CAS: 82964-04-3; N-(6-Methoxy-5-(Trifluoromethyl)Naphthalene-1-Carbonothioyl)-N-Methylglycine

上下游产品

tolrestat methyl ester 6-methoxy-1-naphthalenecarboxylic acid methyl ester 5-Methyl-2-methoxy-1-(trifluoromethyl)naphthalene 6-methoxy-5-(trifluoromethyl)-1-naphthalenecarboxylic acid6-methoxy-5-(trifluoromethyl)-1-naphthalenecarboxylic acid 5-(Carboxymethyl-methyl-carbamoyl)-2-methoxy-naphthalene-1-carboxylic acid -thiomethyl-N-methylglycineN-(5-carboxyl)-6-methoxy-1-naphtalenyl-thiomethyl-N-methylglycine oxomethyl>-N-methylglycineN-6-methoxy-5-(trifluoromethyl)-1-naphthalenyloxomethyl-N-methylglycine

6-Methoxy-5-(Trifluoromethyl)-1-Naphthalenecarboxylic Acid Chloride置于氢氧化钾,Tetraphosphorus Decasulfide体系中,化学反应生成 托瑞司他
参考文献:N-[5-(三氟甲基)-6-甲氧基-1-萘基]硫代甲基]-N-甲基甘氨酸(tolrestat),一种有效的口服醛糖还原酶抑制剂.
标题:N-[5-(三氟甲基)-6-甲氧基-1-萘基]硫代甲基]-N-甲基甘氨酸(tolrestat),一种有效的口服醛糖还原酶抑制剂.
摘要:
DOI:10.1021/jm00369A003

专利信息

专利号:US-10005720-B2
优先权日:2013-04-05
标题:Compounds useful for the treatment of metabolic disorders and synthesis of the same
发明人：SEXTON JONATHAN Z; BRENMAN JAY E; MUSSO DAVID L
权利人:NORTH CAROLINA CENTRAL UNIV; UNIV NORTH CAROLINA CHAPEL HILL
摘要:The present invention provides compounds of Formula (I): wherein variables X, Y, Z and R1 are as described herein. Some of the compounds described herein are glutamate dehydrogenase activators. The invention is also directed to pharmaceutical compositions comprising these compounds, uses of these compounds and compositions in the treatment of metabolic disorders as well as synthesis of the compounds.

专利号:US-6495710-B2
优先权日:2000-01-14
标题:Synthesis and use of dimethyl 1,5-naphthalenedicarboxlyates and intermediates therefrom
发明人：MACEK JOHN A; ROSEN BRUCE I; HOLZHAUER JUERGEN K; BRAMLET JOHN S; LILLWITZ LARRY D; SCHNEIDER DAVID J; LANG LAWRENCE L; PASCHKE EDWARD E; WEIS JOHN M; VISWANATH YENAMANDRA; SAKELLARIDES STEFANOS L
权利人:BP CORP NORTH AMERICA INC
摘要:The synthesis of dimethyl-1,5-naphthalenedicarboxylate and polymers and articles formed therefrom is disclosed, as well as applications for dimethyl-1,5-naphthalenedicarboxylate, its corresponding acid 1,5-NDA, and various synthesis intermediates.

专利号:US-2005004225-A1
优先权日:2003-04-16
标题:Oxidoreductase inhibitors and methods of screening and using thereof
发明人：BALENDIRAN GANESARATNAM K
摘要:The present invention relates to 1) the design and synthesis of analogs to glutathione conjugates which bind to or interact with aldose reductase (AR) through unique conformations that are distinctly different from the substrates and inhibitors of AR which are members of sugar metabolism; 2) the screening of the analogs to identify those that interact with or inhibit or enhance the activity of AR; and 3) the use of AR ligands, AR inhibitors (AR antagonsits) or AR enhancer (AR agonists) in the detection of AR activity, the modulation of AR activity, and the treatment of conditions in a subject in need of modulating AR activity. Such conditions include but not limited to cardiovascular disease, diabetes, artheriosclerosis, cancer, neoplasm, obesity, cataract, retinopathy, keratopathy, nephropathy, neurosis, thrombosis, faulty union of corneal injury and neuropathy. Examples of the treatment include the use of fibrates as AR inhibitors to treat these conditions.

专利号:US-2025223262-A1
优先权日:2022-03-31
标 题 :Synthesis of morphinans with reduced herg activity and mop binding
发明人：LAMMERT ECKHARD; SCHOLZ OKKA; OTTER SILKE; HEREBIAN DIRAN; HOFFMANN TORSTEN; SANZ MIGUEL ANGEL; KRAMP LAURENZ; LEVY LAURA MARIANA; HRISTEVA STANIMIRA
权利人:HEINRICH HEINE UNIV DUESSELDORF; DEUTSCHE DIABETES FORSCHUNGSGESELLSCHAFT E V; TAROS CHEMICALS GMBH & CO KG
摘要:The invention relates to morphinan-derivatives, processes for their preparation, medicaments containing them and the use of these morphinan-derivatives for the preparation of medicaments.

专利号:US-2018370905-A1
优先权日:2013-04-05
标题:Compounds Useful for the Treatment of Metabolic Disorders and Synthesis of the Same

专利号:US-9018249-B2
优先权日:2011-09-13
标题 :SGLT inhibitors
发明人：JAIN RAJESH; TREHAN SANJAY; DAS JAGATTARAN; NANDA GURMEET KAUR; THUNGATHURTHI SASTRY V R S; SINGH NISHAN; SHARMA SUDHIR KUMAR
权利人:JAIN RAJESH; TREHAN SANJAY; DAS JAGATTARAN; NANDA GURMEET KAUR; THUNGATHURTHI SASTRY V R S; SINGH NISHAN; SHARMA SUDHIR KUMAR; PANACEA BIOTEC LTD
摘要:The present invention relates to novel compounds of Formula I, their pharmaceutically acceptable derivatives, tautomeric forms, isomers, polymorphs, prodrugs, metabolites, salts or solvates thereof. The invention also relates to the processes for the synthesis of novel compounds of Formula I, their pharmaceutically acceptable derivatives, tautomeric forms, isomers, polymorphs, prodrugs, metabolites, salts or solvates thereof. The present invention also provides pharmaceutical compositions comprising novel compounds of Formula I and methods of treating or preventing one or more conditions or diseases that may be regulated or normalized via inhibition of Sodium Glucose Cotransporter-2 (SGLT-2).