CAS: 26328-04-1; 1-(4-(2-Oxo-2-(Pyrrolidin-1-yl)Ethyl)Piperazin-1-yl)-3-(3,4,5-Trimethoxyphenyl)Prop-2-En-1-One Maleate

专利信息

专利号:US-8354116-B2
优先权日:2007-06-18
标题 :Bifunctional synthetic molecules
发明人：CARTER STEPHEN G; PATEL KANU; ZHU ZHEN; QIAO LIXIN
权利人:BIOCHEMICS INC; CARTER STEPHEN G; PATEL KANU; ZHU ZHEN; QIAO LIXIN
摘要:The synthesis and use of bifunctional molecules to improve the topical and transdermal delivery efficiency of various types of therapeutic agents or agents designed to promote the transdermal delivery of those therapeutic agents either into the skin tissue or into the systemic circulation. Three major classes of molecules are covalently joined as bifunctional substances; chemical vasodilators, passive dermal penetration enhancers and therapeutic or diagnostic drugs. Chemical vasodilators may be delivered into the skin to increasing the blood flow in a tissue that has compromised circulation or they may be used as part of a delivery vehicle to promote the delivery of the drug. Passive dermal penetration enhancers are those chemicals that promote the passive penetration of drugs and other chemicals through the stratum corneum and epidermis of the skin tissue. Drugs and diagnostic agents are the third group of chemicals that are candidates for the linkage of molecules.

专利号:US-6884842-B2
优先权日:1997-10-14
标题:Molecular compounds having complementary surfaces to targets
发明人：SOANE DAVID S; BARRY STEPHEN E; GOODWIN ANDREW; OFFORD DAVID A; PERROTT MICHAEL G
权利人:ALNIS BIOSCIENCES INC
摘要:Synthetic polymer complements (SPCs) are provided, as well as methods for their synthesis and use. The SPCs may have surfaces that include functional groups that are complementary to surface sites of targets such as nanostructures or macromolecular targets, and may be capable of specifically interacting with such targets. The positions of the functional groups in one embodiment are stabilized by a polymer network. The SPCs are formed by contacting the target with a set of monomers which self-assemble on the target, and then are polymerized into a network to form the synthetic polymer complement. At least a portion of the surface of the resulting SPC thus may include an imprint of the target. The complex of the SPC and the target may be the desired product. Alternatively, the target is released, for example, by controllably expanding and contracting the crosslinked network. The SPC is isolated and used in many applications.

专利号:CN-1631877-A
优先权日:2004-11-22
标 题 :Synthesis method of cinepazide maleate