CAS: 53558-93-3; (R)-5-Oxotetrahydrofuran-2-Carboxylicacid

相似化合物

21461-84-7 4344-84-7 32780-06-6

上下游产品

CAS号6893-26-1 D-谷氨酸 | CAS号56-86-0 L-谷氨酸 | CAS号52813-63-5 (R)-5-羟甲基二氢呋喃-2-酮 | CAS号78158-90-4 (R)-(-)-γ-三苯甲基甲... | CAS号19041-15-7 (S)-γ-Valerolactone | CAS号58879-33-7 R-(-)-二氢-5-(P-甲... | CAS号128075-94-5 5-(1-diphenylsi... | CAS号147058-39-7 2',3'-dideoxy-b... | CAS号70606-00-7 (2R)-Tetrahydro... | CAS号54848-33-8 (S)-5-氧代四氢呋喃-2-羧酸

D-谷氨酸置于盐酸,Sodium Nitrite体系中,用 水 作为反应溶剂,化学反应生成 (R)-(-)-5-氧代-2-四氢呋喃羧酸
参考文献:富含对映体的n-(2-氯烷基)-3-乙酰氧基哌啶类化合物可能作为胆碱毒性药物.螺环叠氮鎓形成的合成和初步证据
标题:富含对映体的n-(2-氯烷基)-3-乙酰氧基哌啶类化合物可能作为胆碱毒性药物.螺环叠氮鎓形成的合成和初步证据
摘要:报道了代表乙酰胆碱的环状形式的六个对映体富集的类似物的合成.(S)-和(R)-N-(2-氯乙基)-3-乙酰氧基哌啶和(r,R)-,(r,S)-,(s,R)-和(s,S)-N从(R)-或(S)-3-羟基哌啶经五步合成了-(2-氯丙基)-3-乙酰氧基哌啶.(R)-和(S)-3-羟基哌啶可通过平行的立体定向途径从d-和1-谷氨酸进入,并通过非对映异构的tartranilic酸盐的分级重结晶而获得.((S)-N-(2-氯乙基)-3-乙酰氧基哌啶与高氯酸银反应形成乙酰胆碱的螺环叠氮基类似物,这是由叠氮基亚甲基的特征性1 H NMR位移所证明的.
DOI:10.1016/0040-4020(95)00285-G

专利信息

专利号:US-6632942-B2
优先权日:2000-05-04
标题:Asymmetric synthesis of piperazic acid and derivatives thereof
发明人：ROBIDOUX ANDREA L C; SERAFINI SIRO; DIETERICH PETRA; LEONARDI STEFANIA; STIBBARD JOHN
权利人:VERTEX PHARMA
摘要:This invention provides a concise, asymmetric synthesis of piperazic acid and derivatives thereof, whereby either the (3S)- or (3R)-enantiomeric form may be obtained with high optical purity. (3S)-piperazic acid is derived from D-glutamic acid through an (R)-2,5-dihydroxyvalerate ester intermediate. After the hydroxy groups are converted to suitable leaving groups, such as mesylates, the ester is treated with a bis-protected hydrazine to provide the desired (3S)-piperazic acid derivative. The (3R) enantiomer of piperazic acid may be similarly obtained starting with L-glutamic acid. The method may also be used to obtain piperazic acid derivatives that have moderate optical purity or are racemic. By this method, piperazic acid derivatives may be obtained that are useful as intermediates for pharmacologically active compounds. For example, certain intermediates of this invention are useful for preparing caspase inhibitors, particularly inhibitors of ICE, through additional steps known in the art.

专利号:US-10035796-B2
优先权日:2014-08-14
标题:Crystalline forms of a BACE inhibitor, compositions, and their use
发明人：KAZAKEVICH IRINA; TRZASKA SCOTT; FENG TAO
权利人:MERCK SHARP & DOHME
摘要:The present invention provides a novel synthesis of verubecestat, and two novel crystalline forms of verubecestat, as well as pharmaceutically acceptable compositions thereof, each of which may be useful in treating, preventing, ameliorating, and/or delaying the onset of an Aβ pathology and/or a symptom or symptoms thereof. Non-limiting examples of such Aβ pathologies, including Alzheimer's disease, are disclosed herein.

专利号:US-10030003-B2
优先权日:2014-09-10
标 题:Synthesis of isoflavanes and intermediates thereof
发明人：BELIAEV NIKOLAI; SHAFRAN YURI
权利人:SYSTEM BIOLOGIE AG
摘要:Subject of the invention is a method for enantioselective production of an isoflavane from an isoflavone, comprising the steps: (a) selectively reducing the isoflavone, such that the 4-keto group of the isoflavone is converted to a 4-hydroxy group, and the 2,3-double bond of the isoflavone is converted to a 2,3-single bond, thereby obtaining a 4-hydroxy intermediate, and (b) reacting the 4-hydroxy intermediate with a chiral reagent, such that a chiral group is covalently attached to the C4-position of the 4-hydroxy intermediate, thereby obtaining a chiral intermediate. The invention also relates to intermediates of formulae (IV), (V), (VI) and (VII) obtainable in the inventive process.

专利号:US-5756706-A
优先权日:1991-05-21
标题 :Processes for the diastereoselective synthesis of nucleoside analogues
发明人：MANSOUR TAREK; TSE ALLAN H L
权利人:IAF BIOCHEM INT
摘要:The present invention relates to highly diastereoselective processes for production of cis-nucleosides and nucleoside analogues and derivatives in high optical purity, and intermediates useful in those processes.

专利号:US-11999741-B2
优先权日:2017-05-26
标 题:Process for the synthesis of 6-((3S,4S)-4-methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl)-3-(tetrahydropyran-4-yl-7H-imidazo[1,5-a]pyrazin-8-one
发明人：SVENSTRUP NIELS; ZHANG JUN; SUN JIKUI; CHEN YUYIN; KONG JIANSHE; MA RUJIAN; ZHANG JUNHUA; QIN LIANG; XIAO HUANMING; SUN JINXU; MENG XIAO; SUN FENGLAI; ZHU JINGYANG
权利人:CARDURION PHARMACEUTICALS INC
摘要:The present disclosure relates to processes for preparing 64(3s,4s)-4-methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl)-3-(tetrahydropyran-4-yl-7h-imidazo[1,5-a]pyrazin-8-one.

专利号:US-2003176691-A1
优先权日:2000-05-04
标 题:Asymmetric synthesis of piperazic acid and derivatives thereof