CAS: 132992-28-0; 2-(2,3,5-Trifluorophenyl)Acetic Acid

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参考标题:New Synthesis Of 1,3-Dihydro-1,4-Benzodiazepin-2(2H)-Ones And 3-Amino-1,3-Dihydro-1,4-Benzodiazepin-2(2H)-Ones: Pd-Catalyzed Cross-Coupling Of Imidoyl Chlorides With Organoboronic Acids
作者:Alan Nadin,José M. Sánchez López,Andrew P. Owens,Dean M. Howells,Adam C. Talbot,Timothy Harrison |发布日期:2003.4.1
摘要:A New Approach To The Synthesis Of 1,4-Benzodiazepines And 3-Amino-1,4-Benzodiazepines, Which Employs The Pd-Catalyzed Cross-Coupling Reaction Of An Imidoyl Chloride With An Organometallic Reagent As The Key Step, Is Described. A Five-Step Synthesis Of A Key Intermediate Is Described And It Is Shown That In Only Four Further Steps (Three Couplings And A Tfa-Mediated Boc-Deprotection) A Wide Variety