CAS: 3217-15-0; 4-Bromo-2,6-Dichlorophenol

上下游产品

2,6-二氯苯酚 2,6-Dichlorophenol 87-65-0

4-溴苯酚置于二氧化碳,氯,溶剂黄146体系中,化学反应生成 4-溴-2,6-二氯酚
参考文献:Odor Identification Impairments In Schizophrenia: Relationship With Demographic Measures,Clinical Variables,And Diagnostic Subtypes
标题:Odor Identification Impairments In Schizophrenia: Relationship With Demographic Measures,Clinical Variables,And Diagnostic Subtypes
摘要:摘要精神分裂症(sz)患者一直存在嗅觉识别缺陷,但人们对这种缺陷的性质和特征及其与疾病现象学的关系知之甚少.本研究旨在通过研究患者的人口统计学差异与气味识别能力之间的关系,进一步界定精神分裂症患者的气味识别错误.我们的研究结果表明,患者的性别和教育程度与气味识别得分有关,女性患者和教育程度较高的患者的气味识别得分更高.然而,年龄,种族或社会经济地位对气味识别没有影响.气味识别缺陷也与患者的临床特征无关,包括首次住院的年龄,精神病住院次数和病程.气味识别能力也不因精神分裂症亚型而异,也不因精神分裂症患者和精神分裂情感障碍患者而异.这些研究结果强调,Sz患者的气味识别障碍与临床疾病特征无关,不能用普通人群中与嗅觉有关的其他混杂因素来解释,而且可能是与sz疾病过程有关的核心特征.
DOI:10.1017/s1092852900022252

专利信息

专利号:US-4178447-A
优先权日:1977-09-23
标 题:Novel synthesis of 3,3-substituted dihydrobenzisothiazole-1,1-dioxides and -2,3-dihydronaphtho-1,2-thiazine-1,1-dioxides
发明人：BORROR ALAN L; FOLEY JAMES W; KAMPE MARCIS M; LEE JOHN W JR
权利人:POLAROID CORP
摘要:This invention relates to a method of synthesizing certain 3-(carbocyclic aryl)-3-(4'-OP-carbocyclic aryl)-2,3-dihydrobenz[d]isothiazole-1,1-dioxides (and -2,3-dihydronaphtho[1,8-de]-1,2-thiazine-1,1-dioxides) by reacting (a) a 4-OP-carbocyclic aryllithium compound wherein P is a protecting group and (b) a 3-(carbocyclic aryl)benz[d]isothiazole-1,1-dioxide wherein said 3-(carbocyclic aryl) moiety is other than a 3-(4'-OP-carbocyclic aryl) moiety to give (c) the corresponding 3-carbocyclic aryl)-3-(4'-OP-carbocyclic aryl)-2,3-dihydrobenz[d]isothiazole-1,1-dioxide. The -2,3-dihydronaphtho[1,8-de]-1,2-thiazine-1,1-dioxides are prepared in the same manner by reacting a 3-(carbocyclic aryl)naphtho[1,8-de]-1,2-thiazine-1,1-dioxide with said 4'-OP-carbocyclic aryllithium compound. n In a further embodiment, the compounds synthesized according to the foregoing method are reacted with a carboxylic acid halide to give the corresponding 2-carbonyl-substituted 2,3-dihydrobenz[d]isothiazole-1,1-dioxide (or -2,3-dihydronaphtho[1,8-de]-1,2-thiazine-1,1-dioxides) followed by removing the protecting group, P, with weak acid to yield certain phenol and 1-naphthol sulfam(na)phthaleins useful, e.g., as optical filter agents and filter agent precursors in photography.

专利号:US-4181660-A
优先权日:1977-09-23
标题:3-Substituted benz[d]isothiazole-1,1-dioxides
发明人：BORROR ALAN L; CINCOTTA LOUIS; ELLIS ERNEST W; FOLEY JAMES W; KAMPE MARCIS M
权利人:POLAROID CORP
摘要:This invention relates to 3-(phenyl/naphthyl)-benz[d]isothiazole-1,1-dioxides wherein the 3-phenyl or the 3-naphthyl group is substituted in the para position with hydroxy blocked with certain protecting groups. These compounds are useful as intermediates in the synthesis of certain 3,3-disubstituted-2,3-dihydrobenz[d]isothiazole-1,1-dioxide dyes which find utility, for example, as photographic optical filter agents and filter agent precursors.