专利号:US-7572916-B2 优先权日:2004-05-03 标 题 :Diastereoselective synthesis process with 6-bromo-4-(3-chlorophenyl)-2-methoxy-quinoline 发明人:FILLIERS WALTER FERDINAND MARIA; BROECKX RUDY LAURENT MARIA; ANGIBAUD PATRICK RENE 权利人:JANSSEN PHARMACEUTICA NV 摘要:A diastereoselective synthesis process for the preparation of (R)-(+)-6-[amino(4chlorophenyl)(1-methyl-1H-imidazol-5-yl) methyl]-4-(3-chlorophenyl)-1-methyl2(1H)-quinolinone which comprises the preparation of a compound of formula (XVII): and the stereochemically isomeric forms thereof wherein R is C1-6alkyl or C1-6alkylphenyl.
专利号:US-7456287-B2 优先权日:2004-05-03 标 题:Diastereoselective synthesis process for the preparation of imidazole compounds 发明人:FILLIERS WALTER FERDINAND MARIA; BROECKX RUDY LAURENT MARIA; ANGIBAUD PATRICK RENE 权利人:JANSSEN PHARMACEUTICA NV 摘要:A diastereoselective synthesis process for the preparation of an enantiomer of 6-[amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl]-4-(3-chlorophenyl)-1-methyl-2(1H)-quinolinone which comprises the conversion of (±)-6-[chloro(4-chlomphenyl)(1-methyl-1H-imidazol-5-yl)methyl]-4-(3-chlorophenyl)-1-methyl-2(1H)-quinolinone into a compound of formula (VIII) wherein aryl is phenyl substituted once or twice with C 1-6 alkyloxy or naphtalenyl substituted once or twice with C 1-6 alkyloxy.
专利号:US-5665882-A 优先权日:1994-03-14 标题 :Pyridyl ethylation of lactams 发明人:CHUNG JOHN Y L; ZHAO DALIAN; MCNAMARA JAMES M; HUGHES DAVID L 权利人:MERCK & CO INC 摘要:PCT No. PCT/US94/12671 Sec. 371 Date Aug. 29, 1996 Sec. 102(e) Date Aug. 29, 1996 PCT Filed Nov. 7, 1994 PCT Pub. No. WO95/25101 PCT Pub. Date Sep. 21, 1995The invention is a highly efficient synthesis for making compounds of formula: wherein n=0, 1, R is C1-4 alkyl or benzyl; and R1, when present, is C1-4 alkyl, OH, O-C1-4 alkyl or S-C1-4 alkyl. The process involves silane-mediated conjugation of 4-vinylpyridine to a substituted lactam.
专利号:US-5202444-A 优先权日:1990-11-27 标题:Optically isomeric inositol and process for making optically active compound 发明人:OZAKI SHOICHIRO; AKIYAMA TAKAHIKO; KAGEYAMA KUNIO; MACHIDA MORIHISA 权利人:YOKOHAMA RUBBER CO LTD 摘要:Optically active diols and hydroxycarboxylic acids and their esters are produced by deriving 1L-1,2:5,6-di-O-cyclohexylidene-chiro-inositol from 1L-chiro-inositol as an asymmetric source, followed by introduction of a selected class of sterically hindering and asymmetrically reactive groups into the first-mentioned compound and by subsequent reduction of the resulting compound. Seven specific inositols are also derivable from synthesis of those ultimate compounds.
专利号:US-7524961-B2 优先权日:2004-05-03 标题 :Diastereoselective addition of lithiated N-methylimidazole on sulfinimines 发明人:FILLIERS WALTER FERDINAND MARIA; BROECKX RUDY LAURENT MARIA; ANGIBAUD PATRICK RENE 权利人:JANSSEN PHARMACEUTICA NV 摘要:A diastereoselective synthesis process for the preparation of (R)-(+)-6-[amino(4-chlorophenyl) (1-methyl-1H-imidazol-5-yl)methyl]-4-(3-chlorophenyl)-1-methyl-2 (1H)-quinolinone which comprises the preparation of a compound of formula (VIII) n nand the stereochemically isomeric forms thereof wherein R is C 1-6 alkyl or C 1-6 alkylphenyl-.
专利号:US-9416147-B2 优先权日:2014-04-03 标题 :Preparation of silazane compound 发明人:TONOMURA YOICHI; KUBOTA TOHRU 权利人:SHINETSU CHEMICAL CO 摘要:A silazane compound useful as synthesis intermediates for paint additives, polymer modifiers, pharmaceuticals and agricultural chemicals is efficiently prepared by reaction of a halosilane compound with an amino-containing compound in a solvent which is the same silazane compound as the target product.
参考标题:Asymmetric Synthesis Of 2-Alkyl(Aryl)-2,3-Dihydro-4-Pyridones By Addition Of Grignard Reagents To Chiral 1-Acyl-4-Methoxypyridinium Salts 作者:Daniel L. Comins,Sajan P. Joseph,R. Richard Goehring |发布日期:1994.6 摘要:Grignard Addition To A Chiral 1-Acyl-4-Methoxypyridinium Salt Provides Synthetically Useful 2-Alkyl(Aryl)-2,3-Dihydro-4-Pyridones In High Diastereomeric Excess
合成参考文献
摘要:Pietruszka, J., Science of Synthesis, (2002) 4, 168.