crystal seed-assisted method can meet the requirements of both crystallinity and nucleation time, and greatly reduce costs of synthesizing the aluminosilicate molecular sieve, and reduce the environmental pollution caused by removal of the template agent by calcinating.