CAS: 65796-00-1; 1-(Chloromethyl)-4-(Trifluoromethoxy)Benzene

上下游产品

CAS号456-55-3 三氟甲氧基苯 | CAS号1736-74-9 4-(三氟甲氧基)苄醇 | CAS号330-12-1 4-(三氟甲氧基)苯甲酸

三氟甲氧基苯置于盐酸,碳酸氢钠,Paraformaldehyde体系中,用 甲醇,甲基叔丁基醚,水 作为反应溶剂,以65%的收率获得产物4-三氟甲氧基氯苄
参考文献:Process For Preparing 2-(4-Trifluoromethoxyphenyl)Ethylamine And 4-Bromomethyl-And 4-Chloromethyl-1-Trifluoromethoxybenzene
标题:Process For Preparing 2-(4-Trifluoromethoxyphenyl)Ethylamine And 4-Bromomethyl-And 4-Chloromethyl-1-Trifluoromethoxybenzene
摘要:该发明涉及一种制备2-(4-三氟甲氧基苯基)乙胺的方法,通过以下步骤实现:(A) 将三氟甲氧基苯转化为卤甲基化合物,得到卤代甲基-1-三氟甲氧基苯;(B) 将卤代甲基-1-三氟甲氧基苯通过卤-氰交换反应转化为4-(三氟甲氧基苯基)乙腈;(C) 在镍催化剂存在下,使用氢气还原4-(三氟甲氧基苯基)乙腈,得到2-(4-三氟甲氧基苯基)乙胺.该方法的第一步也是制备4-溴甲基和4-氯甲基-1-三氟甲氧基苯的优势方法.

专利信息

专利号:US-7999090-B2
优先权日:2000-07-07
标 题:Fungal cell wall synthesis gene
发明人：TSUKAHARA KAPPEI; HATA KATSURA; SAGANE KOJI; NAKAMOTO KAZUTAKA; TSUCHIYA MAMIKO; WATANABE NAOAKI; OHBA FUMINORI; TSUKADA ITARU; UEDA NORIHIRO; TANAKA KEIGO; KAI JUNKO
权利人:EISAI R&D MAN CO LTD
摘要:The present invention provides isolated DNA encoding a GWT1 protein having activity to confer resistance of a fungus against a compound of formula Ia, and wherein a defect of a function of the GWT1 protein leads to a decrease in the amount of a glycosylphosphatidylinositol (GPI)-anchored protein in the cell wall of a fungus.

专利号:NO-332798-B1
优先权日:1999-10-12
标 题:Intermediates for the synthesis of C-aryl-glucoside-SGLT2 inhibitors