CAS: 13734-28-6; (S)-6-Amino-2-((Tert-Butoxycarbonyl)Amino)Hexanoic Acid

相似化合物

10009-20-8 105047-45-8 106719-44-2

上下游产品

N-(tert-butyloxycarbonyl) azide 6-[(benzyloxy)carbonyl]-L-lysineN6-[(benzyloxy)carbonyl]-L-lysine B°C-Lys(Z)-OH α-tert-butoxycarbonyl-Nε-tosyl-L-lysineNα-tert-butoxycarbonyl-Nε-tosyl-L-lysine(S)-6-trifluoroacetylamino-2-(tert-butoxycarbonylamino)-hexanoic acid 2-[(1,1-dimethylethoxy)carbonyl]-N6-{[2-(methylsulfonyl)ethoxy]carbonyl}-L-lysineN2-[(1,1-dimethylethoxy)carbonyl]-N6-{[2-(methylsulfonyl)ethoxy]carbonyl}-L-lysine B°C-Lys(biotinyl)-OH 6-benzoylamino-2-tert-butoxycarbonylamino-hexanoic acid

Boc-L-Lys-Ogp置于bacillus Cereus Recombinant His-Tagged Alkaline D-Peptidase,水,4-羟乙基哌嗪乙磺酸体系中,用 N,N-二甲基甲酰胺 用作溶剂,化学反应生成N-Alpha-叔丁氧羰基-L-赖氨酸
参考文献:D氨基酸特异性蛋白酶和天然全l蛋白:半合成的便捷组合.
标题:D氨基酸特异性蛋白酶和天然全l蛋白:半合成的便捷组合.
摘要:
Doi:10.1002/anie.200800340

专利信息

专利号:US-6451543-B1
优先权日:1998-08-31
标题:Lipid matrix-assisted chemical ligation and synthesis of membrane polypeptides
发明人：KOCHENDOERFER GERD G; HUNTER CHRISTIE L; KENT STEPHEN B H; BOTTI PAOLO
权利人:GRYPHON SCIENCES
摘要:The present invention relates to methods and compositions for lipid matrix-assisted chemical ligation and synthesis of membrane polypeptides that are incorporated in a lipid matrix. The invention is exemplified in production of a prefolded membrane polypeptide embedded within a lipid matrix via stepwise chemoselective chemical ligation of unprotected peptide segments, where at least one peptide segment is embedded in a lipid matrix. Any chemoselective reaction chemistry amenable for ligation of unprotected peptide segments can be employed. Suitable lipid matrices include liposomes, micelles, cell membrane patches and optically isotropic cubic lipidic phase matrices. Prefolded synthetic and semi-synthetic membrane polypeptides synthesized according to the methods and compositions of the invention also permit site-specific incorporation of one or more detectable moieties, such as a chromophore, which can be conveniently introduced during synthesis. The methods and compositions of the invention have multiple uses. For example, they can be used to assay ligand binding to membrane polypeptides and domains comprising a receptor, and thus are extremely useful for structure/function studies, drug screening/selection/design, and diagnostics and the like, including high-throughput applications. The methods and compositions of the invention are particularly suited for FRET analyses of previously inaccessible membrane polypeptides.

专利号:WO-2025075817-A1
优先权日:2023-10-02
标 题 :Methods for synthesis of protein hetero-polymers
发明人：SHRADER ALANNA SCHEPARTZ; ROE LEAH TANG
权利人:UNIV CALIFORNIA
摘要:A method for synthesis of protein hetero-polymers uses an intramolecular Backbone Extension Acyl Rearrangement (BEAR) reactions to orthogonally and site-specifically embed a β-, γ- or δ-amino acid residue into proteins.

专利号:US-6849710-B1
优先权日:1996-07-30
标 题:Method for the synthesis of analogs of parathyroid hormone and parathyroid hormone related peptide
发明人：ARZENO HUMBERTO
权利人:HOFFMANN LA ROCHE
摘要:A fragment condensation process for the synthesis of analogs of parathyroid hormone (PTH) and parathyroid hormone related peptide (PTHrP), in which amino acid residues (22-31) form a synthetic amphipathic α-helix, is provided.

专利号:US-4504415-A
优先权日:1983-04-04
标题:Synthesis of thymosin α1 and desacetyl thymosin α1
发明人：FELIX ARTHUR M; GILLESSEN DIETER; STUDER ROLF; MEIENHOFER JOHANNES A; TRZECIAK ARNOLD
权利人:HOFFMANN LA ROCHE
摘要:An improved solution phase synthesis of thymosin alpha 1 and desacetyl thymosin alpha 1 with t-Boc side chain protection and proceeding through novel intermediates is disclosed.

专利号:US-4517119-A
优先权日:1983-04-04
标题:Synthesis of thymosin α1
发明人：FELIX ARTHUR M; GILLESSEN DIETER; LERGIER WILLIAM; MEIENHOFER JOHANNES A; TRZECIAK ARNOLD
权利人:HOFFMANN LA ROCHE
摘要:An improved solution phase synthesis of thymosin α 1 and proceeding through novel intermediates is disclosed.

专利号:US-2004110228-A1
优先权日:2002-04-01
标 题:Combinatorial organic synthesis of unique biologically active compounds
发明人：MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.