CAS: 37860-51-8; ((Oxybis(Ethane-2,1-Diyl))Bis(Oxy))Bis(Ethane-2,1-Diyl) Bis(4-Methylbenzenesulfonate)

该化合物是一种双功能聚乙烯(PEG)衍生物,以两端的全美类为主,具有超模性,在生物合成和交叉联系应用中起着多功能联系器的作用,使分子之间能够引入PEG空间器.Tylate组群对核粒子反应性很强,有利于与胺,硫柳或其他核子功能组群有效结合.PEG4空间器增强溶解性,减少消毒障碍,提高浸泡合成,蛋白质改变和聚合化学的反应效率.其对称结构确保了统一的再活动性,使之适合受控分子组装.Bis-Tes-PEG4在药物运载系统和生物材料开发中特别有用,因为精确的间隔和生物兼容性至关重要.

结构式图片

欧盟法规

ECHA物质C&L通报

上下游产品

Tetraethylene glycol p-toluenesulfonyl chloride 2,2'-[1,2-ethanediylbis(oxy)]bisethanol10,14-bis-(toluene-4-sulfonyl)-1,4,7-trioxa-10,14-diaza-cyclohexadecane 16-(p-Tolylsulfonyl)-1,4,7,10,13-pentaoxa-16-azacyclo°Ctadecan 10,13,16-tris(p-tolylsulphonyl)-1,4,7-trioxa-10,13,16-triazacyclo-°Ctadecane 10,14,18-tris(p-tolylsulphonyl)-1,4,7-trioxa-10,14,18-triazacycloicosane

合成工艺路线路线简述

    海关参考信息

    专利信息


    专利号:US-7777023-B2
    优先权日:1998-10-23
    标题 :Method for the chemical synthesis of oligonucleotides
    发明人:VARGEESE CHANDRA; SHAFFER CHRISTOPHER; WANG WEIMIN
    权利人:SIRNA THERAPEUTICS INC
    摘要:The present invention features novel compositions, linkers, derivatized solid supports, and methods for the efficient solid phase synthesis of oligonucleotides, including RNA, DNA, RNA-DNA chimeras, and analogs thereof.

    专利号:US-5447709-A
    优先权日:1992-10-26
    标题:Process for the synthesis of zeolites belonging to the faujasite structural family
    发明人:ANGLEROT DIDIER; FERON BEATRICE; GUTH JEAN-LOUIS
    权利人:ELF AQUITAINE
    摘要:Process for the synthesis of faujasite, having a Si/Al ratio greater than 1 and which can exceed 3, in the presence of a structuring agent consisting of at least one carbonaceous macrocycle having 10 to 24 atoms per ring and containing heteroatoms chosen from oxygen, nitrogen, sulphur or silicon, the macrocycle being introduced into the reaction medium in the form of a crude synthetic sodium complex.

    专利号:US-2024400533-A1
    优先权日:2023-06-02
    标题 :General Solid-Phase Synthesis of Crown Ethers
    发明人:TRANT JOHN F; NASRI SARAH; HAYWARD JOHN J
    权利人:UNIV OF WINDSOR
    摘要:In a preferred embodiment, there is provided a method for preparing a crown ether, the method comprising: loading a resin having a resin functional group with a linking compound having a functional group selected for coupling to the resin functional group and at least two carbon atoms each having a substituent; coupling the linking compound to a polyethylene glycol having two terminal carbon atoms each bonded to an optionally protected terminal hydroxyl group to obtain a cyclized intermediate, whereby one said at least two carbon atoms or the substituent and an associated one of the two terminal carbon atoms or the hydroxyl groups undergo a coupling or substitution reaction; and removing the linking compound and the cyclized intermediate from the resin.

    专利号:US-7205399-B1
    优先权日:2001-07-06
    标 题 :Methods and reagents for oligonucleotide synthesis
    发明人:VARGEESE CHANDRA; WANG WEIMIN
    权利人:SIRNA THERAPEUTICS INC
    摘要:The present invention features novel compositions, linkers, derivatized solid supports, and methods for the efficient solid phase synthesis of oligonucleotides, including RNA, DNA, RNA-DNA chimeras, and analogs thereof.

    专利号:US-7658868-B2
    优先权日:2002-03-20
    标 题 :Molecular actuators, and methods of use thereof
    发明人:ANQUETIL PATRICK A; HUNTER IAN W; MADDEN JOHN D; MADDEN PETER G; PULLEN ANTHONY E; SWAGER TIMOTHY M; XU BING; YU HSIAO-HUA
    权利人:MASSACHUSETTS INST TECHNOLOGY; US NAVY
    摘要:The synthesis of thiophene based conducting polymer molecular actuators, exhibiting electrically triggered molecular conformational transitions is reported. Actuation is believed to be the result of conformational rearrangement of the polymer backbone at the molecular level, not simply ion intercalation in the bulk polymer chain upon electrochemical activation. Molecular actuation results from Ï€-Ï€ stacking of thiophene oligomers upon oxidation, producing a reversible molecular displacement that leads to surprising material properties, such as electrically controllable porosity and large strains. The existence of active molecular conformational changes is supported by in situ electrochemical data. Single molecule techniques have been used to characterize the molecular actuators.

    专利号:US-2006036090-A1
    优先权日:1998-10-23
    标题:Method for the chemical synthesis of oligonucleotides
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    ✅ COA系统入驻 | 共享模式

    主要参考文献

    [参考文献]: An S, Et Al. Small-Molecule Protacs: An Emerging And Promising Approach For The Development Of Targeted Therapy Drugs. Ebiomedicine. 2018 Oct;36:553-562.
    [参考文献]: Daniel Collado, Et Al. Bis(Isoquinoline N-Oxide) Pincers As A New Type Of Metal Cation Dual Channel Fluorosensor. Org Lett. 2002 Mar 7;4(5):855-8.

    合成参考文献


    摘要:Haino, T.; Iwamoto, H., Science of Synthesis, (2010) 45, 1210.
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