CAS: 81335-77-5; 5-Ethyl-2-(4-Isopropyl-4-Methyl-5-Oxo-4,5-Dihydro-1H-Imidazol-2-yl)Nicotinic Acid

上下游产品

CAS号40963-14-2 2-氨基-2,3-二甲基丁酰胺 | CAS号105151-39-1 5-乙基吡啶-2,3-二羧酸二乙酯

5-乙基吡啶-2,3-二羧酸置于sodium N-Propoxide,乙酸酐体系中,用 甲苯 作为反应溶剂,化学反应 2.5H,反应生成 咪草烟
参考文献:一种咪草烟的合成方法
标题:一种咪草烟的合成方法
摘要:本发明涉及一种咪草烟的合成方法,以5‑乙基吡啶‑2,3‑二羧酸为原料,与乙酸酐反应生成5‑甲基吡啶‑2,3‑二酸酐.在低温条件下,继续与醇反应生成结构式(i)化合物,在碱性条件下与2‑氨基‑2,3‑二甲基丁酰胺发生合环反应,萃取调节ph得到咪草烟产品.本发明的优点在于:该发明路线反应速度快,产物纯度极高,收率高,反应条件温和,无同分异构体,三废少,合成过程粗放不但优化了反应条件,降低了反应的设备成本,而且产生的产品容易分离,简化了生产工艺..

专利信息

专利号:US-2008287649-A1
优先权日:2006-12-29
标 题 :Methods for the synthesis of cyclic peptides
发明人：CHEN LIN; HAN YEUN-KWEI; ROBERTS CHRISTOPHER R
权利人:CHEN LIN; HAN YEUN-KWEI; ROBERTS CHRISTOPHER R
摘要:Methods for the synthesis of cyclic peptides are provided, as well as novel dipeptide compounds. The methods include the solid phase synthesis of a dipeptide, which is the coupled to a second peptide in a solid phase reaction. The peptide is then cyclized following the coupling reaction. The methods and dipeptides are particularly useful for the synthesis of MC-4 receptor agonist peptides.

专利号:US-8486921-B2
优先权日:2006-04-07
标 题:Synthesis of tetracyclines and analogues thereof
发明人：MYERS ANDREW G; BRUBAKER JASON D; SUN CUIXIANG; WANG QIU
权利人:MYERS ANDREW G; BRUBAKER JASON D; SUN CUIXIANG; WANG QIU; HARVARD COLLEGE
摘要:The tetracycline class of antibiotics has played a major role in the treatment of infectious diseases for the past 50 years. However, the increased use of the tetracyclines in human and veterinary medicine has led to resistance among many organisms previously susceptible to tetracycline antibiotics. The modular synthesis of tetracyclines and tetracycline analogs described provides an efficient and enantioselective route to a variety of tetracycline analogs and polycyclines previously inaccessible via earlier tetra-cycline syntheses and semi-synthetic methods. These analogs may be used as anti-microbial agents or anti-pro liferative agents in the treatment of diseases of humans or other animals.

专利号:WO-2012088402-A1
优先权日:2010-12-22
标题 :Synthesis of conolidine and discovery of a potent non-opioid analgesic for pain
发明人：BOHN LAURA M; MICALIZIO GLENN C
权利人:SCRIPPS RESEARCH INST; BOHN LAURA M; MICALIZIO GLENN C
摘要:The first de novo synthetic pathway to the exceptionally rare C5-nor stemmadenine natural product, conolidine, and the first asymmetric synthesis of any member of this natural product class arc described. C5-nor stemmadenine compositions are also described. These compounds, for example,(+/- )-,(+)- and (-)-conolidine are potent and efficacious non-opioid analgesics in tonic and persistent pain.

专利号:US-7871794-B2
优先权日:2007-01-18
标 题:Enhanced cell-free synthesis of active proteins containing disulfide bonds
发明人：KNAPP KURTIS G; SWARTZ JAMES ROBERT
权利人:UNIV LELAND STANFORD JUNIOR
摘要:Compositions and methods are provided for the enhanced in vitro synthesis of active polypeptides containing disulfide bonds. In certain embodiments of the invention, the reaction mix includes a biological extract derived from a bacterial cell in which the glutathione reductase gene has been inactivated, which is pre-treated with a low concentration of a sulfhydryl inactivating agent.

专利号:US-6653087-B1
优先权日:1997-02-07
标 题 :Convergent synthesis of combinatorial library
发明人：BOGER DALE L
权利人:SCRIPPS RESEARCH INST
摘要:Targeted C2-symmetric and unsymmetric chemical libraries for use in protein and receptor homodimerization and heterodimerization are constructed by solution phase methodologies. Exemplary libraries are prepared in a 60 to 10 sub-library format by symmetrical coupling of the constructed fragments with a mixture of tethering dicarboxylic acids. In each step of the 3-step reaction sequence, the reactants, unreacted starting material, reagents and their byproducts were removed by simple liquid-liquid or liquid-solid extractions providing the desired intermediates and final libraries in multi-milligram quantities in high purities (≧90-100%) independent of the reaction yields and without deliberate reaction optimization. The synthesis of a second prototypical library employed the olefin metathesis reaction to join and combinatorially randomize the length of linker tether. This approach provides a unique opportunity to rapidly generate a statistically controlled mixture of homo and heterodimers of remarkable diversity.

专利号:US-7118627-B2
优先权日:2003-12-04
标 题 :Synthesis of colloidal PbS nanocrystals with size tunable NIR emission
发明人：HINES MARGARET A; SCHOLES GREGORY D
权利人:HINES MARGARET A; SCHOLES GREGORY D
摘要:The present invention discloses a method for synthesis of narrowly dipsersed colloidal PbS nanocrystals that offer size-tunable near-infrared emission. The stability and processibility of these near-infrared emitting quantum dots makes them ideal materials for device applications. The use of cost-effective and non-pyrophoric precursors as well as the success of larger scale reactions means the present invention provides a method for the industrial scale production of PbS nanocrystals.