CAS: 529-64-6; 3-Hydroxy-2-Phenylpropanoic Acid

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CAS号15231-78-4 2,2-二甲基-5-苯基-1,... | CAS号1570-95-2 2-苯基-1,3-丙二醇 | CAS号103-82-2 苯乙酸 | CAS号50-00-0 甲醛 | CAS号51545-26-7 3-chloro-2-phen... | CAS号1068-55-9 异丙基氯化镁 | CAS号51-55-8 阿托品； 颠茄碱 | CAS号27150-91-0 3-phenyloxetan-2-one | CAS号51-34-3 东莨菪碱 | CAS号492-38-6 2-苯基丙烯酸 | CAS号51-55-8 阿托品； 颠茄碱 | CAS号27150-91-0 3-phenyloxetan-2-one | CAS号14510-37-3 乙酰托品酰氯 | CAS号1865-29-8 2-苯基丙烯酸甲酯 | CAS号1528-39-8 2-Pentanone, 3-... | CAS号918159-31-6 2-(2-hydroxy-1-... | CAS号4842-45-9 1,2,3-triphenyl... | CAS号3967-53-1 托品酸甲酯 | CAS号100-52-7 苯甲醛

专利信息

专利号:US-2023157936-A1
优先权日:2021-11-24
标 题 :Anti-aging skin peel composition and method of application
发明人：ZAHR ALISAR; NGUYEN THU Q; KOCH JOHN; KELLY TATIANA
权利人:JAMRM LLC
摘要:A skincare composition and a method for removing layers of skin in a cosmetic procedure. The skincare composition comprises active ingredients mixed into a cosmetically acceptable carrier. The active ingredients include an effective amount of one or more keratolytic agents for inducing a desired degree of keratolysis in the skin, an effective amount of one or more free radical neutralizing agents for negating cellular damage from reactive chemical species, and an effective amount of one or more agents increasing synthesis of dermal components. The one or more free radical neutralizing agents and the one or more agents increasing synthesis of dermal components are acids in their un-neutralized, natural acid form, and a total amount of the active ingredients is less than 50 w/w% of the skincare composition, and a pH of the skincare composition is between 1.5-3.5.

专利号:US-2004110228-A1
优先权日:2002-04-01
标 题:Combinatorial organic synthesis of unique biologically active compounds
发明人：MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.

专利号:US-9453037-B2
优先权日:2011-07-28
标 题 :Methylphenidate-prodrugs, processes of making and using the same
发明人：GUENTHER SVEN; CHI GUOCHEN; BERA BINDU; MICKLE TRAVIS; BERA SANJIB
权利人:KEMPHARM INC; KEMPHARM INC
摘要:The present technology is directed to prodrugs and compositions for the treatment of various diseases and/or disorders comprising methylphenidate, or methylphenidate derivatives, conjugated to at least one alcohol, amine, oxoacid, thiol, or derivatives thereof. In some embodiments, the conjugates further include at least one linker. The present technology also relates to the synthesis of methylphenidate, or methylphenidate derivatives, conjugated to at least one alcohol, amine, oxoacid, thiol, or derivatives thereof or combinations thereof.

专利号:US-8138272-B2
优先权日:2006-05-22
标 题:Preparation of polymer conjugates of therapeutic, agricultural, and food additive compounds
发明人：KONRADI ANDREI W; SMITH JENIFER L
权利人:KONRADI ANDREI W; SMITH JENIFER L; ELAN PHARM INC
摘要:This invention provides an improved synthesis of polymer conjugates of formula (I), n nof agricultural, therapeutic, and food additive compounds. In particular, a process is described for the preparation of conjugates by treating primary or secondary alcohol substituents of active compounds with polymeric nucleophiles using “Mitsunobuâ€? or related reaction conditions.

专利号:US-3940421-A
优先权日:1971-12-20
标题 :Intermediates for the preparation of thienobenzopyrans and thiopyranobenzopyrans
发明人：RAZDAN RAJ K; PARS HARRY G
权利人:LITTLE INC A
摘要:Novel thienobenzopyrans and thiopyranobenzopyrans represented by the formula ##SPC1## n Wherein m and n are each 0, 1, 2 or 3 and m + n is 2 or 3; R 1 is loweralkyl; R 2 is alkyl or cycloalkylloweralkyl and R 3 is hydrogen, loweralkyl, loweralkanoyl, carbamyl, N-loweralkylcarbamyl, N,N-diloweralkylcarbamyl, phosphonyl, hemisuccinate or an ester of another such acid, phosphate, dialkylaminoalkyl of the structure ##EQU1## or acid addition salt thereof, or dialkylaminoalkylanoyl of the structure ##EQU2## or acid addition salt thereof, wherein x is 1 through 6 and R 4 and R 5 are loweralkyl; the loweralkyl groups containing from 1 through 6 carbon atoms, the alkyl groups containing from 1 through 20 carbon atoms and the cycloalkyl groups containing from 3 through 8 ring carbon atoms. Novel intermediates for the synthesis of these compounds are also disclosed as well as methods for making the compounds.

专利号:WO-2024054881-A1
优先权日:2022-09-07
标题:Ligand-enabled scalable c-h hydroxylation of benzoic and phenylacetic acids at room temperature
发明人：YU JIN-QUAN; LI ZHEN; PARK HAN
权利人:SCRIPPS RESEARCH INST
摘要:The application discloses industry scalable methods of using bifunctional bidentate pyridone-carboxylic acid ligands, such as 2-methyl-2-(6-oxo-1,6-dihydropyridin-2-yl)propanoic acid, that enable room-temperature Pd-catalyzed C-H hydroxylation of a broad range of benzoic and phenylacetic acids with an industry-compatible oxidant, aqueous hydrogen peroxide, at room temperature. Further disclosed are methods of derivatization of the resulting hydroxylation products, synthesis of polyfluorinated natural products coumestan or pterocarpene from phenol building blocks, and hydroxylation of ibuprofen using this methodology,