CAS: 74204-00-5; 3-Bromo-5-Methylphenol

上下游产品

CAS号58169-99-6 2,3,4,6-Tetrabr... | CAS号591-17-3 3-溴甲苯 | CAS号29578-83-4 1-溴-3-甲氧基-5-甲苯 | CAS号14472-14-1 4-溴-3-甲基苯酚 | CAS号34946-83-3 2,4,4,6-tetrabr... | CAS号108-39-4 间甲酚 | CAS号4619-74-3 2,4,6-三溴-3-甲基苯酚 | CAS号74586-53-1 3-溴-5-甲基苯胺 | CAS号7446-70-0 氯化铝 | CAS号71-43-2 苯 | CAS号5367-32-8 3-甲基-4-硝基苯甲醚 | CAS号38512-82-2 5-甲基-2-硝基苯甲醚 | CAS号504-15-4 3,5-二羟基甲苯 | CAS号29578-83-4 1-溴-3-甲氧基-5-甲苯 | CAS号31601-41-9 2-乙酰氨基-5-甲氧基甲苯 | CAS号5345-42-6 3-甲基-2-硝基苯甲醚 | CAS号82994-17-0 3,7-dimethoxy-1... | CAS号89345-81-3 N-(2-甲氧基-4-甲基苯基)-乙酰胺 | CAS号90674-26-3 3-甲氧基-5-甲基苯甲醛 | CAS号59297-29-9 1-溴-3-(溴甲基)-5-甲氧基苯

2,3,6-三溴对甲酚置于硫酸,氢碘酸,溴,溶剂黄146体系中,化学反应 4.12H,反应生成 3-溴-5-甲基苯酚
参考文献:Brittain,Judith M.; Mare,Peter B. D. De La; Newman,Paul A.,Journal Of The Chemical Society. Perkin Transactions Ii,1981,P. 32-41
标题:Brittain,Judith M.; Mare,Peter B. D. De La; Newman,Paul A.,Journal Of The Chemical Society. Perkin Transactions Ii,1981,P. 32-41

专利信息

专利号:US-6828466-B2
优先权日:2002-07-19
标题:Process for the synthesis of phenols from arenes
发明人：MALECZKA JR ROBERT E; SMITH III MILTON R; HOLMES DANIEL; SHI FENG
权利人:UNIV MICHIGAN STATE
摘要:A process to synthesize substituted phenols such as those of the general formula RR'R''Ar(OH) wherein R, R', and R'' are each independently hydrogen or any group which does not interfere in the process for synthesizing the substituted phenol including, but not limited to, halo, alkyl, alkoxy, carboxylic ester, amine, amide; and Ar is any variety of aryl or hetroaryl by means of oxidation of substituted arylboronic esters is described. In particular, a metal-catalyzed C-H activation/borylation reaction is described, which when followed by direct oxidation in a single or separate reaction vessel affords phenols without the need for any intermediate manipulations. More particularly, a process wherein Ir-catalyzed borylation of arenes using pinacolborane (HBPin) followed by oxidation of the intermediate arylboronic ester by OXONE is described.

专利号:US-12150934-B2
优先权日:2016-11-30
标 题 :Methods of using substituted pyrazole and pyrazole compounds and for treatment of hyperproliferative diseases
发明人：SIDDIQUI ARSHAD M; CIBLAT STEPHANE; CONSTANTINEAU-FORGET LEA; GRAND-MAITRE CHANTAL; GUO XIANGYU; SRIVASTAVA SANJAY; SHIPPS GERALD W; COOPER ALAN B; OZA VIBHA; KOSTURA MATTHEW W; LUTHER MICHAEL; LEVINE JEDD
权利人:BANTAM PHARMACEUTICAL LLC
摘要:Disclosed are methods of treating hyperproliferative disorders such as cancer, methods of arresting the cell cycle in cancer cells, methods of inhibiting glutathione synthesis in cancer cells, and associated compounds for use and uses in medicaments. In certain embodiments, the methods, uses and compounds are provided with reference to compounds of the structural formula (I), in which X1, X2, Z1, Z2, the ring system denoted by “aâ€?, R1, L1, L2, Q, L3, R3, L4, R4, L5, and R5 are as described herein. In certain embodiments, compounds disclosed herein are especially active against cancers having a mutant KRAS gene.

专利号:US-2004030197-A1
优先权日:2002-07-19
标 题 :Process for the synthesis of phenols from arenes

专利号:US-9550757-B2
优先权日:2010-03-05
标题:Nuclear transport modulators and uses thereof
发明人：SHACHAM SHARON; KAUFFMAN MICHAEL; SANDANAYAKA VINCENT P; SHECHTER SHARON
权利人:KARYOPHARM THERAPEUTICS INC
摘要:The invention generally relates to the field of nuclear transport modulators, e.g., CRM1 inhibitors, and more particularly to new substituted-heterocyclic azole compounds, the synthesis and use of these compounds and their pharmaceutical compositions, e.g., in the treatment, modulation and/or prevention of physiological conditions associated with CRM1 activity such as in treating cancer and other neoplastic disorders, inflammatory diseases, disorders of abnormal tissue growth and fibrosis including cardiomyopathy, pulmonary fibrosis, hepatic fibrosis, glomerulonephritis, and other renal disorders, and for the treatment of viral infections (both acute and chronic).