CAS: 38002-45-8; (3-Bromoprop-1-Yn-1-yl)Trimethylsilane

该化合物是有机硅化合物,其特征是,含有一种含溴替代品的丙酰酶,含有一种溴基化合物,该化合物一般是无色的,可与黄色液体无关,并因其具有反作用而闻名,因为有亚克林功能组和溴原子,可参与各种化学反应,包括核生殖替代和混合反应.三甲基硅基化合物可增强该化合物在有机溶剂中的稳定性和溶性,使其在合成有机化学中有用,特别是在形成碳-碳联结方面.此外,溴原子的存在可促进进一步的功能化,允许引入多种化学组.在处理该化合物时,应注意安全防范措施,因为它可能构成有机溴化合物的典型健康危害.

结构式图片

相似化合物

69361-41-7 6224-91-5 62108-37-6

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合成工艺路线路线简述

  • 合成目标产物 3-Bromo-1-(Trimethylsilyl)-1-Propyne 主要起始原料 3-Trimethylsilyl-2-Propyn-1-Ol
  • (文献来源)合成步骤主要原料 3-Trimethylsilyl-2-Propyn-1-Ol
3-(Tetrahydropyran-2-Yloxy)-1-Trimethylsilylprop-1-Yne置于溴,三苯基膦体系中,用 甲醇,二氯甲烷 用作溶剂,化学反应 9.0H,反应生成3-溴-1-三甲基硅基-1-丙炔
参考文献:胸腺胸腺性信息素的鉴定研究
标题:胸腺胸腺性信息素的鉴定研究
摘要:紫罗兰(algarta Parda)thyrinteina Arnobia(鳞翅目:Geometridae),巴西重要植物,巴西番石榴(psidium Guajava),异国情调,桉树等.阿根廷雀巢的雀巢trabalho E Relatado O Isolamento Dos的组成部分,微粉尘外表层(spme)的女性特征.作为通气孔菌的通气孔,作为气体质谱仪(cg-Ead)和电子质谱仪(cg-Em).Cg-Em Sugeriram和3,4-Epoxi-6,9-Eneicosadieno Como组成部分的分析物,作为电镜观察台.排在第10位的印尼总得主,占全球总收入的28%.孔雀斑菌或季戊四醇酯类环氧化合物.桉树棕环黄胸腺(lepidoptera:Geometridae)被认为是巴西本土植物(如番石榴)和外来植物(如桉树)的重要害虫.在这项工作中,我们描述了使用原始女性的腺体提取物和固相微
Doi:10.5935/0103-5053.20130241

海关参考信息

专利信息


专利号:US-6252079-B1
优先权日:1993-06-30
标 题 :Intermediates in the synthesis of camptothecin and related compounds and synthesis thereof
发明人:CURRAN DENNIS P; BOM DAVID
权利人:UNIV PITTSBURGH
摘要:The present invention provides a short, convergent total synthesis of irinotecan and derivative compounds which comprises of a novel 4+1 radical annulation wherein the precursoris reacted with an aryl isonitrile having the formulawherein X is Br or I, and R4 is an alkyl group, an allyl group, a propargyl group or a benzyl group, and R16 is H, a C1-C6 alkoxy group, agroup wherein p is an integer between 4 and 12, or a C1-C12 acyclic dialkylamino group. The present invention also provides novel chemical intermediates for such 4+1 radical annulations.

专利号:US-2025026768-A1
优先权日:2023-06-30
标题:Method for the synthesis of axially chiral organoboron compounds
发明人:PING YIFAN; CHE CHI-MING
权利人:LABORATORY FOR SYNTHETIC CHEMISTRY AND CHEMICAL BIOLOGY LTD
摘要:A highly efficient and atroposelective Rh-catalyzed [2+2+2] cycloaddition for the synthesis of axially chiral aryboron compounds is developed. The reactions of diynes and alkynylborons smoothly occur in an atom-economical manner, affording a variety of C—B atropisomers in excellent yields and enantioselectivities. The protocol features mild conditions, broad substrate scope, and good functional tolerance. The obtained C—B atropisomers show powerful synthetic applications in terms of producing novel chiral phosphine ligands.

专利号:US-6982333-B2
优先权日:1993-06-30
标 题:Intermediates in the synthesis of camptothecin and related compounds and synthesis thereof
发明人:CURRAN DENNIS P; JOSIEN HUBERT; KO SUNG BO
权利人:UNIV PITTSBURGH
摘要:The present invention provides a short, convergent total synthesis of camptothecin and related compounds which consists of a novel 4+1 radical annulation. The present invention also provides novel chemical intermediates for such 4+1 radical annulations.

专利号:US-6603070-B2
优先权日:2000-07-21
标题 :Convergent synthesis of multiporphyrin light-harvesting rods
发明人:LINDSEY JONATHAN S; LOEWE ROBERT S
权利人:UNIV NORTH CAROLINA STATE
摘要:The present invention provides a convergent method for the synthesis of light harvesting rods. The rods are oligomers of the formula A 1 (A b+1 ) b , wherein b is at least 1, A 1 through A b+1 are covalently coupled rod segments, and each rod segment A 1 through A 1+b comprises a compound of the formula X 1 (X m+1 ) m wherein m is at least 1 and X 1 through X m+1 are covalently coupled porphyrinic macrocycles. Light harvesting arrays and solar cells containing such light harvesting rods are also described, along with intermediates useful in such methods and rods produced by such methods.

专利号:US-9556140-B2
优先权日:2013-01-26
标 题 :Approach for synthesis of catechins
发明人:DUGAR SUNDEEP; MAHAJAN DINESH; RAI KUMAR SANTOSH; TRIPATHI VINAYAK; PATIL ISHWAR RAKESH
权利人:SPHAERA PHARMA PRIVATE LTD
摘要:A process for synthesis of enatiomerically pure or enatiomerically enriched or racemic mixture of (+ and/or −) epicatechin and its intermediates, comprising the steps of: (i) obtaining penta-protected quercetin; (ii) reducing the penta-protected quercetin obtained from step (i); (iii) optionally deprotecting the compound of step (ii); (iv) reducing the compound obtained from step (ii) or step (iii) in the presence of a chiral/achiral reducing agent to obtain a chiral intermediate; (v) deprotecting and/or hydrogenation of the chiral intermediate obtained from step (iv) to obtain (−)-epicatechin; (vi) optionally simultaneously deprotecting and by drogenation of the compound obtained from step (ii) to obtain racemic epicatechin.

专利号:US-6455680-B1
优先权日:2000-12-21
标 题 :Methods utilizing aryl thioimines in synthesis of erythromycin derivatives
发明人:LUKIN KIRILL A
权利人:ABBOTT LAB
摘要:An efficient deoximation technique for use in synthesis of erythromycin derivatives, involving aryl thioimine intermediates is disclosed. The aryl thioimine intermediates can be utilized in a method for protecting a ketone of a ketone-containing erythromycin derivative as a thioimine; a method for deoximating an oxime-containing erythromycin derivative, or a method for preparing a 6-O-alkyl erythromycin derivative. Presently preferred erythromycin derivatives have a C-9 oxime or a C-9 ketone.
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合成参考文献


摘要:Araki, S.; Hirashita, T., Science of Synthesis Knowledge Updates, (2010) 4, 145.
摘要:Krause, N.; Arisetti, N., Science of Synthesis Knowledge Updates, (2020) 3, 81.
摘要:Yanagisawa, A., Science of Synthesis Knowledge Updates, (2010) 4, 195.
摘要:Yanagisawa, A., Science of Synthesis Knowledge Updates, (2010) 4, 196.
摘要:Pitaval, A.; Echavarren, A. M., Science of Synthesis: Cross Coupling and Heck-Type Reactions, (2012) 1, 571.
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