CAS: 2182-14-1; Vindoline

上下游产品

CAS号867214-27-5 methyl (2S,3aR,... | CAS号108-24-7 乙酸酐 | CAS号3633-92-9 Deacetylvindoline | CAS号202807-44-1 6-甲氧基-1-甲基-1H-吲... | CAS号1968-17-8 6-methoxy-1-met... | CAS号64954-92-3 N1-methyl-6-met... | CAS号867214-12-8 N-(2-(6-methoxy... | CAS号867214-10-6 N-(2-(6-methoxy... | CAS号3633-92-9 Deacetylvindoline | CAS号38390-45-3 脱水长春碱 | CAS号363623-08-9 (S)-tert-Butyl ... | CAS号23360-92-1 长春罗新

Ervamycine; 11-甲氧基水甘草碱置于acetate Buffer Ph 4.2,W-2 Raney Ni,苯亚硒酸酐,Sodium Acetate,Sodium Cyanoborohydride,Potassium Carbonate,间氯过氧苯甲酸体系中,用 甲醇,二氯甲烷,水,苯 用作溶剂,化学反应生成文多灵
参考文献:快速获取高度氧化的曲霉精生物碱长春花碱,长春花碱和长春花碱
标题:快速获取高度氧化的曲霉精生物碱长春花碱,长春花碱和长春花碱
摘要:据报道,通过迄今未知的氮杂二烯(3A,B),一种高度方便有效的合成长春新碱(1A)和长春新碱(1B)的方法.
Doi:10.1039/c39840000909

专利信息

专利号:US-7420052-B2
优先权日:2001-08-24
标 题:Intermediates for synthesis of vinblastine, process for preparation of the intermediates and process for synthesis of vinblastines
发明人：FUKUYAMA TOHRU; TOKUYAMA HIDETOSHI; YOKOSHIMA SATOSHI
权利人:JAPAN SCIENCE & TECH AGENCY
摘要:An intermediate for vinblastine synthesis represented by general formula A. n ngeneral formula A.n n(in the formula, R 1 , R 2 , R 3 and R 4 are the group selected independently from the group consisting of H, lower alkyl group, lower alkoxy group, halogen, lower perfluoroalkyl group, lower alkylthio group, hydroxy group, amino group, mono- or di-alkyl or acylamino group, lower alkyl or arylsulfonyloxy group. R 5 is H, or a lower alkyl group or a substituted or non-substituted aryl group, R 6 is an alkyl group of carbon number 4 or less, R 7 is a substituted or non-substituted aryl group, R 8 is a substituted or non-substituted aryl group or lower alkyl group and R 9 is an acyl group or trialkylsilyl group.) A method for synthesis of the compound of general formula A utilizing radical ring forming reaction of thioanilides and using the compound of general formula B as the starting material, synthesizing thioanilide of general formula C by the reaction with compound 1 and the formation of a 11-membered ring by intramolecular alkylation of 2-nitrobenzenesulfonamide by which the reactions can proceed under mild conditions and high yield can be accomplished.

专利号:US-5220016-A
优先权日:1991-07-29
标 题:Synthesis of navelbine analogs
发明人：MAGNUS PHILIP D; THURSTON LEE S
权利人:UNIV TEXAS
摘要:The invention is a de novo synthesis of the norcatharanthine moiety of navelbine. The synthesis includes condensing a Grignard reagent prepared from an amine-protected R(+)-piperidinyl methanol with an N-protected 2-methoxyoxalyl indole. The indole N-protecting group is removed to provide a 2-methoxyindole hydroxy ester which is coupled to vindoline. After removal of the amineprotecting group from the piperidinyl group, ring closure to the indole moiety provides dihydrodesethyl navelbine. Other derivatives and analogs of navelbine with potential clinical applications in cancer chemotherapy may be readily synthesized. The synthesis opens a route to a wide variety of navelbine modifications, including modifications at or near the tryptamine bridge.

专利号:US-4841045-A
优先权日:1985-03-12
标 题 :Synthesis of vinblastine and vincristine type compounds
发明人：KUEHNE MARTIN
权利人:UNIV VERMONT
摘要:A new process for the stereospecific synthesis of alkaloids of the vinblastine and vincristine type including the synthesis of vinblastine and vincristine as well novel alkaloids which are active as anti-tumor agents.

专利号:US-4897477-A
优先权日:1985-03-12
标题:Synthesis of vinblastine and vincristine type compounds
发明人：KUEHNE MARTIN
权利人:UNIV VERMONT
摘要:A new process for the stereospecific synthesis of alkaloids of the vinblastine and vincristine type including the synthesis of vinblastine and vincristine as well novel alkaloids which are active as anti-tumor agents.

专利号:US-RE37449-E
优先权日:1987-02-06
标题:Process of synthesis of 3′,4′-anhydrovinblastine, vinblastine and vincristine
发明人：KUTNEY JAMES P; CHOI LEWIS S L; NAKANO JUN; TSUKAMOTO HIROKI; BOULET CAMILLE A; MCHUGH MICHAEL
权利人:UNIV BRITISH COLUMBIA
摘要:The present invention relates to the synthesis of dimer alkaloid compounds, particularly those of the Catharantus (Vinca) family, from an indole unit, such as cantharanthine, and a dihydroindole unit, such as vindoline. A multi-step process is disclosed including the steps of (1) of 1,4-reduction of a first dimeric iminium intermediate to an enamine compound by reaction with a 1,4-dihydropyridine compound; (2) oxidative transformation of the resulting enamine to a second iminium intermediate under controlled aeration; (3) reduction of the second iminium intermediate to form the target dimer alkaloid compounds. The entire process can be conducted in a one-pot operation to obtain the target compounds without isolation of the intermediates.

专利号:US-6818777-B2
优先权日:2000-12-07
标 题:Intermediates for synthesis of vinblastine compound and method for synthesizing the intermediate
发明人：FUKUYAMA TOHRU; TOKUYAMA HIDETOSHI
权利人:JAPAN SCIENCE & TECH AGENCY
摘要:Intermediates A, which are important in the whole synthesis of vindoline; and a method of synthesizing intermediates respectively represented by the general formulae B and C. By the method, the target intermediates are effectively synthesized with satisfactory reproducibility. This synthesis method is especially suitable for mass production. General formula A General formula B General formula C.