CAS: 40635-66-3; 1-Chloro-2-Methyl-1-Oxopropan-2-Yl Acetate

相似化合物

36394-75-9 13831-31-7

上下游产品

O-acetyl-α-hydroxyisobutyric acid 2-methyllactic acid acetic anhydride acetyl chloride 1-(2,5-dimethylphenyl)-1-ethanone α-acetoxy-isobutyric acid phenyl ester 2-Acetoxy-2-methyl-propionic acid 4-nitro-phenyl ester 2-chloro-1-phenylethyl acetate

2-乙酰氧基-2-甲基丙酸置于草酰氯,N,N-二甲基甲酰胺体系中,用 二氯甲烷 作为反应溶剂,化学反应生成 2-乙酰氧基异丁酰氯
参考文献:新型丙酮酸脱氢酶激酶抑制剂的设计,合成与评价
标题:新型丙酮酸脱氢酶激酶抑制剂的设计,合成与评价
摘要:目的:目前的工作描述了作为丙酮酸脱氢酶激酶 (Pdk) 抑制剂的新型化合物的合成和生物学评价.这些药物应该成为一种新的治疗方法,用于治疗通过控制血乳酸水平而改善的病症.方法:制备属于 N-(4-(N-烷基/芳烷基氨磺酰基)苯基)-2-甲基丙酰胺和 1,2,4-苯并噻二嗪 1,1-二氧化物的四个系列化合物,并作为 Pdk 抑制剂进行评估.结果:新合成的 N-(4-(N-烷基/芳烷基氨磺酰基)苯基)-2-甲基丙酰胺在结构上与先前报道的参考化合物 4 和 5 相关,被发现是有效的 Pdk 抑制剂(即 10D:Ic50 = 41 Nm).1,2,4-苯并噻二嗪 1,在 6 位带有 (甲基/三氟甲基)-丙酰胺部分的 1-二氧化物也被设计为 N-(4-(N-烷基/芳烷基氨磺酰基)苯基)-2-羟基-2-的构象限制闭环类似物甲基丙酰胺.他们中的大多数被发现不如他们的开环类似物有效.有趣的是,4-位烃侧
DOI:10.2174/1573406418666220819102627

专利信息

专利号:WO-2025104624-A1
优先权日:2023-11-14
标题 :Synthesis of 1,5-anhydro-3-({5-chloro-4-[4-fluoro-2-(2-hydroxypropan-2-yl)-1-(propan-2-yl)-1h-benzimidazol-6-yl]pyrimidin-2-yl}amino)-2,3-dideoxy-d-threo-pentitol
发明人：ALEXANDER KATY LOUISE; ANSARI ZARRIN FAZAL KHADIJA; DANIELS DAVID SYDNEY BERNARD; HASSEL LUKE HARRY; KEEN STEPHEN PHILIP; SCOTT JEREMY PETER; SCOTT REUBEN JOHN; SIMMONS JOHATHAN ANDREW; STOLL EMMA LOUISE; TRINDADE ALEXANDRE FONSECA; VICINI ANNA CHIARA
权利人:PFIZER
摘要:This disclosure relates novel methods to prepare 1,5-anhydro-3-({5-chloro-4-[4- fluoro-2-(2-hydroxypropan-2-yl)-1-(propan-2-yl)-1H-benzimidazol-6-yl]pyrimidin-2- yl}amino)-2,3-dideoxy-D-threo-pentitol, and hydrates and stereoisomers thereof, as well as intermediates, including solid forms of the intermediates, useful for the preparation of such compounds and the synthesis of said intermediates.

专利号:US-5200514-A
优先权日:1990-01-19
标 题 :Synthesis of 2'-deoxypyrimidine nucleosides
发明人：CHU CHUNG K
权利人:UNIV GEORGIA RES FOUND
摘要:A method for the preparation of 2'-deoxynucleosides and 2',3'-dideoxy-2',3'-didehydronucleosides that includes the step of reacting a nucleoside having hydroxyl groups in the 2' and 3' positions with a mixture of acyl bromide or chloride and HX, wherein X is Br or Cl, at moderate temperature, to give a haloacyl nucleoside derivative that can be deprotected and reduced to form the desired compound.

专利号:US-6927291-B2
优先权日:2001-03-01
标 题:Method for the synthesis of 2′,3′-dideoxy-2′,3′-didehydronucleosides
发明人：JIN FUQIANG; CONFALONE PASQUALE N
权利人:PHARMASSET LTD
摘要:An efficient synthetic route to antiviral 2′,3′-dideoxy-2′,3′-didehydro-nucleosides, such as 2′,3′-dideoxy and 2′- or 3′-deoxyribo-nucleoside analogs, from available precursors is disclosed, with the option of introducing functionality as needed. In one embodiment, a method for the preparation of β-D and β-L-2′,3′-dideoxy-2′,3′-didehydro-nucleosides is described that includes: activating a compound of structure (1) n n nwherein B is a pyrimidine or purine base and Y is O, S or CH 2 with an acyl halide of the formula X—C(â•?O)R 1 , X—C(â•?O)C(R 1 ) 2 OC(â•?O)R 1 or X—C(â•?O)OR 1 (wherein X is a halogen, and each R 1 is independently hydrogen, lower alkyl, alkyl, aryl or phenyl); reducing the resulting compound with a reducing agent to form a 2′,3′-dideoxy-2′,3′-didehydro-nucleoside; and optionally deprotecting the nucleoside. The haloacylation of the first step can form the 2′-acyl-3′-halonucleoside, the 3′-acyl-2′-halonucleoside, or a mixture thereof.

专利号:US-2009118296-A1
优先权日:2005-07-20
标 题:Heteroaromatic Compounds As Inhibitors Of Stearoyl-Coenzyme A Delta-9 Desaturase
发明人：BLACK CAMERON; DESCHENES DENIS; GAGNON MARC; LACHANCE NICOLAS; LEBLANC YVES; LEGER SERGE; LI CHUN SING; OBALLA RENATA M
权利人:MERCK FROSST CANADA LTD
摘要:Heteroaromatic compounds of structural formula (I) are selective inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD1) relative to other known stearoyl-coenzyme A desaturases. The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease; atherosclerosis; lipid disorders; obesity; diabetes; neurological disease; metabolic syndrome; insulin resistance; and fatty liver disease.

专利号:CA-2439836-A1
优先权日:2001-03-01
标 题 :Method for the synthesis of 2',3'-dideoxy-2',3'-didehydronucleosides

专利号:US-2005250946-A1
优先权日:2001-03-01
标 题 :Method for the synthesis of 2',3'-dideoxy-2',3'-didehydronucleosides