CAS: 819-79-4; Diisopropylamine Hydrochloride

相似化合物

30321-74-5 132396-99-7 34636-09-4

上下游产品

piperidine hydr°Chloride N,N-diisopropyl-1-amino-2-(methylsulfonyl)-3-phenyl-2-propene P-(chloromethyl)-N,N,N',N'-tetraisopropylphosphonous diamide N-(pentafluorophenyl)carbonimidoyl dichlorideN,N-Diisopropyl-guanidinN,N-Diisopropyl-guanidin piperidine hydr°Chloride N,N-diisopropyl-1-amino-2-(methylsulfonyl)-3-phenyl-2-propene triisopropylamine

二异丙胺置于盐酸体系中,用 甲醇,水 作为反应溶剂,化学反应 2.0H,反应生成 盐酸二异丙胺
参考文献:二异丙基氯化铵半水合物晶体的晶体结构,希尔斯菲尔德表面分析和相变行为
标题:二异丙基氯化铵半水合物晶体的晶体结构,希尔斯菲尔德表面分析和相变行为
摘要:在100 K至503 K的温度范围内研究了很少研究的二异丙基氯化铵半水合物(dpc-Hh)的相稳定性.从甲醇溶液中生长的dpc-Hh单晶属于正交晶系,其空间群为ccca.环境温度(296 K),直到冷却至100 K时才显示出任何相变,而由于二异丙基氯化铵(dpc)和dpc-Hh晶格中水的客体性质,在室温下存储时其物理稳定性较差.当加热到室温以上时,发生水合物分子的脱水,这导致在空间群为p2 1的单斜晶体系统中无水dpc结晶.在342 K和439.7 K时,Dpc通过从单斜p2 1到p2 1 / M的可逆结构转变经历铁电到顺电相变.使用hirshfeld表面和指纹图来研究dpc-Hh的分子间相互作用.分子间的h⋯h接触是晶体中最重要的相互作用,占整个hirshfeld表面的72%以上.粉末x射线衍射,拉曼光谱和ft-Ir光谱,Tga和dsc技术被用来监测和确认dpc-Hh晶体的相稳定性,并且在dpc晶体系统中发生铁对位转变.
DOI:10.1016/j.Jpcs.2021.110008

专利信息

专利号:US-5512668-A
优先权日:1991-03-06
标 题 :Solid phase oligonucleotide synthesis using phospholane intermediates
发明人：STEC WOJCIECH J; GRAJKOWSKI ANDRZEJ; UZNANSKI BOGDAN
权利人:POLISH ACADEMY OF SCIENCES
摘要:Methods and compounds are provided for solid phase synthesis of oligonucleotides and related polymers by condensing protected monomer-O- 1,3,2-dichalcogen-substituted-phospholane! synthons in the presence of a catalytic base. Compounds of the invention include 2-N-substituted-1,3,2-dichalcogen-substituted-phospholane precursors of the above synthons, the protected monomer-O- 1,3,2-dichalcogen-substituted-phospholane! synthons, and P-chiral oligonucleotides and related P-chiral polymers.

专利号:WO-9714703-A1
优先权日:1995-10-16
标 题:Synthesis of polymerisable phosphodiesters
发明人：DRIVER MICHAEL JOHN; RUSSEL JEREMY COLIN; BROWNE JUDITH ELIZABETH; SAMMES PETER G
权利人:BIOCOMPATIBLES LTD; DRIVER MICHAEL JOHN; RUSSEL JEREMY COLIN; BROWNE JUDITH ELIZABETH; SAMMES PETER G
摘要:A mono- or di-functional phosphoramidite phosphitylating agent is used to phosphitylate an ethylenically unsaturated alcohol. The product may be oxidised to form the corresponding phosphate ester which may be reacted in further steps to form phosphoryl choline derivatives. The process is of value in the synthesis of 2-(Methacryloyloxyethyl)-2'-(trimethylammoniumethyl)phosphate, inner salt. It has the advantage over prior art processes in that the starting materials and intermediates are more stable and consequently easier to handle.

专利号:US-5646267-A
优先权日:1991-08-05
标 题:Method of making oligonucleotides and oligonucleotide analogs using phospholanes and enantiomerically resolved phospholane analogues
发明人：STEC WOJCIECH J; GRAJKOWSKI ANDRZEJ; UZNANSKI BOGDAN
权利人:POLISH ACADEMY OF SCIENCES
摘要:Methods and compounds are provided for solid phase synthesis of oligonucleotides and related polymers by condensing protected monomer-O-[1,3,2-dichalcogen-substituted-phospholane] synthons in the presence of a catalytic base. Compounds of the invention include 2-N-substituted-1,3,2-dichalcogen-substituted-phospholane precursors of the above synthons, the protected monomer-O-[1,3,2-dichalcogen-substituted-phospholane] synthons, and P-chiral oligonucleotides and related P-chiral polymers.

专利号:US-2024025939-A1
优先权日:2020-03-06
标 题:High sequence fidelity nucleic acid synthesis and assembly
发明人：POTTER ROBERT; NETUSCHIL NIKOLAI
权利人:LIFE TECHNOLOGIES CORP; THERMO FISHER SCIENT GENEART GMBH
摘要:The present disclosure generally relates to compositions and methods for the synthesis of nucleic acid molecules with low error rates. Provided, as examples, are compositions and methods for high throughput synthesis and assembly of nucleic acid molecules, in many instances, with high sequence fidelity. In many instances, thermostable mismatch recognition proteins (e.g., thermostable mismatch binding protein, thermostable mismatch endonucleases) will be present in compositions and use methods provided.

专利号:US-5883237-A
优先权日:1991-08-05
标 题:Oligonucleotides having Rp and Sp linkages at predetermined locations
发明人：STEC WOJCIECH J; GRAJKOWSKI ANDRZEJ; UZNANSKI BOGDAN
权利人:POLISH ACADEMY OF SCIENCE
摘要:Methods and compounds are provided for solid phase synthesis of oligonucleotides and related polymers by condensing protected monomer-O- 1,3,2-dichalcogen-substituted-phospholane! synthons in the presence of a catalytic base. Compounds of the invention include 2-N-substituted-1,3,2-dichalcogen-substituted-phospholane precursors of the above synthons, the protected monomer-O- 1,3,2-dichalcogen-substituted-phospholane! synthons, and P-chiral oligonucleotides and related P-chiral polymers.

专利号:WO-9816535-A1
优先权日:1996-10-16
标 题 :Synthesis of phosphorus compounds
发明人：DRIVER MICHAEL JOHN; WILMAN LAURA AINSLEY; JACKSON DEBORAH JANE
权利人:BIOCOMPATIBLES LTD; DRIVER MICHAEL JOHN; WILMAN LAURA AINSLEY; JACKSON DEBORAH JANE
摘要:A new phosphoramidite reagent has general formula (I) in which R12 is a C¿2-4? -alkylene, -alkenylene or -alkynylene group, which is unsubstituted or substituted by halogen atoms, hadroxyl, amine, alkyl or aryl groups or which is part of a fused ring, m is 2 or 3, the groups R?1¿ are the same or different and each represents branched or straight alkyl groups (including cycloalkyl) or, two of the groups or all three of the groups R1, together with the nitrogen atom to which they are attached, form a heterocyclic group optionally containing other heteroatoms and being saturated or unsaturated, provided that when m is 2 one of the groups R1 is joined to the nitrogen atom by a carbon-nitrogen double bond, and XÏ… is a counterion. The compound is preferably used to phosphitilate an alcohol, especially an ethylenically unsaturated polymerisable alcohol. The phosphorous triester is preferably oxidised and ring opened, preferably by a simultaneous amination reaction.