CAS: 486-25-9; 9H-Fluoren-9-One

上下游产品

CAS号112305-77-8 9-[ethoxy(pheny... | CAS号1689-64-1 9-芴醇 | CAS号3073-51-6 9-(9-hydroxyflu... | CAS号111410-41-4 9-(9,10-dihydro... | CAS号109685-01-0 9-cyclopropa[b]... | CAS号286-85-1 2,3-Methanonaph... | CAS号1072315-89-9 9-甲基-9 H -芴-9-羰... | CAS号467-69-6 9-羟基-9-芴甲酸 | CAS号1989-33-9 9-芴甲酸 | CAS号86-73-7 芴

邻溴三氟甲苯置于四(三苯基膦)钯,Alumina,Potassium Carbonate体系中,用 甲醇,甲苯 作为反应溶剂,化学反应 12.0H,反应生成 9-芴酮
参考文献:Aluminum Oxide Mediated C-f Bond Activation In Trifluoromethylated Arenes
标题:Aluminum Oxide Mediated C-f Bond Activation In Trifluoromethylated Arenes
摘要:热活化的γ-氧化铝被发现在三氟甲基芳烃中对c-F键的活化非常有效.
DOI:10.1039/c5Cc08747C

专利信息

专利号:US-2024409495-A1
优先权日:2021-10-20
标 题 :Process for the preparation of 2,7-dihydroxy-9-fluorenone useful for the synthesis of tilorone and its salts
发明人：JAISANKAR PARASURAMAN; DEB INDUBHUSAN; BHATTACHARJEE PINAKI
权利人:COUNCIL SCIENT IND RES
摘要:Methods involving preparation of building blocks of 2,7-dihydroxy-9-fluorenone toward the synthesis of tilorone dihydrochloride salt and other salts (bromide, iodide, fluoride, citrate, oxalate, maleate, phosphate, tartrate, triflate, trifluoroacetate, tetrafluoroborate) of tilorone, and an efficient, safe, cost effective method for the preparation of 2,7-bis-[2-(diethylamino)ethoxy]-fluorenone-9 and its various salts are developed. The methods involve oxygenation of fluorene, nitration of fluorenone, followed by reduction and diazotization toward the formation of 2,7-dihydroxy-9-fluorenone, which is the key intermediate for the formation of 2,7-bis-[2-(diethylamino)ethoxy]-9-fluorenone-dihydrochloride (Tilorone dihydrochloride) and other tilorone salts. The synthesis method has relatively simple operation, mild reaction conditions, high yield, and simple process with yields of 80-97%. Subsequent product purification of this method uses filtration and crystallization methods, avoiding the existing methods of column chromatography. Therefore, the research of its synthetic method being with a wide range of applications from the drug development and material synthesis point of view.

专利号:US-5545568-A
优先权日:1992-09-14
标题:Solid phase and combinatorial synthesis of compounds on a solid support
发明人：ELLMAN JONATHAN A
权利人:UNIV CALIFORNIA
摘要:Methods, compositions, and devices for synthesizing combinatorial libraries of various useful compounds, such as benzodiazepines, prostaglandins, β-turn mimetics and glycerol-derived drugs is described. In order to expediently synthesize such combinatorial libraries of derivatives based upon these core structures, a general methodology for the solid phase synthesis of these derivatives is also provided. This disclosure thus also describes an important extension of solid phase synthesis methods to nonpolymeric organic compounds.

专利号:US-11655264-B2
优先权日:2015-11-25
标题:Metallocene compounds, and preparation and use thereof for synthesis of poly-alpha-olefins as lubricating base oil
发明人：WEI DONGCHU; LI BING
权利人:APALENE TECH CO LTD JIAXING
摘要:The present invention relates to a metallocene compound, and preparation and use thereof, and the compound can be used as a catalyst for synthesis of poly-α-olefin as lubricating base oil. The metallocene compound includes a substituted aryl group, a bridged atom, an optionally unsubstituted, 3-mono-substituted or 3,6-disubstituted 5H-indeno [1,2-b] pyridyl group or optionally unsubstituted, 3-mono-substituted or 3,6-disubstituted 5H-indeno [1,2-b] thiopyranyl group, and a metal coordination group. As a catalyst, the metallocene compound is shown to be structurally stable and high in catalytic efficiency, and the preparation of the catalyst is relatively easy in operation, high in yield, low in cost, low in pollution and easy to scale up for industrial production.

专利号:US-2007122842-A1
优先权日:2005-11-30
标题 :Massively parallel synthesis of proteinaceous biomolecules
发明人：RAJASEKARAN JOHN J; TIWARI GUNJAN; CABEZAS EDELMIRA; FIDANZA JACQUELINE A; SUNDARARAJAN NARAYAN
权利人:RAJASEKARAN JOHN J; TIWARI GUNJAN; CABEZAS EDELMIRA; FIDANZA JACQUELINE A; SUNDARARAJAN NARAYAN
摘要:Methods for fabricating dense arrays of polymeric molecules in a highly multiplexed manner are provided using semiconductor-processing-derived lithographic methods. Advantageously, the methods are adaptable to the synthesis of a variety of polymeric compounds. For example, arrays of peptides and polymers joined by peptide bonds may be fabricated in a highly multiplexed manner.

专利号:US-5914431-A
优先权日:1996-09-23
标 题 :Cocatalysts for the synthesis of bisphenols
发明人：FENNHOFF GERHARD
权利人:BAYER AG
摘要:The invention relates to the synthesis of bisphenols from monophenols and carbonyl compounds such as aldehydes and ketones using concentrated mineral acids such as hydrochloric acid and/or hydrogen chloride gas as acid catalysts and a mercaptan as cocatalyst, which is fixed by an ion pair bond to a matrix that is insoluble in the reaction medium.

专利号:US-2007122841-A1
优先权日:2005-11-30
标题:Massively parallel synthesis of proteinaceous biomolecules
发明人：RAJASEKARAN JOHN J; TIWARI GUNJAN; CABEZAS EDELMIRA; FIDANZA JACQUELINE A; SUNDARARAJAN NARAYAN
权利人:RAJASEKARAN JOHN J; TIWARI GUNJAN; CABEZAS EDELMIRA; FIDANZA JACQUELINE A; SUNDARARAJAN NARAYAN
摘要:Methods for fabricating dense arrays of polymeric molecules in a highly multiplexed manner are provided using semiconductor-processing-derived lithographic methods. Advantageously, the methods are adaptable to the synthesis of a variety of polymeric compounds. For example, arrays of peptides and polymers joined by peptide bonds may be fabricated in a highly multiplexed manner.