CAS: 700-36-7; 2-Bromo-4-Fluoro-1-Nitrobenzene

上下游产品

CAS号371-40-4 4-氟苯胺 | CAS号1003-98-1 2-溴-4-氟苯胺 | CAS号1073-06-9 间溴氟苯 | CAS号540-80-7 亚硝酸叔丁酯 | CAS号369-36-8 2-氟-5-硝基苯胺 | CAS号408355-23-7 7-溴-5-氟-1H-吲哚 | CAS号399-52-0 5-氟吲哚 | CAS号400-91-9 3-溴-4,6-双氟甲苯 | CAS号875305-87-6 5-氟-1H-吲哚-7-羧酸 | CAS号883001-24-9 7-溴-5-氟-3-甲基-1H-吲哚 | CAS号131885-34-2 N-苄基-5-氟-2-硝基苯胺 | CAS号1265623-60-6 2-Ethynyl-4-flu... | CAS号1717-22-2 5-Fluorobipheny... | CAS号1258545-24-2 2-Bromo-1-nitro... | CAS号169674-02-6 4-氯-5-氟吲哚

4-氟苯胺置于n-溴代丁二酰亚胺(Nbs),Tetrafluoroboric Acid,溶剂黄146,Sodium Nitrite体系中,化学反应生成 2-溴-4-氟-1-硝基苯
参考文献:一种3-溴-4-溴硝基苯酚的制备方法
标题:一种3-溴-4-溴硝基苯酚的制备方法
摘要:本发明公开了一种3‑溴‑4‑溴硝基苯酚的工业化制备方法.该3‑溴‑4‑溴硝基苯酚的工业化制备方法,以对氟苯胺为初始原料,经上溴,重氮化上硝基以及水解三步反应合成3‑溴‑4‑溴硝基苯酚.本过程得到的3‑溴‑4‑溴硝基苯酚为黄色固体,纯度97.5%,每步原料转化率分别达到100%,整个过程的总收率达到25.8%.

专利信息

专利号:US-8735586-B2
优先权日:2007-06-26
标 题 :Regioselective copper catalyzed synthesis of benzimidazoles and azabenzimidazoles
发明人：ALONSO JORGE; LINDENSCHMIDT ANDREAS; NAZARÉ MARC; URMANN MATTHIAS; HALLAND NIS; RKYEK OMAR
权利人:ALONSO JORGE; LINDENSCHMIDT ANDREAS; NAZARÉ MARC; URMANN MATTHIAS; HALLAND NIS; RKYEK OMAR; SANOFI SA
摘要:The present invention relates to a process for the regioselective synthesis of compounds of the formula I, n nwherein R0; R1; R2; R3; R4; R5; A1; A2; A3; A4, Q and J have the meanings indicated in the claims. The present invention provides a direct copper catalyzed regioselective process to a wide variety of unsymmetrical, multifunctional N-substituted benzimidazoles or azabenzimidazoles of formula I starting from 2-halo-nitroarenes and N-substituted amides.

专利号:US-2010261909-A1
优先权日:2007-06-26
标题 :Regioselective copper catalyzed synthesis of benzimidazoles and azabenzimidazoles

专利号:WO-2009000413-A1
优先权日:2007-06-26
标题:A regioselective copper catalyzed synthesis of benzimidazoles and azabenzimidazoles

专利号:US-12384788-B2
优先权日:2019-09-13
标 题 :1,4-dihydrobenzo[d]pyrazolo[3,4-f][1,3]diazepine derivatives and related compounds as LRRK2, NUAK1 and/or TYK2 kinase modulators for the treatment of e.g. autoimmune disease
发明人：KOESTLER ROLAND; TASSEL JEAN; THORMANN MICHAEL; YEHIA NASSER; TREML ANDREAS; ALMSTETTER MICHAEL
权利人:ORIGENIS GMBH
摘要:The present invention relates to compounds of formula (I) that are capable of modulating, e.g., inhibiting or activating, one or more kinases, especially LRRK2 and/or NUAK1 and/or TYK2 or mutants thereof. The compounds are useful for treating diseases, such as autoimmune diseases, inflammatory diseases, bone diseases, metabolic diseases, neurological and neurodegenerative diseases, cancer, cardiovascular diseases, allergies, asthma, Alzheimer's disease, Parkinson's disease, skin disorders, eye diseases, infectious diseases and hormone-related diseases. The present description discloses the synthesis and characterisation of exemplary compounds as well as pharmacological data thereof (e.g. pages 40 to 146; examples 1 to 63; compounds 1 to 248; tables 1 to 3). Preferred compounds are e.g. 1,4-dihydrobenzo[d]pyrazolo[3,4-f][1,3]diazepine derivatives and related compounds. An exemplary compound is e.g. 5-(2,6-difluorophenyl)-8-methoxy-1,4-dihydrobenzo[d]pyrazolo[3,4-f][1,3]diazepine (example 49). (Formula (II):

专利号:AU-2008267444-A1
优先权日:2007-06-26
标 题 :A regioselective copper catalyzed synthesis of benzimidazoles and azabenzimidazoles

专利号:EP-2173721-B1
优先权日:2007-06-26
标 题:A regioselective copper catalyzed synthesis of benzimidazoles and azabenzimidazoles