CAS: 399-94-0; 1-Bromo-2,5-Difluorobenzene

上下游产品

CAS号540-36-3 1,4-二氟苯 | CAS号198967-26-9 2,5-difluoro-N-... | CAS号28736-42-7 1,4-二氟蒽醌 | CAS号112898-33-6 反式-2,5-二氟肉桂酸 | CAS号167415-27-2 1-溴-2,5-二氟-4-硝基苯 | CAS号2991-28-8 2,5-二氟苯甲酸 | CAS号123942-11-0 1-(4-溴-2,5-二氟苯基)乙酮 | CAS号1218935-59-1 (R)-2-(2,5-二氟苯基)吡咯烷

1,4-二氟苯置于n-溴代丁二酰亚胺(Nbs),硫酸体系中,化学反应 1.0H,以92.7%的收率获得2,5-二氟溴苯
参考文献:一种2,5-二氟-4-硝基苯甲酸的制备方法
标题:一种2,5-二氟-4-硝基苯甲酸的制备方法
摘要:本发明公开了一种2,5‑二氟‑4‑硝基苯甲酸的工业化制备方法.该2,5‑二氟‑4‑硝基苯甲酸的工业化制备方法,以对二氟苯为初始原料,经过溴代,硝化,氰化,水解四步反应合成2,5‑二氟‑4‑硝基苯甲酸.本过程得到的2,5‑二氟‑4‑硝基苯甲酸为白色粉末状固体,纯度98.5%,每步原料转化率分别达到100%,整个过程的总收率达到44.6%.

专利信息

专利号:US-9481680-B2
优先权日:2014-03-20
标题 :Process for the preparation of key intermediates of omarigliptin
发明人：DE LUCCHI OTTORINO; ROSSO ENRICO; ZARAMELLA SIMONE; TARTAGGIA STEFANO
权利人:F I S —FABBRICA ITALIANA SINTETICI S P A; F I S —FABBRICA ITALIANA SINTETICI S P A
摘要:An improved process for the preparation of a key intermediate for the synthesis of the active ingredient Omarigliptin is provided. The key intermediate is a compound having the following formula (I) n nwherein R 1 is propargyl or allyl group and P is an amine protecting group. The compound of formula (I) is prepared by converting a compound of formula (IV)n n nby an amination reaction to a compound of formula (III),n n nwhich is then protected to provide a compound of formula (II),n n nwhich is then alkylated to provide the compound of formula (I).

专利号:US-7411088-B2
优先权日:2004-02-20
标 题:Stereoselective synthesis of a 4,4-disubstituted cyclohexanepropanoic acid
发明人：BRANDS KAREL MARIE JOSEPH; BREWER SARAH ELIZABETH; DAVIES ANTONY JOHN; DOLLING ULF H; HAMMOND DEBORAH CAMILLE; LIEBERMAN DAVID ROSS; SCOTT JEREMY PETER
权利人:MERCK & CO INC; MERCK SHARP & DOHME
摘要:There is provided stereoselective route to a compound of formula I: n nwherein R represents H or an alkali metal, Ar 1 represents 4-chlorophenyl and Ar 2 represents 2,5-difluorophenyl.

专利号:US-9676783-B2
优先权日:2008-10-22
标 题:Method of treatment using substituted pyrazolo[1,5-A] pyrimidine compounds
发明人：HAAS JULIA; ANDREWS STEVEN W; JIANG YUTONG; ZHANG GAN
权利人:ARRAY BIOPHARMA INC
摘要:Compounds useful in the synthesis of compounds for treating pain, cancer, inflammation, neurodegenerative disease or Typanosoma cruzi infection in a mammal.

专利号:US-7205300-B2
优先权日:1997-12-31
标 题:Aryl fused azapolycyclic compounds
发明人：COE JOTHAM WADSWORTH; BROOKS PAIGE ROANNE PALMER
权利人:PFIZER
摘要:This invention is directed to compounds of the formula (I): n nand their pharmaceutically acceptable salts, wherein R 1 , R 2 , and R 3 are as defined herein; intermediates for the synthesis of such compounds, pharmaceutical compositions containing such compounds; and methods of using such compounds in the treatment of neurological and psychological disorders.

专利号:US-2007225520-A1
优先权日:2004-02-20
标题 :Stereoselective Synthesis of a 4,4-Disubstituted Cyclohexanepropanoic Acid

专利号:CA-2556348-A1
优先权日:2004-02-20
标 题 :Stereoselective synthesis of a 4,4-disubstituted cyclohexanepropanoic acid