CAS: 369-34-6; 3,4-Difluoronitrobenzene

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CAS号367-11-3 邻二氟苯 | CAS号20372-63-8 4,5-二氟-2-硝基苯甲酸 | CAS号97-00-7 1-氯-2,4-二硝基苯 | CAS号350-30-1 3-氯-4-氟硝基苯 | CAS号115561-03-0 1-fluoro-2-fluo... | CAS号99-54-7 1,2-二氯-4-硝基苯 | CAS号70-34-8 2,4-二硝基氟苯 | CAS号611-06-3 2,4-二氯硝基苯 | CAS号350-46-9 对氟硝基苯 | CAS号946-30-5 2-氯-5-硝基苯磺酸钠 | CAS号455-93-6 2-氟-4-硝基苯甲醚 | CAS号385380-74-5 1-(2-氟-4-硝基苯基)四氢吡咯 | CAS号403-19-0 2-氟-4-硝基苯酚 | CAS号337529-74-5 2-氟-4-硝基苯乙酸甲酯 | CAS号369-35-7 2-氟-4-硝基苯胺 | CAS号315228-19-4 2-氟-4-硝基苯乙酸 | CAS号188975-47-5 DIMETHYL 2-(2-F... | CAS号252561-33-4 2-氟-1-(甲基磺酰基)-4-硝基苯 | CAS号250371-88-1 4-(2-氟-4-硝基苯氧基)... | CAS号252337-29-4 1-(2-fluoro-4-n...

1,2-二氟苯置于硫酸,硝酸体系中,化学反应 6.0H,以55.4 G的收率获得3,4-二氟硝基苯
参考文献:以四氟乙烯和 1,3-二烯为起始构件合成氟化卤代硝基苯和卤代硝基苯酚
标题:以四氟乙烯和 1,3-二烯为起始构件合成氟化卤代硝基苯和卤代硝基苯酚
摘要:在 495-505 oc 的流动反应器中,四氟乙烯与丁-1,3-二烯的气相复制反应生成3,3,4,4-四氟环己-1-烯,其选择性地转化为 1,2-二氟苯或1-氯-2,3-二氟苯.后者可通过硝化,氟脱氯作用转化为2-氯-3,4-二氟硝基苯,2,3,4-三氟硝基苯,2,3-二氟-6-硝基苯酚或2-氯-3-氟-4-硝基苯酚,和水解反应.
Doi:10.1007/s11172-021-3327-8

专利信息

专利号:WO-2005051933-A1
优先权日:2003-11-28
标题 :An improved process for the synthesis of 4-(4-benzyloxy-carbonylamino-2-fluorophenyl)-piperazine-1-carboxylic acid tert-butyl ester, a key intermediate for oxazolidinone antimicrobials and compounds prepared thereby
发明人：KUMAR YATENDRA; KAUL VIJAY KUMAR; SINGH NITU; YADAV GYAN CHAND
权利人:RANBAXY LAB LTD; KUMAR YATENDRA; KAUL VIJAY KUMAR; SINGH NITU; YADAV GYAN CHAND
摘要:Provided herein are process for the synthesis of the 4-(4-benzyloxy-carbonylamino-2-fluorophenyl)-piperazine-1-carboxylic acid tert-butyl ester, which is a key intermediate in the synthesis of oxazolidinone compounds having antibacterial activity. Also provided herein are processes for preparing oxazolidinone compounds. In addition, compounds prepared by the processes provided herein are also encompassed. Formula (I) and Formula (II).

专利号:US-5354439-A
优先权日:1990-07-16
标 题 :Process for the synthesis of fluorinated derivatives
发明人：FORAT GERARD; GILBERT LAURENT; LANGLOIS BERNARD
权利人:RHONE POULENC CHIMIE
摘要:A process for the synthesis of fluorinated organic compounds and a reagent suitable for use in the process. The process is carried out by exchange with fluorides, while preferably agitating the reaction medium with ultrasonic sound.

专利号:US-2022315594-A1
优先权日:2019-08-09
标 题 :Method of synthesis of compound for dual inhibition of jak2 and bet
发明人：UPADHAYAYA RAM SHANKAR; UKKALAM MURALI KRISHNA; SARMA K NARASIMHA
权利人:OHM ONCOLOGY
摘要:Embodiments of the invention include quinoline compounds and methods of synthesis. Ohm-581 has demonstrated dual inhibition of JAK2 and BET and acts as a therapeutic agent for micosis fungoides (MF) and other hematologic malignancies. Embodiments also include an efficient process for the preparation of Ohm-581 and pharmaceutically acceptable salts. The process is suited for large-scale production of quinoline compounds including Ohm-581.

专利号:US-9233989-B2
优先权日:2011-10-11
标题:Sila analogs of oxazolidinone derivatives and synthesis thereof
发明人：REDDY DUMBALA SRINIVASA; BALAMKUNDU SEETHARAM SINGH; RAMESH REMYA
权利人:COUNCIL SCIENT IND RES
摘要:The invention discloses silaanalogs of oxazolidinone compounds, to pharmaceutical compositions and to the synthesis of the oxazolidinone derivatives of formula I. The invention further relates to methods of treating a subject suffering with gram positive pathogens including those resistant to methicillin and vancomycin using the compound(s) or modulation of coagulation properties of blood-clotting cascade or compositions of the oxazolidinone derivatives of the invention.

专利号:US-6448449-B2
优先权日:2000-04-21
标题:Process for preparation of (R)-1- (aryloxy)propan-2-ol
发明人：LARROW JAY FRANCIS
权利人:RHODIA CHIREX INC
摘要:A process for the preparation of (R)-1-(2,3-difluoro-6-nitrophenoxy)-propan-2-ol, which is a useful intermediate in the synthesis of the widely used antibiotic Levofloxacin is provided. A process for the preparation of (R)-1-(2,3-difluoro-6-nitrophenoxy)-2-trimethylsiloxypropane is also described. The process includes the ring opening of (R)-propylene oxide with 2,3-difluoro-6-nitrophenyl trimethylsilyl ether in the presence of an optically active Co(salen) catalyst. The trimethylsilyl group of the reactant is transferred to the product aryloxy alcohol, which serves to protect the secondary alcohol in situ. Upon isolation, the trimethylsilyl group is removed and the resulting regioisomeric mixture purified to yield the desired (R)-1-(2,3-difluoro-6-nitrophenoxy)-propan-2-ol in high purity and yield.

专利号:US-2010286211-A1
优先权日:2004-10-08
标题:Oxazolidinone derivatives as antimicrobials
发明人：DAS BISWAJIT; AHMED SHAHADAL; YADAV AJAY SINGH; GHOSH SOMA; GUJRATI ARTI; SHARMA PANKAJ; RATTAN ASHOK
权利人:DAS BISWAJIT; AHMED SHAHADAL; YADAV AJAY SINGH; GHOSH SOMA; GUJRATI ARTI; SHARMA PANKAJ; RATTAN ASHOK
摘要:The present invention relates to certain substituted phenyl oxazolidinones and to processes for the synthesis of the same. This invention also relates to pharmaceutical compositions containing the compounds of the present invention as antimicrobials. The compounds are useful antimicrobial agents, effective against a number of human and veterinary pathogens, including gram-positive aerobic bacteria, for example, multiple-resistant staphylococci, streptococci and enterococci as well as anaerobic organisms, for example, Bacterioides spp. and Clostridia spp. species, and acid fast organisms, for example, Mycobacterium tuberculosis, Mycobacterium avium and Mycobacterium spp.