专利号:WO-2015109451-A1 优先权日:2014-01-22 标 题 :Synthesis of compounds containing 8-oxa-3-azabicyclo (3.2.1)octane ring 发明人:LI PENG; DECAMPO FLORYAN; SHI FENG; CUI XINJIANG; YUAN HANGKONG 权利人:RHODIA OPERATIONS; LANZHOU INSTITUTION OF CHEMICAL PHYSICS CHINESE ACADEMY OF SCIENCE 摘要:The present invention mainly pertains to catalytic processes for the direct amination of 2, -bis(hydroxymethyl) tetrahydrofuran to obtain compounds containing the 8-oxa-3-azabicyclo (3.2.1) octane ring, in the presence of: a homogenous catalyst which is a complex comprising at least one element selected from the group consisting of Iridium or Ruthenium and at least one donor ligand, or a heterogeneous catalyst comprising at least one Group 8-11 transition metal element and one poor metal element in the p-block of the period table.
专利号:US-8378099-B2 优先权日:1994-10-28 标 题:Boronic ester and acid compounds, synthesis and uses 发明人:ADAMS JULIAN; MA YU-TING; STEIN ROSS L; BAEVSKY MATTHEW; GRENIER LOUIS; PLAMONDON LOUIS 权利人:MILLENNIUM PHARMACUETICALS INC; ADAMS JULIAN; STEIN ROSS L; BAEVSKY MATTHEW; GRENIER LOUIS; PLAMONDON LOUIS 摘要:Disclosed herein is a method for reducing the rate of degradation of proteins in an animal, comprising contacting cells of the animal with certain boronic ester and acid compounds. Also disclosed herein are novel boronic ester and acid compounds, their synthesis and uses.
专利号:US-7612106-B2 优先权日:2004-12-23 标题 :Fused pyrazole derivatives and methods of treatment of metabolic-related disorders thereof 发明人:BOATMAN P DOUGLAS; SCHRADER THOMAS O; SEMPLE GRAEME; SKINNER PHILIP J; JUNG JAE-KYU 权利人:ARENA PHARM INC 摘要:The present invention relates to certain fused pyrazole derivatives of Formula (Ia), and pharmaceutically acceptable salts thereof, which exhibit useful pharmacological properties, for example, as agonists for the RUP25 receptor. n nAlso provided by the present invention are pharmaceutical compositions containing compounds of the invention, and methods of using the compounds and compositions of the invention in the treatment of metabolic-related disorders, including dyslipidemia, atherosclerosis, coronary heart disease, insulin resistance, type 2 diabetes, Syndrome-X and the like. In addition, the present invention also provides for the use of the compounds of the invention in combination with other active agents such as those belonging to the class of α-glucosidase inhibitors, aldose reductase inhibitors, biguanides, HMG-CoA reductase inhibitors, squalene synthesis inhibitors, fibrates, LDL catabolism enhancers, angiotensin converting enzyme (ACE) inhibitors, insulin secretion enhancers, DP receptor antagonists, and the like.
专利号:US-4702744-A 优先权日:1985-06-13 标题:Process for the preparation of concentrated solutions of anionic dyestuffs and dyestuff additives by cation exchange with cation exchange resin 发明人:WOLFF JOACHIM; KOLL JOCHEN; WOLF KARLHEINZ; KLIPPER REINHOLD M; LANGE PETER M 权利人:BAYER AG 摘要:Stable, concentrated aqueous solutions of, in particular, anionic reactive dyestuffs are obtained in a comparatively simple manner by freeing from salts, preferably by means of membrane separation processes, solutions of these substances just as they are obtained in the course of synthesis, and by replacing, with the aid of ion exchangers, the cations which cause sparing solubility.
专利号:WO-2021030238-A2 优先权日:2019-08-09 标题:Method of synthesis of compound for dual inhibition of jak2 and bet
专利号:CN-113831330-A 优先权日:2021-09-08 标题:A new method for three-step synthesis of drug molecule 3-(2-thiophene-2-methylene)hydrazinoquinoxalin-2-one