CAS: 24228-40-8; Ethyl N-Benzylpiperidine-4-Carboxylate

上下游产品

1-苄基哌啶-4-甲酸 N-Benzylpiperidine-4-Carboxylic Acid 10315-07-8
1-苯甲酰基-4-哌啶羧酸乙酯 Ethyl 1-Benzoylpiperidine-4-Carboxylate 136081-74-8
哌啶-4-甲酸乙酯 4-Carbethoxypiperidine 1126-09-6

1-苯甲酰基-4-哌啶羧酸乙酯置于氯化镍二甲氧基乙烷,[ir(Df(Cf3)Ppy)2(Dtbbpy)](Pf6),苯硅烷体系中,用 四氢呋喃 用作溶剂,以62%的收率获得1-苄基-4-哌啶甲酸乙酯
参考文献:在酯存在下,可见光促进双光氧化还原/镍催化化学选择性还原仲和叔酰胺与氢硅烷
标题:在酯存在下,可见光促进双光氧化还原/镍催化化学选择性还原仲和叔酰胺与氢硅烷
摘要:我们报告了一种在酯存在下选择性地将仲酰胺和叔酰胺还原为其相应的胺衍生物的一步程序.这是通过光氧化还原,镍催化系统和作为还原剂的苯基硅烷在室温下蓝色发光二极管光 (455 Nm) 存在下的协同组合实现的.此外,这种温和的光促进双金属光氧化还原催化系统也成功地将内酰胺选择性还原为环胺,而不影响分子中存在的酯部分.
Doi:10.1021/acs.Joc.2C02543

专利信息

专利号:US-8487108-B2
优先权日:2005-11-14
标题 :Piperidinyl carbamate intermediates for the synthesis of aspartic protease inhibitors
发明人：BALDWIN JOHN J; CLAREMON DAVID A; TICE COLIN; CACATIAN SALVACION; DILLARD LAWRENCE W; ISHCHENKO ALEXEY V; YUAN JING; XU ZHENRONG; MCGEEHAN GERARD; SIMPSON ROBERT D; SINGH SURESH B; ZHAO WEI; FLAHERTY PATRICK T
权利人:BALDWIN JOHN J; CLAREMON DAVID A; TICE COLIN; CACATIAN SALVACION; DILLARD LAWRENCE W; ISHCHENKO ALEXEY V; YUAN JING; XU ZHENRONG; MCGEEHAN GERARD; SIMPSON ROBERT D; SINGH SURESH B; ZHAO WEI; FLAHERTY PATRICK T; VITAE PHARMACEUTICALS INC
摘要:The present invention is directed to aspartic protease inhibitors. Certain aspartic protease inhibitors of the invention can be represented by the following structural formula or a pharmaceutically acceptable salt thereof. The present invention is also directed to pharmaceutical compositions comprising the disclosed aspartic protease inhibitors. The present invention is further directed to methods of antagonizing one or more aspartic proteases in a subject in need thereof, and methods for treating an aspartic protease mediated disorder in a subject using the disclosed aspartic protease inhibitors.

专利号:WO-2004058727-A1
优先权日:2002-12-20
标题 :Substituted 3,5-dihydro-4h-imidazol-4-ones for the treatment of obesity
发明人：CHEN YUANWEI; O'CONNOR STEPHEN JAMES; GUNN DAVID; NEWCOM JASON; CHEN JIANQING; YI LIN; ZHANG HAI-JUN; HUNYADI LASZLO MATYAS; NATERO REINA
权利人:BAYER PHARMACEUTICALS CORP; CHEN YUANWEI; O'CONNOR STEPHEN JAMES; GUNN DAVID; NEWCOM JASON; CHEN JIANQING; YI LIN; ZHANG HAI-JUN; HUNYADI LASZLO MATYAS; NATERO REINA
摘要:This invention relates to substituted 3,5-dihydro-4H-imidazol-4-ones compounds which are useful in the treatment of obesity and obesity-related disorders, and as weight-loss and weight-control agents. The invention also provides methods for synthesis of the compounds, pharmaceutical compositions comprising the compounds, and methods of using such compositions for inducing weight loss and treating obesity and obesity-related disorders.

专利号:WO-2012038966-A1
优先权日:2010-09-22
标 题 :Process for the preparation of donepezil intermediate
发明人：NARAYANA RAO MUTYALA; RAMADAS CHAVAKULA; SRINIVAS RAO CHENNUPATI; SANDEEP GOKARAJU
权利人:TYCHE IND LTD; NARAYANA RAO MUTYALA; RAMADAS CHAVAKULA; SRINIVAS RAO CHENNUPATI; SANDEEP GOKARAJU
摘要:This invention relates to a process for the preparation of N-benzyl-4- formylpiperidine (I), a key intermediate used in the synthesis Donepezil. The said process comprises the decomposition of sulfoxonium complex of formula (V) in the presence of base. The compound of formula (V) may be prepared by a method comprising reacting N-Benzyl-4-hydroxymethylpiperidine (II) with dimethylsulfide and N-chlorosuccinamide; or dimethylsulfide and N-bromosuccinamide; or dimethylsulfide and chlorine gas; or thioanisole and N-chlorosuccinamide; or thioanisole and N-bromosuccinamide in a suitable organic solvent.

专利号:RU-2162848-C2
优先权日:1996-02-22
标题 :Derivatives of oxa- or thiadizole, methods of their synthesis (variants), pharmaceutical composition