CAS: 33996-58-6; 2-(2-Oxopyrrolidin-1-yl)Butanamide

上下游产品

α-ethyl-2-oxo-1-pyrrolidineacetic acid, levetiracetam8H8O3*C8H14N2O2C8H8O3*C8H14N2O2

左乙拉西坦置于sodium Methylate体系中,用 甲醇 作为反应溶剂,化学反应 24.0H,反应生成 益智酰胺
参考文献:Ternary And Quaternary Phase Diagrams: Key Tools For Chiral Resolution Through Solution Cocrystallization
标题:Ternary And Quaternary Phase Diagrams: Key Tools For Chiral Resolution Through Solution Cocrystallization
摘要:本文旨在引导读者构建和理解四元相图,从而通过溶液中的共结晶法获得手性分离的最佳条件.本文将结合实验结果对整体描述进行说明,实验系统涉及rs-2-(2-氧代吡咯烷-1-基)丁酰胺作为待分离的手性原料药,S-扁桃酸作为手性共晶剂.
DOI:10.1039/c3Ce41141A

专利信息

专利号:US-2023183177-A1
优先权日:2020-04-24
标题:Enantioselective chemo-enzymatic synthesis of optically active amino amide compounds
发明人：GRILL BIRGIT; WINKLER MARGIT; SCHWAB HELMUT; STROHMEIER GERNOT; DONSBACH KAI; WALDVOGEL SIEGFRIED R; ARNDT SEBASTIAN; WEIS DOMINIK
权利人:PHARMAZELL GMBH
摘要:The present invention relates to a novel biocatalytic process for the stereoselective preparation of alpha amino amide compounds catalyzed by NHase enzymes. A further aspect of the invention relates to novel NHase enzymes as well as further improved NHase enzyme mutants, nucleic acid molecules encoding these enzymes, recombinant microorganisms suitable for preparing such enzymes and mutants. Another aspect of the invention relates to a chemo-biocatalytic process for the preparation of lactam compounds comprising the new catalytic process for the preparation of alpha amino amide compounds catalyzed by NHase enzymes, as well as the chemical oxidation of the alpha amino amide by applying certain chemical oxidation catalysts suitable for converting the alpha amino amide under retention of its stereochemical configuration to the respective lactam. The novel chemo-biocatalytic process is particularly suited for the synthesis of valuable pharmaceutical compounds, like in particular (S)-Levetiracetam.

专利号:US-8338621-B2
优先权日:2005-12-21
标题:Process for the preparation of 2-oxo-1-pyrrolidine derivatives
发明人：SURTEES JOHN; BOUVY DIDIER; THOMAS ANTOINE; COMBRET YVES; FRANK MICHAEL; SCHMIDT GUNTHER; DUCHENE GUY
权利人:SURTEES JOHN; BOUVY DIDIER; THOMAS ANTOINE; COMBRET YVES; FRANK MICHAEL; SCHMIDT GUNTHER; DUCHENE GUY; UCB SA
摘要:The present invention relates to alternative processes for the preparation of 2-oxo-1-pyrrolidine derivatives of formula (I) n n n n n n n n n n Particularly, the present invention relates to alternative processes for the synthesis of levetiracetam, brivaracetam and seletracetam.

专利号:EP-2524910-A1
优先权日:2011-05-17
标题 :Process for the resolution of aminobutyramide
发明人：BOESTEN WILHELMUS HUBERTUS JOSEPH; BOONEN JOZEF JOHANNES CATHERINA JACOBUS; WOESTENBORGHS PIERRE LOUIS
权利人:DSM IP ASSETS BV
摘要:The present invention relates to a process for the resolution of Schiff bases of racemic ( R,S )-2-aminobutyramide to give optically pure ( S )-2-aminobutyramide, an intermediate in the synthesis of levetiracetam.

专利号:US-2009176740-A1
优先权日:2007-11-30
标题:Treatment of neurological conditions by the co-administration of aniracetam and l-alpha glycerylphosphorylcholine
发明人：PHILLIPS II DAUGLAS JAMES
权利人:PHILLIPS II DAUGLAS JAMES
摘要:Aniracetam (1-[(4-methoxybenzoyl)]-2-pyrrolidinone) is co-administered with the acetylcholine precursor 1-alpha glycerylphosphorylcholine (Alpha GPC, choline alfoscerate, choline alphoscerate) to potentiate cognition enhancing effects in healthy subjects and patients suffering from neurological conditions including Alzheimer's Disease (AD), attention deficit disorder (ADD), Parkinson's Disease, schizophrenia, vascular dementia, post stroke aphasia, anxiety disorders, cerebral atrophy, chronic alcoholism, Down syndrome, dyslexia, and various other neurodegenerative conditions. The co-administration of aniracetam (and other racetam derivatives including oxiracetam) with the acetylcholine precursor 1-alpha glycerylphosphorylcholine decreases negative side-effects such as severe headaches while increasing the synthesis and release of the neurotransmitters acetylcholine and glutamate to facilitate proper brain functioning.

专利号:CN-109678752-A
优先权日:2018-12-27
标 题:A kind of method for asymmetric transformation and synthesis of L-2-aminobutanamide hydrochloride

专利号:WO-2021214283-A1
优先权日:2020-04-24
标题 :Enantioselective chemo-enzymatic synthesis of optically active amino amide compounds