CAS: 537705-08-1; 2-Methoxy-N-[3-[4-[[3-Methyl-4-[(6-Methylpyridin-3-yl)Oxy]Phenyl]Amino]Quinazolin-6-Yl]Allyl]Acetamide

上下游产品

Methoxyacetyl chloride 6-iodo-N-(3-methyl-4-((6-methylpyridin-3-yl)oxy)phenyl)quinazolin-4-amine N-propargyl-2-methoxyacetamide 5-Hydroxy-2-methylpyridine

6-碘-N-(3-甲基-4-((6-甲基吡啶-3-基)氧基)苯基)喹唑啉-4-胺,Palladium Diacetate置于potassium Carbonate,三苯基膦体系中,用 水,乙酸乙酯 作为反应溶剂,化学反应生成 2-甲氧基-N-[3-[4-[[3-甲基-4-[(6-甲基-3-吡啶基)氧基]苯基]氨基]-6-喹唑啉基]-2-丙烯-1-基]乙酰胺
参考文献:Processes For The Preparation Of Substituted Bicyclic Derivatives For The Treatment Of Abnormal Cell Growth
标题:Processes For The Preparation Of Substituted Bicyclic Derivatives For The Treatment Of Abnormal Cell Growth
摘要:本发明涉及制备式11化合物的过程,以及其药学上可接受的盐,前药和溶剂化物,其中r1,R3,R4,R5,R11,M和p的定义如本文所述.式1化合物在哺乳动物中通过给予药物组成物来治疗异常细胞生长.

专利信息

专利号:US-2005192298-A1
优先权日:2004-02-27
标 题 :Crystal forms of E-2-Methoxy-N-(3-{4-[3-methyl-4-(6-methyl-pyridin-3-yloxy)-phenylamino]-quinazolin-6-yl}-allyl)-acetamide
发明人：LI ZHENG J; LEONARD JASON A
权利人:PFIZER
摘要:Crystal forms of E-2-Methoxy-N-(3-{4-[3-methyl-4-(6-methyl-pyridin-3-yloxy)-phenylamino]-quinazolin-6-yl}-allyl)-acetamide. A crystal form is useful in the synthesis of salts and complexes of E-2-Methoxy-N-(3-{4-[3-methyl-4-(6-methyl-pyridin-3-yloxy)-phenylamino]-quinazolin-6-yl}-allyl)-acetamide. A crystal form also improves stability of tabletted or capsuled E-2-Methoxy-N-(3-{4-[3-methyl-4-(6-methyl-pyridin-3-yloxy)-phenylamino]-quinazolin-6-yl}-allyl)-acetamide as a drug product.