CAS: 1593-08-4; Quinoxaline-2-Carbaldehyde

该化合物是一种有机化合物,其特征是五氧基结构,由含有两个氮原子的双环系统组成.该化合物的特征是附于五氧基环的甲酰胺功能组(CHO),有助于其活性及有机合成的潜在应用.该物质在室内温度下通常是黄到褐的固体,在乙醇和二氯甲烷等有机溶剂中可溶解.甲醛基甲胺组的存在使其在合成各种药品和农用化学品时成为多用途中间体.此外,2-五氧基甲巴丁可参与凝聚反应,从而形成更复杂的分子结构.其独特的结构和功能特性使其对医药化学和材料科学感兴趣.安全数据表明,与许多有机化合物一样,它应该谨慎处理,因为吸入或浸入甲胺可能会对健康造成危害.在与该物质打交道时,应该遵循适当的实验室做法和安全议定书.

结构式图片

相似化合物

879-65-2 1865-11-8 41242-94-8

欧盟法规

ECHA物质C&L通报

上下游产品

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合成工艺路线路线简述

    (1R,2S,3R)-(2-喹喔啉基)-1,2,3,4-丁烷四醇置于sodium Periodate体系中,用 水 用作溶剂,化学反应 0.05H,以56%的收率获得2-喹喔啉甲醛
    参考文献:微波氧化去除杂环烷基或糖侧链:生成黄蝶呤,6-甲酰蝶呤和 3-羟甲基-2(1H)-喹喔啉酮的简单步骤
    标题:微波氧化去除杂环烷基或糖侧链:生成黄蝶呤,6-甲酰蝶呤和 3-羟甲基-2(1H)-喹喔啉酮的简单步骤
    摘要:分别用二氧化硒和高碘酸钠一步微波辅助氧化去除 2(1H)-喹喔啉酮体系中的 3-甲基和 3-糖侧链,得到 2(1H)-喹喔啉酮...
    Doi:10.1246/cl.2007.1118

    海关参考信息

    专利信息


    专利号:WO-2015109451-A1
    优先权日:2014-01-22
    标 题 :Synthesis of compounds containing 8-oxa-3-azabicyclo (3.2.1)octane ring
    发明人:LI PENG; DECAMPO FLORYAN; SHI FENG; CUI XINJIANG; YUAN HANGKONG
    权利人:RHODIA OPERATIONS; LANZHOU INSTITUTION OF CHEMICAL PHYSICS CHINESE ACADEMY OF SCIENCE
    摘要:The present invention mainly pertains to catalytic processes for the direct amination of 2, -bis(hydroxymethyl) tetrahydrofuran to obtain compounds containing the 8-oxa-3-azabicyclo (3.2.1) octane ring, in the presence of: a homogenous catalyst which is a complex comprising at least one element selected from the group consisting of Iridium or Ruthenium and at least one donor ligand, or a heterogeneous catalyst comprising at least one Group 8-11 transition metal element and one poor metal element in the p-block of the period table.

    专利号:US-8378099-B2
    优先权日:1994-10-28
    标 题:Boronic ester and acid compounds, synthesis and uses
    发明人:ADAMS JULIAN; MA YU-TING; STEIN ROSS L; BAEVSKY MATTHEW; GRENIER LOUIS; PLAMONDON LOUIS
    权利人:MILLENNIUM PHARMACUETICALS INC; ADAMS JULIAN; STEIN ROSS L; BAEVSKY MATTHEW; GRENIER LOUIS; PLAMONDON LOUIS
    摘要:Disclosed herein is a method for reducing the rate of degradation of proteins in an animal, comprising contacting cells of the animal with certain boronic ester and acid compounds. Also disclosed herein are novel boronic ester and acid compounds, their synthesis and uses.

    专利号:US-7612106-B2
    优先权日:2004-12-23
    标题 :Fused pyrazole derivatives and methods of treatment of metabolic-related disorders thereof
    发明人:BOATMAN P DOUGLAS; SCHRADER THOMAS O; SEMPLE GRAEME; SKINNER PHILIP J; JUNG JAE-KYU
    权利人:ARENA PHARM INC
    摘要:The present invention relates to certain fused pyrazole derivatives of Formula (Ia), and pharmaceutically acceptable salts thereof, which exhibit useful pharmacological properties, for example, as agonists for the RUP25 receptor. n nAlso provided by the present invention are pharmaceutical compositions containing compounds of the invention, and methods of using the compounds and compositions of the invention in the treatment of metabolic-related disorders, including dyslipidemia, atherosclerosis, coronary heart disease, insulin resistance, type 2 diabetes, Syndrome-X and the like. In addition, the present invention also provides for the use of the compounds of the invention in combination with other active agents such as those belonging to the class of α-glucosidase inhibitors, aldose reductase inhibitors, biguanides, HMG-CoA reductase inhibitors, squalene synthesis inhibitors, fibrates, LDL catabolism enhancers, angiotensin converting enzyme (ACE) inhibitors, insulin secretion enhancers, DP receptor antagonists, and the like.

    专利号:US-4702744-A
    优先权日:1985-06-13
    标题:Process for the preparation of concentrated solutions of anionic dyestuffs and dyestuff additives by cation exchange with cation exchange resin
    发明人:WOLFF JOACHIM; KOLL JOCHEN; WOLF KARLHEINZ; KLIPPER REINHOLD M; LANGE PETER M
    权利人:BAYER AG
    摘要:Stable, concentrated aqueous solutions of, in particular, anionic reactive dyestuffs are obtained in a comparatively simple manner by freeing from salts, preferably by means of membrane separation processes, solutions of these substances just as they are obtained in the course of synthesis, and by replacing, with the aid of ion exchangers, the cations which cause sparing solubility.

    专利号:WO-2021030238-A2
    优先权日:2019-08-09
    标题:Method of synthesis of compound for dual inhibition of jak2 and bet

    专利号:CN-113831330-A
    优先权日:2021-09-08
    标题:A new method for three-step synthesis of drug molecule 3-(2-thiophene-2-methylene)hydrazinoquinoxalin-2-one
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    合成参考文献


    摘要:Tymoshenko, D. O., Science of Synthesis Knowledge Updates, (2012) 3, 394.
    摘要:Tymoshenko, D. O., Science of Synthesis Knowledge Updates, (2012) 3, 388.
    摘要:Tymoshenko, D. O., Science of Synthesis Knowledge Updates, (2012) 3, 396.
    摘要:Saikawa, Y.; Nakata, M., Science of Synthesis Knowledge Updates, (2018) 3, 367.
    参考文献:10.1107/s160053681002893x
    摘要:Suthiram J, Zeevaart JR, Visser HG, Roodt A. Tetraethylammonium tricarbonylchlorido(quinoxaline-2-carboxylato-κ2N1,O)rhenate(I). Acta Crystallogr E Struct Rep Online. 2010 Jul 31;66(8):m1042–3. doi: 10.1107/s160053681002893x.
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