CAS: 329187-59-9; 4-((4,6-Dichloropyrimidin-2-yl)Amino)Benzonitrile

相似化合物

244768-32-9 1398507-08-8 950752-52-0

上下游产品

4-((4,6-dihydroxypyrimidine-2-yl)amino)benzonitrile 4-cyanophenyl guanidine hydr°Chloride 4-Aminobenzonitrile 1-(4-cyanophenyl)guanidine4-[[(5-bromo-4,6-dichloro)-2-pyrimidinyl]amino]benzonitrile 20H15ClN6C20H15ClN6 22H17ClN6C22H17ClN6 4-[[6-chloro-2-[(4-cyanophenyl)amino]-4-pyrimidinyl]oxy]-3,5-dimethyl-benzonitrile

N-(4-氰基苯基)胍置于乙醇,Sodium,N,N-二甲基苯胺,三氯氧磷体系中,化学反应 18.0H,反应生成 4-N[2(4,6-二氯吡啶基)]-氨基苯腈
参考文献: A Process For Etra Virine Intermediate And Polymorphs Of Etravirine[fr] Procédé De Préparation D'Intermédiaire De L'étravirine Et De Polymorphes De L'étravirine
标题: A Process For Etra Virine Intermediate And Polymorphs Of Etravirine[fr] Procédé De Préparation D'Intermédiaire De L'étravirine Et De Polymorphes De L'étravirine
摘要:4-[[6-氯-2-[(4-氰基苯基)氨基]-4-嘧啶基]氧基]-3,5-二甲基苯甲腈是埃替韦林的制备的关键中间体.本发明提供了一种制备4-[[6-氯-2-[(4-氰基苯基)氨基]-4-嘧啶基]氧基]-3,5-二甲基苯甲腈的方法.本发明还提供了一种制备埃替韦林晶型i的新方法.本发明还提供了埃替韦林的新晶型,以及它们的制备方法和包含它们的药物组合物.

专利信息

专利号:US-2015336900-A1
优先权日:2012-10-29
标题 :Process for the Synthesis of Etravirine and Its Intermediates
发明人：PULLAGURLA MANIK REDDY; RANGISETTY JAGADEESH BABU; NANDAKUMAR MECHERIL VALSAN
权利人:BIOPHORE INDIA PHARMACEUTICALS PVT LTD
摘要:The invention discloses the synthesis of Etravirine via intermediate 4-((4-amino-5-bromo-6-chloropyrimidin-2-yl) amino)benzonitrile and process for the preparation of Etravirine of the formula-I.

专利号:US-2011196156-A1
优先权日:2009-06-22
标 题 :Process for synthesis of diarylpyrimidine non-nucleoside reverse transcriptase inhibitor

专利号:WO-2010150279-A2
优先权日:2009-06-22
标 题 :Process for synthesis of diarylpyrimidine non-nucleoside reverse transcriptase inhibitor

专利号:WO-2014068588-A2
优先权日:2012-10-29
标题:Process for the synthesis of etravirine and its intermediates