CAS: 2516-96-3; 2-Chloro-5-Nitrobenzoic Acid

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CAS号6361-21-3 2-氯-5-硝基苯甲醛 | CAS号118-91-2 邻氯苯甲酸 | CAS号13290-74-9 2-氯-5-硝基甲苯 | CAS号16588-15-1 2-氯-5-硝基苯甲酰胺 | CAS号16588-02-6 2-氯-5-硝基苯甲腈 | CAS号95-51-2 2-氯苯胺 | CAS号96-97-9 5-硝基水杨酸 | CAS号54253-05-3 2-chloro-N-(4-c... | CAS号873-32-5 邻氯苯腈 | CAS号89-98-5 邻氯苯甲醛 | CAS号61346-19-8 5-硝基-1,2-二氢-3H-... | CAS号40751-89-1 2-甲氧基-5-硝基苯甲酸 | CAS号34841-11-7 2-甲氧基-5-硝基苯甲酸甲酯 | CAS号34052-37-4 2-氯-5-硝基二苯甲酮 | CAS号50-79-3 2,5-二氯苯甲酸 | CAS号4036-83-3 2-吗啉-5-硝基苯甲酸 | CAS号42122-75-8 2-氯-5-氨基苯甲酸甲酯 | CAS号42106-50-3 5-硝基-2-哌啶-1-基苯甲酸 | CAS号18803-19-5 (2-hydroxy-5-ni... | CAS号197653-87-5 (2-chloro-5-nit...

2-氯苯甲酸置于硫酸,Potassium Nitrate体系中,化学反应 3.0H,以90.2%的收率获得2-氯-5-硝基苯甲酸
参考文献:设计,合成和生物学评估作为拓扑异构酶i抑制剂的3-取代的茚并异喹啉衍生物
标题:设计,合成和生物学评估作为拓扑异构酶i抑制剂的3-取代的茚并异喹啉衍生物
摘要:设计并合成了一系列新的茚并异喹啉衍生物.在hepg2,A549和hct-116细胞系中评估了这些新型化合物的体外抗增殖活性.化合物9A,9B,10A,10C,10E,18A和18B表现出对三种测试癌细胞系的有效抑制活性.还测试了19种化合物在50μm下对top I的抑制作用.在该浓度下,几乎所有测试的化合物都显示出有效的top I抑制活性.最有效的化合物9A和10A 与hcpt和tpt相比,它具有更高的细胞毒性,并且在我们的生物学分析中,对top I的抑制活性可与cpt相媲美.
Doi:10.1016/j.Bmcl.2015.12.014

专利信息

专利号:US-5654441-A
优先权日:1995-09-14
标 题 :Synthesis of 1,3-oxathiolane sulfoxide compounds
发明人：MCPHEE DEREK JAMES
权利人:UNIROYAL CHEMICAL LTD
摘要:A process for the production of a 1,3-oxathiolane sulfoxide of the formula ##STR1## wherein X is an amino group of the formula --NHR, wherein R is hydrogen, phenyl, C 1 -C 8 alkyl, C 3 -C 6 cycloalkyl, nitrophenyl, (C 1 -C 4 alkoxy)phenyl, furfuryl, halophenyl, tolyl, napthyl, biphenyl or hydroxyphenyl; or X is an alkoxy group of the formula --OR 1 wherein R is C 1 -C 6 alkyl, n which process comprises oxidizing a 1,3-oxathiolane of the formula ##STR2## wherein X is as defined above, in the presence of an effective amount of aqueous hydrogen peroxide and a sterically-hindered organoselenium compound of the formula ##STR3## wherein R 2 is aryl, mono-, di- or tri-substituted with C 1 -C 3 alkyl, n to the produce the 1,3-oxathiolane sulfoxide. This process stereoselectively produces the cis stereoisomer of the 1,3-oxathiolane sulfoxide. Additionally, there is disclosed a novel method for the preparation of 5,6-dihydro-2-methyl-1,4-oxathiin compounds using this process.

专利号:US-7943723-B2
优先权日:2006-12-21
标 题:Process for the synthesis of ethers of aromatic acids
发明人：RITTER JOACHIM C
权利人:DU PONT
摘要:The inventions disclosed herein include processes for the preparation of an ether of an aromatic acid, processes for the preparation of products into which such an ether can be converted, the use of such processes, and the products obtained and obtainable by such processes. A key feature of the processes described is the use of a solvent comprising an alcohol ROH and an alcoholate RO − M + .

专利号:US-8207374-B2
优先权日:2006-12-21
标 题:Process for the synthesis of ethers of aromatic acids
发明人：RITTER JOACHIM C
权利人:RITTER JOACHIM C; DU PONT
摘要:Ethers of aromatic acids are produced from halogenated aromatic acids in a reaction mixture containing a copper (I) or copper (II) source and a diketone ligand that coordinates to copper.

专利号:US-2011060118-A1
优先权日:2009-09-02
标 题:Process for the synthesis of fluorinated ethers of aromatic acids
发明人：RITTER JOACHIM C; MOLOY KENNETH GENE; POLLINO JOEL M; MAHAJAN DU SURBHI
权利人:DU PONT
摘要:Fluorinated ethers of aromatic acids are produced from halogenated aromatic acids in a reaction mixture containing a copper (I) or copper (II) source and a Schiff base ligand that coordinates to copper. The fluorinated ethers of aromatic acids made using the process described herein can be applied to, e.g., fibers, yarns, carpets, garments, films, molded parts, paper and cardboard, stone, and tile to impart soil, water and oil resistance. By incorporating the fluorinated ethers of aromatic acids, or diesters thereof, into polymer backbones, more lasting soil, water and oil resistance, as well as improved flame retardance, can be achieved.

专利号:US-7985825-B2
优先权日:2006-12-21
标 题 :Process for the synthesis of ethers of aromatic acids
发明人：RITTER JOACHIM C
权利人:DU PONT
摘要:Ethers of aromatic acids are produced from halogenated aromatic acids in a reaction mixture containing a halogenated aromatic acid such as is described by the structure of Formula II n nwherein each X is independently Cl, Br or I; the reaction mixture further comprising;n (i) a polar protic solvent, a polar aprotic solvent or an alcoholic solvent containing the alcoholate RO-M+ (wherein M is Na or K), wherein the polar protic solvent, polar aprotic solvent or alcoholic solvent is either ROH or is a solvent that is less acidic than ROH; (ii) a copper (I) or copper (II) source; and (iii) an amino acid ligand that coordinates to copper, wherein the ligand comprises an amino acid in which the amine nitrogen and the carboxyl carbon are separated by no more than two carbon atoms.

专利号:US-4895954-A
优先权日:1986-07-26
标题 :Precursors for synthesis of triphendioxazine dyestuffs
发明人：SCHWAIGER GUENTHER; SPRINGER HARTMUT; HELMLING WALTER
权利人:HOECHST AG
摘要:Water-soluble triphendioxazine compounds which have fiber-reactive properties as dyestuffs, which afford deep and fast dyeings on fiber materials, such as wool and, in particular, cellulose, and which correspond to the formula (1) ##STR1## in which: n is the number 0 or 1; n Y is the vinyl group or an ethyl group containing, in β-position, a substituent which can be eliminated by means of an alkali; n Q 1 and Q 2 both represent a benzotriazole radical which can also be additionally substituted in the benzene nucleus by alkyl having 1 to 4 carbon atoms, alkoxy having 1 to 4 carbon atoms, halogen, carboxy or sulfo; n B is --O--, --S--, --NH-- or --N(R')-- wherein R' is optionally substituted alkyl having 1 to 6 carbon atoms; n W 1 and W 2 both represent a divalent, optionally substituted aliphatic, cycloaliphatic, aliphatic-cycloaliphatic, araliphatic or aromatic-carbocyclic radical, it being possible for the aliphatic radicals to be interrupted by hetero groups --O--, --S--, --SO 2 --, --CO--, 1,4-piperidino, --NH-- and/or --N(R o )-- in which R o is optionally substituted alkyl having 1 to 6 carbon atoms or alkanoyl having 2 to 5 carbon atoms, and/or for aliphatic and aryl radicals to be attached to one another through such a hetero group; n R is hydrogen, alkyl having 1 to 6 carbon atoms, alkoxy having 1 to 6 carbon atoms, halogen, carboxyl or sulfo; n E is hydrogen, sulfo, carboxyl, a group --SO 2 --Y as defined above or an optionally substituted sulfonamide group; and n X 1 and X 2 are both hydrogen or halogen, cycloalkyl, alkoxy, aryloxy, aryl or another substituent; n and at least one carboxy, sulfo or sulfato group is present in the molecule (1), n and pre-products of those triphendioxazine compounds, of the general formula ##STR2## in which K is an amino or nitro group, Y' is β-hydroxyethyl or defined as for Y, W has one of the meanings of W 1 , and E' is hydrogen, sulfo, carboxy or a group of the formula --SO 2 --Y' defined above, or an optionally substituted sulfonamide group, and R, B and R* have the above meanings.