CAS: 195062-57-8; 4,4,5,5-Tetramethyl-2-(P-Tolyl)-1,3,2-Dioxaborolane

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CAS号106-38-7 对溴甲苯 | CAS号61676-62-8 2-异丙氧基-4,4,5,5-... | CAS号106-43-4 对氯甲苯 | CAS号73183-34-3 双戊酰二硼 | CAS号624-31-7 对碘甲苯 | CAS号76-09-5 频哪醇 | CAS号459-44-9 4-methylbenzene... | CAS号22092-92-8 N,N-二异丙基氨基硼烷 | CAS号25015-63-8 频那醇硼烷 | CAS号5720-05-8 对甲基苯基硼酸 | CAS号5748-38-9 4-乙酰基-4'-甲基联苯 | CAS号52988-34-8 4'-甲氧基联苯-4-甲醛 | CAS号19493-33-5 4-METHYL-2-CHLO... | CAS号36393-42-7 4'-甲基联苯-4-甲醛 | CAS号100-39-0 溴化苄 | CAS号53040-92-9 4-甲氧基-4-甲基-联苯 | CAS号23674-14-8 Anthracene,9-(4... | CAS号195062-59-0 4,4,5,5-四甲基-2-(... | CAS号253342-48-2 3-甲基苯硼酸频呐醇酯 | CAS号7148-03-0 2-(对甲苯基)苯甲酸

N,N-二甲基对甲苯胺置于bis(1,5-Cyclooctadiene)Nickel (0),三丁基膦,Sodium T-Butanolate体系中,用 1,4-二氧六环,二氯甲烷 用作溶剂,化学反应 28.0H,反应生成对甲基苯硼酸频哪醇酯
参考文献:制作二甲氨基可转化用镍催化ç导演组n硼化
标题:制作二甲氨基可转化用镍催化ç导演组n硼化
摘要:二甲基氨基(me 2 N)基团可以说是最通用的官能团,能够根据反应条件在邻位,间位和对位进行高效和位点选择性的定向芳族官能化.尽管me 2 N定向反应的库迅速增长,但缺乏通用的方法将该基团转变为其他官能团,妨碍了其在有机合成中的广泛应用.这里,我们报告镍-催化的ç 芳基-和苄基二甲胺,其允许未充分利用的me很大程度上是巨大的图书馆的转换n个borylations 2含n的有机分子成各种功能性分子通过利用现有的c财富的优点乙官能的方法.
Doi:10.1002/chem.201503596

专利信息

专利号:WO-2012173572-A1
优先权日:2011-06-10
标 题 :Stereoselective synthesis of highly substituted enamides
发明人：PARK CHEOL-MIN; LIU YU
权利人:UNIV NANYANG TECH; PARK CHEOL-MIN; LIU YU
摘要:The disclosure provides new methods for the oxidative Heck cross-coupling reaction with electron-rich alkenes such as substituted β-amidoacrylate and other related substituted enamides. Previously, functionalization of enamides under Heck conditions has been limited to those with unsubstituted vinyl groups. By tuning the reaction parameters that allow for the balance between stability and reactivity of the reactants, the oxidative Heck cross-coupling reaction now provides highly substituted enamides in good to excellent yields. (II) (III) (I)·

专利号:US-9243004-B2
优先权日:2011-07-22
标题 :Synthesis of boronic esters and boronic acids using grignard reagents
发明人：CLARY JACOB W; SINGARAM BAKTHAN
权利人:CLARY JACOB W; SINGARAM BAKTHAN; UNIV CALIFORNIA
摘要:Boronic esters and boronic acids are synthesized at ambient temperature in an ethereal solvent by the reaction of Grignard reagents with a boron-containing substrate. The boron-containing substrate may be a boronic ester such as pinacolborane, neopentylglycolborane, or a dialkylaminoborane compound such as diisopropylaminoborane. The Grignard reagents may be pre-formed or generated from an alkyl, alkenyl, aryl, arylalkyl, heteroaryl, vinyl, or allyl halide compound and Mg 0 . When the boron-containing substrate is a boronic ester, the reactions generally proceed at room temperature without added base in about 1 to 3 hours to form a boronic ester compound. When the boron-containing substrate is a dialkylaminoborane compound, the reactions generally proceed to completion at 0° C. in about 1 hour to form a boronic acid compound.

专利号:US-9708336-B2
优先权日:2014-01-22
标题 :Metallo-beta-lactamase inhibitors
发明人：MANDAL MIHIR; TANG HAIFENG; XIAO LI; SU JING; LI GUOQING; YANG SHU-WEI; PAN WEIDONG; TANG HAIQUN; DEJESUS REYNALDA; HICKS JACQUELINE; LOMBARDO MATTHEW; CHU HONG; HAGMANN WILLIAM; PASTERNAK ALEX; GU XIN; JIANG JINLONG; DONG SHUZHI; DING FA-XIANG; LONDON CLARE; BISWAS DIPSHIKHA; YOUNG KATHERINE; HUNTER DAVID N; ZHAO ZHIQIANG; YANG DEXI
权利人:MERCK SHARP & DOHME
摘要:The present invention relates to compounds of formula (I) that are metallo-β-lactamase inhibitors, the synthesis of such compounds, and the use of such compounds for use with β-lactam antibiotics for overcoming resistance.

专利号:US-7122694-B2
优先权日:1998-11-06
标 题 :Hydroboronation process
发明人：MARCUCCIO SEBASTIAN MARIO; RODOPOULOS MARY; WEIGOLD HELMUT
权利人:BORON MOLECULAR PTY LTD
摘要:The invention relates to processes for the synthesis of aryl or alkene borates which comprises reacting: (i) an olefinic compound having a halogen or halogen-like substituent in a vinylic substitution position, or (ii) an aromatic ring having a halogen or halogen-like substituent in a ring substitution position, with a disubstituted monohydroborane in the presence of a Group 8-11 metal catalyst. The invention also relates to the use of these borates in coupling reactions. The invention further relates to certain disubstituted monohydroboranes and aryl or alkene borates.

专利号:US-2015119580-A1
优先权日:2011-07-22
标 题 :Synthesis of boronic esters and boronic acids using grignard reagents

专利号:WO-2013016185-A1
优先权日:2011-07-22
标 题 :Synthesis of boronic esters and boronic acids using grignard reagents