CAS: 17745-45-8; Propylboronic Acid

该化合物是一种有机有机体化合物,其特征是:有柱状原子结结为丙基和氢氧基组,这种化合物一般看起来无色可粉黄黄色液体或固体,因其形态和纯度不同,在有机合成中是有用的,特别是在铃木混合反应中,它充当形成碳质联结的灵敏试剂.它在水和酒精等极溶剂中表现出中等溶解性,而在非极溶剂中则不易溶解.由于存在碱性酸功能组,它能够形成可逆转的二醇复合体,因此在包括药物开发和材料科学在内的各种应用中有用.此外,其再活性还可能受到附于原子的子组成者的电子和胃特性的影响,因为可针对特定的合成路径进行调整.在处理这一化合物时,应当采取安全防范措施,因为许多有机子化合物具有毒性和潜在性.

结构式图片

相似化合物

67562-19-0 897067-94-6 4426-47-5

欧盟法规

C&L通报

上下游产品

CAS号121-43-7 硼酸三甲酯 | CAS号927-77-5 丙基溴化镁 | CAS号1116-61-6 Tri-N-Propylboron | CAS号68498-84-0 boric acid-carbon | CAS号1739-52-2 3,3-dichloropro... | CAS号108-20-3 异丙醚 | CAS号7732-18-5 水 | CAS号41453-14-9 2-Aminopyridin | CAS号18113-79-6 5-甲基-2-丙基-吡啶 | CAS号2440-40-6 chloro(propyl)m... | CAS号121-43-7 硼酸三甲酯 | CAS号2938-87-6 dimethoxy(propy... | CAS号540-54-5 1-氯丙烷 | CAS号11113-50-1 硼酸 | CAS号10342-59-3 1-硝基-4-正-丙基苯 | CAS号2932-65-2 4-正丙基苯乙酮

合成工艺路线路线简述

  • 合成目标产物 Propylboronic Acid 主要起始原料 Trimethyl Borate And N-Propylmagnesium Bromide
  • (文献来源)合成步骤主要原料 Trimethyl Borate 和 N-Propylmagnesium Bromide
三丙基硼烷 反应生成正丙基硼酸
参考文献:Krause; Nitsche,Chemische Berichte,1921,Vol. 54,P. 2789
标题:Krause; Nitsche,Chemische Berichte,1921,Vol. 54,P. 2789

海关参考信息

专利信息


专利号:WO-2022192582-A1
优先权日:2021-03-10
标 题 :Methods of synthesizing halogenated cannabinoids and derivatives of cannabinoids
发明人:DAVIS ROBERT; BLACK JACOB; SMELTZER THOMAS; COLVIN SEAN
权利人:TREEHOUSE BIOSCIENCES INC
摘要:The technology described herein provides for the synthesis of various cannabinoids, cannabinoid derivatives, and intermediate molecules useful in the synthesis of cannabinoids. For example, the technology described herein provides methods for synthesis of cannabinoids halogenated at the 4-position.

专利号:US-2009099218-A1
优先权日:2007-09-17
标题 :Synthesis of novel tubulin polymerization inhibitors: benzoylphenylurea (bpu) sulfur analogs
发明人:KHAN SAEED R; HALLUR GURULINGAPPA; HIDALGO MANUEL; JIMENO ANTONIO
权利人:KHAN SAEED R; HALLUR GURULINGAPPA; HIDALGO MANUEL; JIMENO ANTONIO
摘要:This invention provides a series of BPU analogues; their synthesis and evaluated biological activity. BPU sulfur analogues were found to possess up to 20 fold increased potency, when compared to compound 1, in various cancerous cell lines.

专利号:US-7595326-B2
优先权日:2005-04-18
标题 :Synthesis of novel tubulin polymerization inhibitors: benzoylphenylurea (BPU) sulfur analogs
发明人:KHAN SAEED R; HALLUR GURULINSAPPA; HIDALGO MANUEL; JIMENO ANTONIO
权利人:CHAMPIONS BIOTECHNOLOGY INC
摘要:A novel series of BPU analogues were synthesized and evaluated for antitumor activity. In particular, BPU sulfur analogues 6 n and 7 d were shown to possess up to 10-fold increased potency, when compared to compound 1, against cancer cell lines. 6 n was more effective than compound 1 in causing apoptosis of MCF-7 cells. When compared to other drugs with a similar mechanism of action, 6 n retained significant ability to inhibit tubulin assembly, with an IC 50 of 2.1 μM.

专利号:US-8207337-B2
优先权日:2007-01-29
标 题:Reagent for organic synthesis reaction containing organic triol borate salt
发明人:MIYAURA NORIO; YAMAMOTO YASUNORI
权利人:MIYAURA NORIO; YAMAMOTO YASUNORI; WAKO PURE CHEM IND LTD
摘要:[Problem] n To provide an organoboron compound-containing reagent for organic synthesis reactions which undergoes no trimerization with dehydration, does not necessitate activation with a base, and is stable and highly active. n [Means for Solving Problems] n The reagent for organic synthesis reactions contains an organic triol borate salt represented by any of the general formulae (I) to (III) and general formula (XVI): (wherein R 1 represents alkyl, alkenyl, etc.; R 2 represents optionally substituted alkyl, alkenyl, alkynyl, etc. or represents hydrogen; m + represents an alkaline metal ion, phosphonium ion, or given ammonium ion; M 2+ represents an alkaline earth metal; X represents halogen or alkoxide; Y represents an alkali metal ion, etc.; A represents optionally substituted methylene; and n represents an integer).

专利号:US-9920056-B2
优先权日:2015-06-16
标题:2-oxo-1,3,8-triazaspiro[4.5]decan-3-yl] carboxylic acid derivatives
发明人:BEAUCHAMP THOMAS JAMES; COATES DAVID ANDREW; MARTINEZ-GRAU MARIA ANGELES; TOLEDO MIGUEL ANGEL
权利人:LILLY CO ELI
摘要:The present invention provides compounds of Formula 1, n nwhere A is selected fromn n nand R1, R2 and R3 are defined in the specification, or a pharmaceutically acceptable salt thereof, methods of using the compounds to treat diabetes, and processes for the synthesis of the compounds.

专利号:US-2007232631-A1
优先权日:2005-04-18
标 题 :Design and synthesis of novel tubulin polymerization inhibitors: benzoylphenylurea (bpu) sulfur analogs
北京普瑞东方化学技术有限公司
⚠️ 未注册 · 未认证企业
⚠️ 该商家尚未完成注册及企业认证,请用户仔细辨别,谨慎交易。
数据来源于公开网络搜索,平台未作核实,请自行辨别。
🏢敬请 企业认领
🏬开设公司展台
📢获取免费会员权益
🎖️点亮专属注册企业标签
📇展现公司完整信息 样本查看立即注册认领 →
网址: http://www.bjpurechem.com
企业联系电话:010-83993285👤
📞北京普瑞东方化学技术有限公司 ⚠️参考联系方式
联系人:冷先生
电话:010-83993285
手机:17610176018
传真:010-63370219
邮箱:sales@bjpurechem.com
通信地址: 北京市海淀区西三环北路50号院6号楼豪柏大厦1708室
邮编: 100048
🆔 联系时候可告知是从"百琢研"平台获取的信息.
⚠️ 声明: 该企业未认证、未认领,请自行辨别信息的真实性和可靠性。咨询或交易时请注意风险评估与信息核实,百琢研不参与任何交易。企业认领注册入口→

地址:北京市海淀区西三环北路50号院6号楼豪柏大厦1708室
⚠️ 未注册 · 未认证企业
注册入口 备注: 📌 数据来源说明:本展台内容基于各搜索引擎等公开数据整理,仅作展示用途。请用户自行辨别
✉️ 若企业需抹除展台内容或有异议, 请通过页面底部联系方式告知我们,我们会尽快处理。
鞍钢实业三块石化工厂
⚠️ 未注册 · 未认证企业
⚠️ 该商家尚未完成注册及企业认证,请用户仔细辨别,谨慎交易。
数据来源于公开网络搜索,平台未作核实,请自行辨别。
🏢敬请 企业认领
🏬开设公司展台
📢获取免费会员权益
🎖️点亮专属注册企业标签
📇展现公司完整信息 样本查看立即注册认领 →
网址: http://www.3stoneschem.com
电话: 0412-2461070 2461278👤
📞鞍钢实业三块石化工厂 ⚠️参考联系方式

销售电话:0412-2461070 2461278
邮箱:yangbc@3stoneschem.com
🆔 联系时候可告知是从"百琢研"平台获取的信息.
⚠️ 声明: 该企业未认证、未认领,请自行辨别信息的真实性和可靠性。咨询或交易时请注意风险评估与信息核实,百琢研不参与任何交易。企业认领注册入口→

⚠️ 未注册 · 未认证企业
注册入口 备注: 📌 数据来源说明:本展台内容基于各搜索引擎等公开数据整理,仅作展示用途。请用户自行辨别 ✉️ 若企业需抹除展台内容或有异议, 请通过页面底部联系方式告知我们,我们会尽快处理。
第 1 / 1 页
现货

供应商参考报价(招募中)

品牌试剂参考报价(招募中)

📌 第三方产品分析报告

✅ COA系统入驻 | 共享模式

主要参考文献

[参考文献]: Kenneth D Clevenger, Et Al. N-Alkylboronic Acid Inhibitors Reveal Determinants Of Ligand Specificity In The Quorum-Quenching And Siderophore Biosynthetic Enzyme Pvdq. Biochemistry. 2014 Oct 28;53(42):6679-86.

合成参考文献


摘要:Weibel, J.-M.; Blanc, A.; Pale, P., Science of Synthesis Knowledge Updates, (2018) 1, 84.
摘要:Liang, Y.; Wen, Z.; Cabrera, M.; Howlader, A. H.; Wnuk, S. F., Science of Synthesis Knowledge Updates, (2020) 1, 216.
📝 需求与反馈
尽可能描述清楚需求与问题信息
×

通知