CAS: 287714-35-6; Methyl 2-Chloropyrimidine-5-Carboxylate

相似化合物

374068-01-6 1046816-75-4 933702-55-7

上下游产品

CAS号308348-93-8 2-氨基吡啶-5-羧酸甲酯 | CAS号110100-09-9 2-(2-氯嘧啶-5-基)丙烷-2-醇 | CAS号1046816-75-4 (2-氯嘧啶-5-基)甲醇 | CAS号38275-41-1 2-巯甲基嘧啶-5-羧酸甲酯 | CAS号928713-22-8 2-(3-chlorophen... | CAS号38373-46-5 2-甲氧基嘧啶-5-羧酸甲酯

2-氨基吡啶-5-羧酸甲酯置于盐酸,Zinc(II) Chloride,Sodium Nitrite体系中,用 二氯甲烷 用作溶剂,化学反应 2.5H,以44.4%的收率获得2-氯嘧啶-5-羧酸甲酯
参考文献:Combination Therapy With A Phosphoinositide 3-Kinase Inhibitor With A Zinc Binding Moiety
标题:Combination Therapy With A Phosphoinositide 3-Kinase Inhibitor With A Zinc Binding Moiety
摘要:该发明提供了一种治疗需要的受试者癌症的方法,包括向受试者施用: (A) Formula I的化合物: 或其药学上可接受的盐,其中r为氢或酰基;和(b)pd-1信号抑制剂;其中formula I的化合物或其药学上可接受的盐和pd-1信号抑制剂以联合治疗有效的剂量给予.该发明还提供了一种包括formula I的化合物或其药学上可接受的盐,Pd-1信号抑制剂和药学上可接受的载体或赋形剂的药物组合物.

专利信息

专利号:US-2011124867-A1
优先权日:2007-12-18
标题 :Process and intermediates for the Synthesis of heterocyclic Substituted Piperazines with CXCR3 Antagonist Activity
发明人：CHEN FRANK XING; CUTARELLI TIMOTHY D; FU XIAYONG; LIANG XIAN; MCALLISTER TIMOTHY L; ORR ROBERT K; YIN JIANGUO; YONG KELVIN H; ZHU MAN
权利人:SCHERING CORP
摘要:The present invention relates to novel processes for the preparation of the compound of the Formula A45: n n n n n n n n n n or a physiologically acceptable salt, solvate or prodrug thereof, which has utility, for example, as a pharmaceutically active compound with CXCR3 antagonist activity, and to novel intermediates useful in the synthesis thereof.

专利号:US-2010120784-A1
优先权日:2007-04-20
标题 :Novel heteroaromatic compounds as inhibitors of stearoyl-coenzyme a delta-9 desaturase
发明人：LACHANCE NICOLAS; LI CHUN SING; LECLERC JEAN-PHILPPE; RAMTOHUL YEEMAN K
权利人:LACHANCE NICOLAS; LI CHUN SING; LECLERC JEAN-PHILPPE; RAMTOHUL YEEMAN K
摘要:Heteroaromatic compounds of structural formula (I) or a pharmaceutically acceptable salt thereof, wherein W is a substituted heteroaryl, X and Y are each independently a bond, —O—, —S—, —S(O)—, —S(O) 2 —, —NR 6 —, —C(O)—, —C(CH 3 )(OH)— or —C(CH 3 )â•?CH—, u (I) is an integer from 1 to 4, and Ar is an optionally substituted phenyl or naphtyl, are inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD) The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease, such as atherosclerosis, obesity, Type 2 diabetes, insulin resistance, hyperglycemia, Metabolic Syndrome, neurological disease, cancer, and liver steatosis

专利号:US-2011183958-A1
优先权日:2008-10-17
标 题 :Azetidine derivatives as inhibitors of stearoyl-coenzyme a delta-9 desaturase
发明人：POWELL DAVID; TRANMER GEOFFREY K
权利人:MERCK FROSST CANADA LTD
摘要:Azetidine derivatives of structural formula I are inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD). The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease; atherosclerosis; obesity; diabetes; neurological disease; Metabolic Syndrome; insulin resistance; cancer; liver steatosis; and non-alcoholic steatohepatitis.

专利号:US-7582633-B2
优先权日:2007-01-26
标题:Azacycloalkane derivatives as inhibitors of stearoyl-coenzyme a delta-9 desaturase
发明人：LEBLANC YVES; POWELL DAVID; RAMTOHUL YEEMAN K; LEGER SERGE
权利人:MERCK FROSST CANADA L L C
摘要:Azacycloalkane derivatives of structural formula I are selective inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD1) relative to other known stearoyl-coenzyme A desaturases. The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease, such as atherosclerosis; obesity; diabetes; neurological disease; metabolic syndrome; insulin resistance; and liver steatosis.

专利号:US-9751895-B2
优先权日:2015-09-24
标 题:N-[2-(2-amino-6,6-disubstituted-4,4a,5,6-tetrahydropyrano[3,4-d][1,3]thiazin-8a(8H)-yl)-1,3-thiazol-4-yl]amides
发明人：BRODNEY MICHAEL AARON; BUTLER CHRISTOPHER RYAN; ZHANG LEI; O'NEILL BRIAN THOMAS; VERHOEST PATRICK ROBERT; MIKOCHIK PETER JUSTIN; MURRAY JOHN CHARLES; HOU XINJUN
权利人:PFIZER
摘要:The present invention is directed to compounds, tautomers and pharmaceutically acceptable salts of the compounds which are disclosed, wherein the compounds have the structure of Formula I, n nand the variables R 1 , R 2 and R 3 are as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

专利号:US-9611264-B1
优先权日:2015-09-24
标 题:N-[2-(3-amino-2,5-dimethyl-1,1-dioxido-5,6-dihydro-2H-1,2,4-thiadiazin-5-yl)-1,3-thiazol-4-yl] amides
发明人：BRODNEY MICHAEL AARON; BUTLER CHRISTOPHER RYAN; ZHANG LEI; O'NEILL BRIAN THOMAS; VERHOEST PATRICK ROBERT; SALOMON FERRER ROMELIA DEL CARMEN
权利人:PFIZER
摘要:The present invention is directed to compounds, tautomers and pharmaceutically acceptable salts of the compounds which are disclosed, wherein the compounds have the structure of Formula I, n n n n n n n n n n n n wherein the variables R 1 , R 2 and R 3 are as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.